Two properties of the human immunodeficiency virus (HIV) make the control of HIV spread in the human population difficult: a) infection of T cells and dendritic cells and macrophages, the professional antigen-presenting cells and b) transmission from donor to recipient by HIV-1 -infected cells. The rapid spread of HIV infection in the human population in epidemic form was enhanced by the transmission of infected cells from infected individuals to non-infected partners as part of human sexual behavior, and due to exposure of intravenous drug users to infected syringes. Despite attempts to educate the human population in safe sexual behavior, the spread of HIV infection continues and the end of the HIV epidemic is not in sight.
KeywordsHuman Immunodeficiency Virus Human Immunodeficiency Virus Infection Viral Peptide Human Immunodeficiency Virus Protein Lipid Antigen
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- Becker, Y., 1993, From the discovery of poliovirus vaccinia virus mRNAs and polyribosomes to computer analysis of HIV-1 and 2 glycoproteins, in Concepts in Virology (B.W.J. Mahy and D.K. Lvov, editors) pp 77-79, Hardwood Academic Publishers.Google Scholar
- Becker, Y, 1995, Computer simulations to predict the availability of peptides with known HLA class I motifs possibly generated by proteolysis of HIV-1 proteins in infected cells, Virus Genes 10:in press.Google Scholar
- Bolognesi, D., 1994, Not Yet, it is too early to use a live attenuated virus vaccine against HIV-1, J. NIH Res. 6:55,59-62.Google Scholar
- Desrosiers, R.C., 1994, Yes, it is time to consider use of a live-attenuated virus vaccine against HIV, J. NIH Res. 6:54,56-59.Google Scholar