Callosal and Thalamic Transection: Effects on Spontaneous and Pentylenetetrazol-Induced Absence Seizures in Rats
In a strain of Wistar rats inbred in our laboratory, all animals are affected with generalized nonconvulsive epilepsy (absence or petit mal epilepsy). The seizures occur when animals are awake and inactive, with a frequency of about one per minute, and they disappear during activity and sleep. The behavioral characteristics during the seizures are immobility, reduced tone in neck muscles and usually rhythmic vibrissal twitches. In contrast with these discrete clinical signs, drastic EEG manifestations characterize the seizures: large 7–9 c/s spike and wave discharges (SWD), the duration of which may exceed one minute, with a mean duration of 20 s/min. in our recording conditions.
KeywordsDepression Penicillin NeuroL Sponge Paraffin
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