The Glycolipid-Addition Signal of Acetylcholinesterase

Cellular Compartmentation, Cleavage, GPI Addition and Secretion
  • Suzanne Bon
  • Françoise Coussen
  • Jean Massoulié

Abstract

Various types of acetylcholinesterase (AChE) subunits are characterized by specific C-terminal peptides. In Torpedo and mammals, alternative exons encode H peptides, which contain a C-terminal signal for glypiation, i. e. cleavage and addition of a glycolipid (GPI) anchor. The H peptides of Torpedo and rat AChE show no homology, except for the presence of cysteines at their N-terminal end, allowing the formation of disulfide-linked dimers, and of a C-terminal hydrophobic region.

Keywords

Cysteine Dium Cholinesterase Acetylcholinesterase 

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Suzanne Bon
    • 1
  • Françoise Coussen
    • 1
  • Jean Massoulié
    • 1
  1. 1.Neurobiologie Cellulaire et MoléculaireCNRS URA 1857, Ecole Normale SupérieureParisFrance

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