Microdomains in Polymerizable Diacetylenic Phosphatidylcholine Monolayers
Monolayers of phospholipids may be used as substrates to stabilize membrane proteins on solid supports, in the fabrication of biosensors and other implantable devices. The stability of phospholipid monolayers can be significantly improved by using polymerizable lipids such as photo-polymerizable diacetylenic lipids. These lipids, once polymerized, form extremely stable structures which may be used as surface coating for biocompatible materials, and carrier vehicles for drugs, among other applications.1–3 The fonction and reliability of the surface coating depend to a large extent on the microstructure of the monolayer used. Recent studies have shown that monolayers of lipids on the air-water interface are by no means uniform in structure.4–7 Phase separated domains exist in most monolayers under certain surface pressure. The microscopic domains in monolayer become increasingly important as more microdevices are fabricated. One may even make use of the micro textures in monolayers to delineate spatially separated functional areas on a device surface. To this end, one must understand the physical chemistry of the formation of these microdomains to ascertain the uniformity and stability of the surface coating or deposit.
KeywordsCholesterol Hydrolysis Hydrated Argon Chloroform
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