Transport and Metabolism of Phosphatidylinositol in Eukaryotic Cells

  • George M. HelmkampJr.
Part of the Subcellular Biochemistry book series (SCBI, volume 16)

Abstract

Phospholipids are the major lipid component of eukaryotic cell membranes. A diversity of phospholipid structures is reflected in distributions that are unique to specific intracellular membranes, as well as the cytoplasmic and extracytoplasmic surfaces of the membrane bilayer. Matched to the spectrum of phospholipids within the cell are cytosolic phospholipid transfer proteins. As a general class of catalyst, these proteins facilitate the transport of monomeric phospholipid molecules between membrane domains (Kader et al., 1982; Wirtz, 1982; Helmkamp, 1986). Although a number of interesting and often highly suggestive catalytic activities have been demonstrated in vitro for phospholipid transfer proteins, it has proved frustratingly difficult to define any in vivo function.

Keywords

Cholesterol Estradiol Oligosaccharide Ghost Kelly 

Abbreviations used in this chapter

CerPCho

sphingomyelin

LacCer

lactosylceramide

PC

phosphatidylcholine

PE

phosphatidylethanolamine

PG

phosphatidylglycerol

PGP

phosphatidylglycerol phosphate

PI

phosphatidylinositol

PI4P

phosphatidylinositol 4-phosphate

PI(4,5)P2

phosphatidylinositol 4,5-bisphosphate

PA

phosphatidate

PS

phosphatidylserine

CoA

coenzyme A.

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • George M. HelmkampJr.
    • 1
  1. 1.Department of Biochemistry and Molecular Biology, School of MedicineUniversity of Kansas Medical CenterKansas CityUSA

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