Atypical (Non-AT1, Non-AT2) Angiotensin Receptors

  • Roger D. Smith
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 396)


Angiotensin II (Ang II), the principal active component of the renin-angiotensin system (RAS), plays a major role in the physiology of the cardiovascular system by affecting diverse target tissues such as vascular smooth muscle (to stimulate vasoconstriction), myocardium (to increase heart rate and contractile force), adrenal cortex (to release aldosterone) and medulla (to release catecholamines), pituitary (to regulate release of Vasopressin and other hormones), kidney (to promote sodium reabsorption) and brain (to increase thirst and drinking, and to stimulate a centrally-mediated pressor response) (reviewed in 1–3). The peptide also promotes cardiac hypertrophy and contributes to the neointimal proliferation of vascular smooth muscle following arterial injury (4,5). The potential role of Ang II as a growth factor also implicates it in the pathogenesis of hypertension and atherosclerosis (6). In addition to these effects on the cardiovascular system, Ang II may also be active in non-cardiovascular tissues such as the ovary (7,8).


Amino Acid Sequence Homology Moderate Affinity Phosphoinositide Hydrolysis Inositol Phosphate Production Principal Active Component 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Roger D. Smith
    • 1
  1. 1.Department of Clinical BiochemistryAddenbrooke’s HospitalCambridgeUK

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