Chemistry and Biological Activity of AAL Toxins

  • Carl K. Winter
  • David G. Gilchrist
  • Martin B. Dickman
  • Clinton Jones
Part of the Advances in Experimental medicine and Biology book series (AEMB, volume 392)


AAL toxins and fumonisins comprise a family of highly reactive, chemically related mycotoxins that disrupt cellular homeostasis in both plant and animal tissues. Two critical issues to resolve are the detection of the entire family in food matricies and the mode of cellular disruption. Analysis of the entire set of chemical congeners in food matrices is difficult but has been achieved by a combination of different HPLC and mass spectrometry strategies. The mode of cellular disruption is unknown but likely involves changes associated with the inhibition of ceramide synthase in both plants and animals. Toxin treated cells exhibit morphological and biochemical changes characteristic of apoptosis. Further evaluation of the specific genetic and biochemical changes that occur during toxin-induced cell death may aid in understanding the mole of the action of these mycotoxins.


High Performance Liquid Chromatography Alternaria Alternata Sphingoid Base Fusarium Moniliforme Tetrahedron Letter 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Carl K. Winter
    • 1
  • David G. Gilchrist
    • 2
  • Martin B. Dickman
    • 3
  • Clinton Jones
    • 4
  1. 1.Department of Food Science and TechnologyUniversity of California, DavisDavisUSA
  2. 2.CEPRAP and Department of Plant PathologyUniversity of California, DavisDavisUSA
  3. 3.Department of Plant PathologyUniversity of Nebraska, LincolnLincolnUSA
  4. 4.Department of Veterinary and Biomedical Science and The Center for BiotechnologyUniversity of Nebraska, LincolnLincolnUSA

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