A Novel Second Messenger and Lipid Mediator
  • Yusuf A. Hannun
  • Lina M. Obeid
  • Ghassan S. Dbaibo
Part of the Handbook of Lipid Research book series (HLRE, volume 8)


Phospholipids have long been known to be integral structural components of cell membranes. Their ability to spontaneously form a lipid bilayer which provides a permeability barrier between extracellular and intracellular compartments is essential for cell survival. Over the last several decades, another role became widely appreciated. Phospholipids, particularly glycerolipids, emerged as a rich reservoir of a broad variety of bioactive molecules generated in response to extracellular stimuli (Dennis et al., 1991; Liscovitch and Cantley, 1994). These metabolites can function either as intracellular second messengers [such as diacylglycerol (DAG), inositol triphosphate, and arachidonic acid] or as intercellular mediators (such as platelet-activating factor and the eicosanoids) (Nishizuka, 1992; Rhee et al., 1989; Majerus et al., 1986; Berridge and Irvine, 1989; Nahorski and Potter, 1989; Hanahan, 1986; Exton, 1990). A number of signaling pathways have now been well established with increasingly complex cross-interactions. The common theme is that of an extracellular signal-activated phospholipase that has specificity to a particular phospholipid substrate present in the cell membrane. The subsequent hydrolysis of the phospholipid results in the generation of bioactive molecules that are either released extracellularly where they exert their functions by binding to specific receptors on target cells or diffuse intracellularly where they act on specific targets (e.g., the different protein kinase C isozymes or calcium channels) (Nishizuka, 1992; Rhee et al., 1989). These pathways are discussed in detail elsewhere in this volume.


Nerve Growth Factor Okadaic Acid Senescent Cell Human Diploid Fibroblast Ceramide Level 
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Copyright information

© Springer Science+Business Media New York 1996

Authors and Affiliations

  • Yusuf A. Hannun
    • 1
  • Lina M. Obeid
    • 1
  • Ghassan S. Dbaibo
    • 2
  1. 1.Department of Medicine and Cell BiologyDuke University Medical CenterDurhamUSA
  2. 2.Department of PediatricsDuke University Medical CenterDurhamUSA

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