Gastrointestinal Complications of Cocaine Abuse

  • David H. Van Thiel
  • Joshua A. Perper
Part of the Recent Developments in Alcoholism book series (RDIA, volume 10)


The mechanisms thought to be responsible for cocaine-associated gastrointestinal injury are presented. In addition, the literature available concerning the enteric consequences of cocaine use is reviewed.


Ischemic Colitis Intestinal Ischemia Gastrointestinal Complication Cocaine Abuse Gastric Perforation 
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  1. 1.
    Herbei KA: The effects of electrical field stimulation and tetrodotoxin on ion transplant by isolated rabbit ileum. J Clin Invest 62:1039–1047, 1978.CrossRefGoogle Scholar
  2. 2.
    Carey HV Cooke HJ: Tonic activity of submucosal neurons influences on basal ion transport. Life Sci 16:1083–1088, 1989.CrossRefGoogle Scholar
  3. 3.
    Suprenant A, North RA: Mechanisms of synaptic inhibition by noradrenaline acting at 2 adrenoreceptors. Proc R Soc Lond 234:85–114, 1988.CrossRefGoogle Scholar
  4. 4.
    Chang EB, Field M, Miller RJ: Enterocyte α2 adrenergic receptors yohimbine and p-aminoclonidine binding relative to ion transport. Am J Physiol 244:676–682, 1983.Google Scholar
  5. 5.
    Hemlin M, Butcher P, Sjovall H: Electrogenic and electroneutral components of the sympathetic effect on fluid absorption in the rat jejunum. Acta Physiol Scand 131:599–608, 1987.PubMedCrossRefGoogle Scholar
  6. 6.
    McGregor DD: The effect of sympathetic nerve stimulation on vasoconstrictor responses in perfused mesenteric blood vessels of the rat. J Physiol (Lond) 177:21–30, 1965.Google Scholar
  7. 7.
    Collis MG: Vascular reactivity in noradrenaline and angiotensin II in the rat perfused mesenteric vasculature. Cardiovasc Res 9:118–126, 1975.PubMedCrossRefGoogle Scholar
  8. 8.
    Texter EC: Direct effects of vasoactive agents on segmental resistance of mesenteric and portal circulation. J Lab Clin Med 64:624–633, 1964.PubMedGoogle Scholar
  9. 9.
    Abramson DL, Gertler JP, Lewis T, Kral JG: Crack related perforated gastropyloric ulcer. J Clin Gastroenterol 13:17–19, 1991.PubMedCrossRefGoogle Scholar
  10. 10.
    Nalbandian H, Sheth N, Dietrich R, Georgiou J: Intestinal ischemia caused by cocaine injection: report of two cases. Surgery 97:374–376, 1985.PubMedGoogle Scholar
  11. 11.
    Mizrahi S, Laor D, Stamler B: Intestinal ischemia induced by cocaine abuse. Arch Surg 123:394, 1988.PubMedCrossRefGoogle Scholar
  12. 12.
    Cregler LL, Mark H: Medical complications of cocaine abuse. N Engl J Med 315:1495–1500, 1986.PubMedCrossRefGoogle Scholar
  13. 13.
    Fishel R, Hamamato G, Barbel A, Jiji N, Efron A: Cocaine colitis: is this a new syndrome? Dis Colon Rectum 28:264–266, 1985.PubMedCrossRefGoogle Scholar
  14. 14.
    Yang RD, Han MU, McCarthy JH: Ischemic colitis in a crack abuser. Dig Dis Sci 36:238–240, 1991.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • David H. Van Thiel
    • 1
  • Joshua A. Perper
    • 2
  1. 1.Department of SurgeryUniversity of Pittsburgh School of MedicinePittsburghUSA
  2. 2.Allegheny County Coroner’s Office, Departments of Pathology and Epidemiology, School of Medicine and School of Public HealthUniversity of PittsburghPittsburghUSA

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