Neuroactive Amino Acids in Synaptosomes from Focal and Nonfocal Temporal Lobe Tissue of Patients with Intractable Complex Partial Seizures

  • P.-L. Lleu
  • D. Labiner
  • M. Weinand
  • R. J. Huxtable
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 359)

Abstract

The putative involvement of disturbances in amino acid patterns in the pathogenesis of epilepsy has been vigorously debated (13,34,36,47,50). Amino acid levels in whole tissue removed from epileptic foci at surgery or autopsy have been compared with levels in surrounding nonfocal tissue or with tissue removed at autopsy or surgery from nonepileptic subjects. The advantages and disadvantages of each procedure have been argued at length (13,34,36,47,50). No clear pattern of changes has emerged, however (2,5,7,10,12,13,15,1–8,19,21,23,26,30,32,35,36,38,40,48,50). The literature on changes in amino acids in epilepsy has been reviewed (9,16).

Keywords

Cobalt Glycine Cysteine Sulfuric Acid Glutamine 

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • P.-L. Lleu
    • 1
  • D. Labiner
    • 1
  • M. Weinand
    • 1
  • R. J. Huxtable
    • 1
  1. 1.College of MedicineUniversity of Arizona Health Sciences CenterTucsonUSA

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