AT1-Receptors and Cellular Actions of Angiotensin II in Neuronal Cultures of Stroke Prone-Spontaneously Hypertensive Rat Brain

  • Mohan K. Raizada
  • Di Lu
  • Hong Yang
  • Kan Yu
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 396)


AT1 preceptors, its mRNA and cellular actions of angiotensin II (Ang II) have been compared between neuronal cultures of Wistar Kyoto (WKY) and stroke-prone spontaneously hypertensive (SP-SH) rat brains. Bmax for AT1-receptor binding is 2-fold higher and is associated with a parallel increase in the levels of AT1 preceptor mRNA in SP-SH rat brain neurons compared with WKY rat brain neurons. Ang II causes stimulation of both c-fos and norepinephrine transporter (NET) mRNAs in both strains of neurons and this stimulation is also 2–3-fold higher in SP-SH rat brain neurons compared with WKY rat brain neurons. In contrast, Ang II stimulation of PAI-1 mRNA in SP-SH neurons is only 50% that of in WKY rat brain neurons suggesting that SP-SH neurons express a decrease in AT1-receptor coupling with PAI-1 response. These observations demonstrate that SP-SH neurons express AT1-receptor-functions similar to those described for SHR neurons.


Losartan Potassium Receptor Gene Expression Spontaneously Hypertensive Sustained Antihypertensive Effect Ofplasminogen Activator 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Mohan K. Raizada
    • 1
  • Di Lu
    • 1
  • Hong Yang
    • 1
  • Kan Yu
    • 1
  1. 1.Department of PhysiologyUniversity of FloridaGainesvilleUSA

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