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Development of Vaccines by Grafting Microbial Epitopes in Immunoglobulins

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Modern Vaccinology

Abstract

The variable regions (V) of immunoglobulin (Ig) bear antigenic determinants that can stimulate both B and T lymphocytes. There is solid evidence that such antigenic determinants and particularly the idiotypes, which are phenotypic marker of V genes stimulate the expansion of B cells producing anti-Id antibodies in xenogeneic (Kunkel et al., 1963), allogenic (Oudin and Michel, 1963) and autologous (Rodkey, 1974) systems as well as idiotype specific T cells (Eichman and Rajewsky, 1975; Bona et al., 1979). The expression of idiotypes usually correlates with aminoacid sequences within CDR loops of V regions of Ig molecules (Capra et al., 1977; Rudikoff et al., 1983).

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Authors and Affiliations

  1. Department of Microbiology, Mount Sinai School of Medicine, New York, NY, USA

    Constantin A. Bona

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  1. Constantin A. Bona
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Editors and Affiliations

  1. University of Montreal, Montreal, Quebec, Canada

    Edouard Kurstak

  2. World Health Organization, Geneva, Switzerland

    Edouard Kurstak

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Bona, C.A. (1994). Development of Vaccines by Grafting Microbial Epitopes in Immunoglobulins. In: Kurstak, E. (eds) Modern Vaccinology. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1450-7_3

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  • DOI: https://doi.org/10.1007/978-1-4899-1450-7_3

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