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Identification of AT1 Receptors on Cultured Astrocytes

  • E. Ann Tallant
  • Debra I. Diz
  • Carlos M. Ferrario
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 396)

Abstract

It is well established that the brain contains an endogenous renin-angiotensin system (RAS) that participates in the regulation of blood pressure through the control of water intake and sodium appetite, the secretion of ACTH and Vasopressin and the regulation of sympathetic tone (1). While high affinity binding sites for Ang II were initially characterized in brain homogenates (2, 3), the technique of in vitro receptor autoradiography allowed visualization of Ang II binding sites to specific brain regions including the circumventricular organs, hypothalamus, dorsal and ventral medulla, spinal cord and pituitary gland (1, 4, 5). These brain regions correspond to areas at which the peptide exerts its physiological effects (5) or where the responses are inhibited by Ang II receptor antagonists (6).

Keywords

Inositol Phosphate Scatchard Plot Human Astrocyte Losartan Potassium High Affinity Binding Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • E. Ann Tallant
    • 1
  • Debra I. Diz
    • 1
  • Carlos M. Ferrario
    • 1
  1. 1.Hypertension CenterBowman Gray School of MedicineWinston-SalemUSA

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