Abstract
Wnt genes are members of a family of vertebrate genes related to the Drosophila gene wingless (wg, Nusse and Warmus, 1992; McMahon, 1992). They encode secreted molecules (Papkoff and Schryver, 1990; Jue et al, 1992) which are thought to be of importance in patterning and growth control during ontogenesis (McMahon and Bradley, 1990; Thomas et al, 1992; Thomas and Capecchi, 1990; Dickinson et al, 1994). Several such genes are transcribed in localised domains during limb budding and morphogenesis (McMahon, 1992; Gavin et al, 1990; Dealy et al, 1993). We report here further observations on a congenital limb malformation in a mouse transgenic line that ectopically expresses Wnt-1 in limb buds (Zakany and Duboule, 1993).
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Zákány, J., Lemaistre, M., Duboule, D. (1995). Ectopic Expression of Wnt-1 Induces Abnormalities in Growth and Skeletal Patterning of the Limbs. In: Zagris, N., Duprat, A.M., Durston, A. (eds) Organization of the Early Vertebrate Embryo. NATO ASI Series, vol 279. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1618-1_25
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DOI: https://doi.org/10.1007/978-1-4899-1618-1_25
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