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3D Structure at 2.7 Å Resolution of Native and E202Q Mutant Human Acetylcholinesterase Complexed with Fasciculin-II

  • Gitay Kryger
  • Kurt Giles
  • Michal Harel
  • Lilly Toker
  • Baruch Velan
  • Ariel Lazar
  • Chanoch Kronman
  • Dov Barak
  • Naomi Ariel
  • Avigdor Shafferman
  • Israel Silman
  • Joel L. Sussman

Abstract

Knowledge of the 3D structure of human acetylcholinesterase (AChE) is of importance for drug design, in particular of anti-Alzheimer drugs (1, 2), for development of improved procedures for treatment of intoxication by nerve agents (3), and for the design of safer and more effective insecticides.

Keywords

E202Q Mutant Catalytic Triad Residue Active Site Gorge Sugar Side Chain Green Mamba 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Gitay Kryger
    • 1
  • Kurt Giles
    • 1
    • 2
  • Michal Harel
    • 1
  • Lilly Toker
    • 2
  • Baruch Velan
    • 3
  • Ariel Lazar
    • 3
  • Chanoch Kronman
    • 3
  • Dov Barak
    • 3
  • Naomi Ariel
    • 3
  • Avigdor Shafferman
    • 3
  • Israel Silman
    • 2
  • Joel L. Sussman
    • 1
    • 4
  1. 1.Department of Structural BiologyWeizmann Institute of ScienceRehovotIsrael
  2. 2.Department of NeurobiologyWeizmann Institute of ScienceRehovotIsrael
  3. 3.Israel Institute for Biological ResearchNess ZionaIsrael
  4. 4.Biology DepartmentBrookhaven National LaboratoryUptonUSA

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