The Coronavirus Membrane Glycoprotein
Coronaviruses have a simple protein composition. While there is some variation among different members, a basic set of four protein species universally occurs: the nucleocapsid protein (N), the spike protein (S), a small membrane protein (SM), and the membrane glycoprotein (M). Some coronaviruses have an additional membrane glycoprotein (HE). The M protein, previously also called El, is the subject of this chapter. As will become clear, M is a peculiar glycoprotein, different from all other viral glycoproteins in its structural and biochemical features. These unique features may be responsible for important biological properties of coronaviruses, in particular for their intracellular budding.
KeywordsCarbohydrate Serine Lysine Oligomerization Diarrhea
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