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Organization of the Early Vertebrate Embryo pp 263–273Cite as

The Pax Family of Transcription Factors in Embryonic Development

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Part of the book series: NATO ASI Series ((NSSA,volume 279))

Abstract

The Pax gene family consists of nine genes identified in the mouse genome by their homology to the Drosophila segmentation gene, paired. The Pax gene products have the biochemical properties of transcription factors and share the conserved paired domain that exhibits DNA binding activity. Pax genes are expressed in temporally and spatially restricted patterns during embryogenesis and control key aspects of embryonic development. Pax gene mutations are semidominantly inherited, and homozygous mouse mutants are usually lethal.

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Author information

Authors and Affiliations

  1. Department of Molecular Cell Biology, Max-Planck institute for Biophysical Chemistry, D-37077, Gottingen, Germany

    Georges Chalepakis & Peter Gruss

Authors
  1. Georges Chalepakis
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  2. Peter Gruss
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Editor information

Editors and Affiliations

  1. University of Patras, Patras, Greece

    Nikolas Zagris

  2. CNRS/Paul Sabatier University, Toulouse, France

    Anne Marie Duprat

  3. Hubrecht Laboratory, Utrecht, The Netherlands

    Antony Durston

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© 1995 Springer Science+Business Media New York

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Chalepakis, G., Gruss, P. (1995). The Pax Family of Transcription Factors in Embryonic Development. In: Zagris, N., Duprat, A.M., Durston, A. (eds) Organization of the Early Vertebrate Embryo. NATO ASI Series, vol 279. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1618-1_21

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  • DOI: https://doi.org/10.1007/978-1-4899-1618-1_21

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1620-4

  • Online ISBN: 978-1-4899-1618-1

  • eBook Packages: Springer Book Archive

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