Advertisement

HIV—Peplotion Vaccine

A Novel Approach to Vaccination against AIDS by Transepithelial Transport of Viral Peptides and Antigens to Langerhans Cells for Induction of Cytolytic T Cells by HLA Class I and CD1 Molecules for Long Term Protection
  • Yechiel Becker
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 397)

Abstract

Two properties of the human immunodeficiency virus (HIV) make the control of HIV spread in the human population difficult: a) infection of T cells and dendritic cells and macrophages, the professional antigen-presenting cells and b) transmission from donor to recipient by HIV-1 -infected cells. The rapid spread of HIV infection in the human population in epidemic form was enhanced by the transmission of infected cells from infected individuals to non-infected partners as part of human sexual behavior, and due to exposure of intravenous drug users to infected syringes. Despite attempts to educate the human population in safe sexual behavior, the spread of HIV infection continues and the end of the HIV epidemic is not in sight.

Keywords

Human Immunodeficiency Virus Human Immunodeficiency Virus Infection Viral Peptide Human Immunodeficiency Virus Protein Lipid Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Becker, Y., 1993, From the discovery of poliovirus vaccinia virus mRNAs and polyribosomes to computer analysis of HIV-1 and 2 glycoproteins, in Concepts in Virology (B.W.J. Mahy and D.K. Lvov, editors) pp 77-79, Hardwood Academic Publishers.Google Scholar
  2. Becker, Y, 1994a, HIV-1 proteins in infected cells determine the presentation of viral peptides by HLA class I and class II molecules and the nature of the cellular and humoral antiviral immune responses-a review, Virus Genes, 8:249–270.PubMedCrossRefGoogle Scholar
  3. Becker, Y, 1994b, An analysis of the role of skin Langerhans cells (LC) in the cytoplasmic processing of HIV-1 peptide after “peplotion” transpidermal transfer and HLA class I presentation to CD8+ CTLs-an approach to immunization of humans, Virus Genes, 9:133–147.CrossRefGoogle Scholar
  4. Becker, Y, 1995, Computer simulations to predict the availability of peptides with known HLA class I motifs possibly generated by proteolysis of HIV-1 proteins in infected cells, Virus Genes 10:in press.Google Scholar
  5. Beckman, E.M., Porcelli, S.A., Morita, CT., Behar, S.M., Furlong, S., and Brenner, M.B., 1994, Recognition of a lipid antigen by CD1 restricted α/β+ T cells, Nature, 37: 691–694.CrossRefGoogle Scholar
  6. Bjorkman, P.J., Saper, M.A., Samaraoni, B., Bennet, W.S., Strominger, J.L., and Wiley, D.C., 1987, The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens. Nature 329:512–518, 1987.PubMedCrossRefGoogle Scholar
  7. Bolognesi, D., 1994, Not Yet, it is too early to use a live attenuated virus vaccine against HIV-1, J. NIH Res. 6:55,59-62.Google Scholar
  8. Cameron, P.U., Mallal, S.A., French, M.A.H., and Dawkins, R.L. 1990, Central MHC genes between HLA-B and complement C4 confer risk for HIV-1 disease progression, Human Immunology 29:282–295.PubMedCrossRefGoogle Scholar
  9. Choi, H.K., Flynn, G.L., and Amidon, G.G., 1994, Transdermal delivery of bioactive peptides: the effect of n-decylmethyl solfoxide, pH and inhibitors of enkephalin metabolism and transport, Pharm. Res. 7:1099–1106, 1990.CrossRefGoogle Scholar
  10. Desrosiers, R.C., 1994, Yes, it is time to consider use of a live-attenuated virus vaccine against HIV, J. NIH Res. 6:54,56-59.Google Scholar
  11. Haynes, B.F., 1993, Scientific and social issues of human immunodeficiency virus vaccine development, Science 260:1279–1286.PubMedCrossRefGoogle Scholar
  12. McKinney, E.L., and Streilein, J.W., 1989, On the extraordinary capacity of allogeneic epidermal Langerhans cells to prime cytotoxic T cells in vivo, J. Immunol. 143:1560–1564.PubMedGoogle Scholar
  13. Nair, S., Babu, J.S., Dunham, R.G., Kanda, P., Burke, R.L., and Rouse, B.T., 1993, Induction of primary, antiviral cytotoxic, and proliferative responses with antigens administered via dendritic cells, J. Virol. 67:4062–4069.PubMedGoogle Scholar
  14. Porcelli, S., Brenner, M.B., Greenstein, J.L., Balk, S.P., Terhorst, C. and Bleicher, P.A., 1989, Recognition of cluster of differentiation 1 antigens by human CD4CD8 cytolytic T lymphocytes, Nature 341:447–450.PubMedCrossRefGoogle Scholar
  15. Porcelli, S., Morita, C.T., and Brenner, M.B., 1992, CD1b restricts the response of human CD48 T lymphocytes to a microbial antigen, Nature 360:593–597.PubMedCrossRefGoogle Scholar
  16. Rabinovich, N.R., Mclnnes, P., Klein, D.L., and Hall, B.F., 1994, Vaccine technologies: view to the future, Science 265:1401–1404.PubMedCrossRefGoogle Scholar
  17. Reid, C.D.L., Fryer, PR., Clifford, C., Kirk, A., Tikerpae, J., and Knight, S.C., 1990, Identification of hematopoietic progenitors of macrophages and dendritic Langerhans cells (DL-CFU) in human bone marrow and peripheral blood, Blood 76:1139–1149.PubMedGoogle Scholar
  18. Sabin, A.B., 1992, Improbability of effective vaccination agaoinst human immunodeficiency virus because of its intracellular transmission and rectal portal of entry, Proc. Natl. Acad. Sci. USA 89:8852–8855.PubMedCrossRefGoogle Scholar
  19. Salk, J., Bretscher, P.A., Salk, PL., Clerici, M., and Shearer, G.M., 1993, A strategy for prophylactic vaccination against AIDS, Science 260:1270–1272.PubMedCrossRefGoogle Scholar
  20. Schultz, M., Zinkernagel, R.M., and Hengartner, H., 1991, Peptide-induced antiviral protection by cytotoxic T cells, Proc. Natl. Acad. Sci. USA 88:991–993.CrossRefGoogle Scholar
  21. Takahashi, H., Takeshita, T., Morein, B., Putney, S., Germain, R.N., and Berzofsky, J.A., 1990, Induction of CD8+ cytotoxic T cells by imunization with purified HIV-1 envelope protein in ISCOMs, Nature 34:873–875.CrossRefGoogle Scholar
  22. Walker, C., Selby, M., Erickson, A., Do, D.C., Valensi, J-P, and Van Nest, G., 1992, Cationic lipids direct a viral glycoprotein into class I major histocompatibility complex antigen-presentation pathway, Proc. Natl. Acad. Sci. USA 89:7915–7918.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Yechiel Becker
    • 1
  1. 1.Department of Molecular Virology, Institute of Microbiology, Faculty of MedicineThe Hebrew University of JerusalemJerusalemIsrael

Personalised recommendations