Hepatotoxicity Associated with Cocaine Abuse

  • David H. Van Thiel
  • Joshua A. Perper
Part of the Recent Developments in Alcoholism book series (RDIA, volume 10)


The mechanisms evaluated in animals as being responsible for cocaine associated hepatotoxicity are presented. The importance of the P-450 enzyme system in cocaine associated hepatotoxicity is emphasized. Moreover, the putative critical role of free radicals in such injury is discussed. Finally, the growing literature on clinical cases of cocaine hepatotoxicity is reviewed.


Covalent Binding Cocaine Abuse Cocaine User Benzoyl eCgOnine Acute Cocaine 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • David H. Van Thiel
    • 1
  • Joshua A. Perper
    • 2
  1. 1.Department of SurgeryUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Allegheny County Coroner’s Office, Departments of Pathology and Epidemiology, School of Medicine and School of Public HealthUniversity of PittsburghPittsburghUSA

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