HIV—Peplotion Vaccine

A Novel Approach to Vaccination against AIDS by Transepithelial Transport of Viral Peptides and Antigens to Langerhans Cells for Induction of Cytolytic T Cells by HLA Class I and CD1 Molecules for Long Term Protection
  • Yechiel Becker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 397)


Two properties of the human immunodeficiency virus (HIV) make the control of HIV spread in the human population difficult: a) infection of T cells and dendritic cells and macrophages, the professional antigen-presenting cells and b) transmission from donor to recipient by HIV-1 -infected cells. The rapid spread of HIV infection in the human population in epidemic form was enhanced by the transmission of infected cells from infected individuals to non-infected partners as part of human sexual behavior, and due to exposure of intravenous drug users to infected syringes. Despite attempts to educate the human population in safe sexual behavior, the spread of HIV infection continues and the end of the HIV epidemic is not in sight.


Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Viral Peptide Human Immunodeficiency Virus Protein Lipid Antigen 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Yechiel Becker
    • 1
  1. 1.Department of Molecular Virology, Institute of Microbiology, Faculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael

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