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Toxicology of Dioxins and Related Chemicals

  • Chapter
Dioxins and Health

Abstract

Chlorinated dibenzo-p-dioxins are environmental contaminants present in a variety of environmental media. This class of compounds has caused great concern in the general public as well as generated intense interest in the scientific community. The public concerns stem from the characterization of dioxin as one of the most potent “man-made” toxicants ever studied. Indeed, these compounds are extremely potent at producing a variety of toxic effects in experimental animals. The most potent of these chemicals is 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD). 2,3,7,8-TCDD and its congeners produce a wide spectrum of toxic effects including immunotoxicity, teratogenicity, carcinogenicity, and lethality. The interest in dioxins and its congeners in the scientific community arises because many of their toxic effects are associated with alterations in growth and development of a variety of different cell types present in different organs. Thus, dioxins can be used as tools to study mechanisms of growth and development. Recent laboratory studies have provided new insights into the mechanisms involved in the toxicity of dioxins. These findings, in conjunction with epidemiology studies, indicate that at least some portions of the population are exposed to concentrations of dioxins and related compounds which may be causing subtle effects.

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Authors and Affiliations

  1. Center for Environmental Medicine and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27514, USA

    Michael J. DeVito

  2. Environmental Toxicology Division, Health Effects Research Laboratory, United States Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, USA

    Linda S. Birnbaum

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  1. Michael J. DeVito
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  1. Department of Preventive Medicine, University of New York Health Science Center-Syracuse, Binghamton, New York, 13903, USA

    Arnold Schecter

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DeVito, M.J., Birnbaum, L.S. (1994). Toxicology of Dioxins and Related Chemicals. In: Schecter, A. (eds) Dioxins and Health. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1462-0_5

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