Is Collagen Remodeling Associated with Bladder Obstruction?

  • H. Paul Ehrlich
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 385)

Abstract

Collagen, proteoglycans and elastin combined with resident smooth muscle cells (SMC) makeup the basic structural unit of the bladder wall. Any pathologic process that alters either the content or organization of collagen within the bladder wall will modulate the ability of the bladder to store urine or efficiently empty itself (1). An obstruction that develops at the outlet of the bladder results from a narrowing of that lumen. There are numerous physiological and anatomical possibilities for producing the constricture of that lumen. In some constrictures it is proposed that connective tissue remodeling is critical in causing the narrowing of the lumenal space in the bladder outlet.

Keywords

Ischemia Rubber Luminal Compaction Fibril 

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References

  1. 1.
    Zderic SA, Wein AJ, Monson FC, Levin RM (1991) The effects of intravesical obstruction on the bladder. Problem Urol 5:357–368.Google Scholar
  2. 2.
    Uvelius B, Persson L, Mattiasson A (1984) Smooth muscle cell hypertrophy and hyperplasia in the rat detractor after short-term intravesical outflow obstruction. J Urol 131:173.PubMedGoogle Scholar
  3. 3.
    Mayo ME, Hinnam Jr F (1976) Structure and function of rabbit bladder altered by chronic obstruction or cystitis. Invest. Urol 14:6.PubMedGoogle Scholar
  4. 4.
    Brody GS, Peng TJ, Landel RF (1984) The etiology of hypertrophic scar: Another view. Plast Reconst. Surg 67:673–684.Google Scholar
  5. 5.
    Gabbiani G, Hirschel BJ, Ryan GB, Statkov PR, and Majno G (1972) Granulation tissue as a contractile organ: A study of structure and function. J Exp Med 135:719–734.PubMedCrossRefGoogle Scholar
  6. 6.
    Hirsch BJ, Gabbiani G, Ryan GB, Majno G (1971) Fibroblasts of grannulation tissue: Immunofluorescent staining with anti-smooth muscle serum. Proc Soc Exp Biol. Med 138:466–469.CrossRefGoogle Scholar
  7. 7.
    Baur PS, Larson DL, Stacey TR (1975) The observation of myofibroblasts in hypertrophic scars. Surg Gynecol Obstet 141:22–26.PubMedGoogle Scholar
  8. 8.
    Darby I, Skalli O, Gabbiani G (1990) alpha smooth muscle actin is trasiently expressed by myofibroblasts during experimental wound healing. Lab Invest. 63:21–29.PubMedGoogle Scholar
  9. 9.
    Gabbiani G, Maino G (1972) Dupuytrens contracture: Fibroblast contraction? Am J Pathol. 66:131–138.PubMedGoogle Scholar
  10. 10.
    Rungger-Brondle E, Gabbiani G (1983) The role of cytoskeleton and cytocontractile elements in pathologial processes. Am J Pathol. 110:359–392.Google Scholar
  11. 11.
    Eddy RJ, Petro JA, Tomasek JJ (1988) Evidence for the nonmuscle nature of the “myofibroblast” of granulation tissue and hypertrophic scar. An immunofluorescence study. Am J Pathol. 130:252–260.Google Scholar
  12. 12.
    Maino G, Gabbiani G, Hirschel BJ, Ryan GB (1971) Contraction of granulation tissue in vitro: Similarity to smooth muscle. Science 173:548–550.CrossRefGoogle Scholar
  13. 13.
    Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G (1993) Transforming growth factor-1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol. 122:103–111.PubMedCrossRefGoogle Scholar
  14. 14.
    Tomasele, JJ, Haaksma, CJ, Eddy, RJ, Vaughan, MB (1992) Fibroblasts contraction occurs on release of tension in attached collagen lattices: Dependency on an organized actin cytoskeleton and serum. Anat. Rec. 232:359–368.CrossRefGoogle Scholar
  15. 15.
    Harris AK, Wild P, Stopak D (1980) Silicone rubber substrate: A new wrinkle in the study of cell locomotion. Science 280:177–179.CrossRefGoogle Scholar
  16. 16.
    Harris AK, Stopak D, Wild P (1981) Fibroblast traction as a mechanism for collagen morphogenesis. Nature 290: 249–251.PubMedCrossRefGoogle Scholar
  17. 17.
    Bailey AJ, Bazin S, Sims TJ, LeLous M., Nicoletis C., DeLaunay A (1975) Characterization of the collagen of human hypertrophic and normal scars. Biochem Acta 405:412–421.CrossRefGoogle Scholar
  18. 18.
    Bailey AJ, Sims TJ, LeLous M., Bazin A (1975) Collagen polymorphism in experimental granulation tissue. Biochem Biophys Res Comm 66:1160–1165.PubMedCrossRefGoogle Scholar
  19. 19.
    Ehrlich HP, White BS (1979) Zone precipitation chromatography: Its use in the isolation of different collagen types. Prep Biochem 9:407–425.PubMedCrossRefGoogle Scholar
  20. 20.
    Bell E, Ivarsson B, Merrill C, (1979) Production of a tissue-like structure by contraction of collagen lattices by human fibroblasts of different proliferation potential in vitro. Proc Natl. Acad Sci (USA) 76:1274–1278.CrossRefGoogle Scholar
  21. 21.
    Ehrlich HP (1988) Wound closure: Evidence of cooperation between fibroblasts and collagen matrix in scar contracture. Eye 2:149–157.PubMedCrossRefGoogle Scholar
  22. 22.
    Ehrlich HP, Buttle DJ, Bernanke DH (1989) Physiological variables affecting collagen lattice contraction by humen dermal fibroblasts. Exp Mole Path 50:220–229.CrossRefGoogle Scholar
  23. 23.
    Ehrlich HP, Griswold TR (1984) EBdr fibroblasts produce increased concentrations of cAMP within a collagen matrix. J Invest. Derm. 83:220–233.CrossRefGoogle Scholar
  24. 24.
    Ehrlich HP, Rockwell WB, Cornwell, TL, Rajaratnan, JBM (1991) A role for myosin light chain kinase in FPCL contraction. J Cell Physol 146:1–7.CrossRefGoogle Scholar
  25. 25.
    Ehrlich, HP, Griswold, BS, Rajaratnam, JBN. (1986) ATP-induced cell contraction with EBdr and normal dermal fibroblasts. J. Invest. Derm. 86:96–100.PubMedCrossRefGoogle Scholar
  26. 26.
    Horowitz, AF, Hatten, ME, Burger, MM (1974) Membrane fatty acid replacement and their effect on growth and lectin-induced agglutinability. Proc. Nat. Acad. Sci. USA 71:3115–3119.CrossRefGoogle Scholar
  27. 27.
    Rittenberg T, Ehrlich HP (1992) Free fatty acids and dialyzed serum alterations of FPCL contraction. Tiss Cell 24:243–251.CrossRefGoogle Scholar
  28. 28.
    Ehrlich HP, Rajaratnam JBJN (1990) Cell locomotion forces versus cell contraction forces for collagen lattice contraction: An in vitro model of wound contraction. Tiss Cell 22:407–417.CrossRefGoogle Scholar
  29. 29.
    Ehrlich HP (1988) The role of connective tissue matrix in wound healing. Prog Clin Biol Res 266:243–258.PubMedGoogle Scholar
  30. 30.
    Ehrlich HP (1988) The modulation of contraction of FPCL by types I, II, and III collagen. Tiss. Cell 20:47–50.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • H. Paul Ehrlich
    • 1
  1. 1.Division of Pediatric Surgery, Department of Surgery, Milton S. Hershey Medical CenterPennsylvania State College of MedicineHersheyUSA

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