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The Biology of Tumors pp 127–143Cite as

Deregulation of Cyclin D1 in Cancer

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Part of the book series: Pezcoller Foundation Symposia ((PFSO,volume 9))

Abstract

Cell cycle progression in eukaryotic cells is governed by a series of cyclins and cyclin dependent kinases. Individual cyclins act at different phases of the cell cycle by binding and stimulating the activities of cdk’s. Because these cyclins and cdk’s are pivotal to cell cycle control and thereby cell proliferation, mutational changes and alterations in expression of the corresponding genes play a critical role in transformation and tumor progression (for reviews, see Sherr, 1996; Hunter, 1997). In epithelial cells most of these alterations affect the requirement of cells to respond to external growth factors and to adhere onto extracellular matrix components for proliferation, and involve the regulatory circuits controlling the transitions of the G1 and S phase of the cell cycle.

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References

  • Altucci, L, Addeo, R, Cicatiello, L, Dauvois, S, Parker, MG, Truss, M, Beato, M, Sica, V, Bresciani, F and Weisz, A. (1996). 17B-Estradiol induces cyclin D1 gene transcription, p36Dl-p34cdk4 complex activation and. p105 Rb phosphorylation during mitogenic stimulation of G1-arrested human breast cancer cells. Oncogene 12, 2315–2324.

    CAS  PubMed  Google Scholar 

  • Aronica, SM, Kraus, WL and Katzenellenbogen, BS. (1994). Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci USA 91, 8517–8521.

    Article  CAS  PubMed  Google Scholar 

  • Assoian, RK. (1997) Anchorage-dependent cell cycle progression. J Cell Biol 136, 1, 1–4.

    Article  CAS  PubMed  Google Scholar 

  • Baldin, V, Lukas, J, Mrcote, M-J, Pagano, M, Draetta, G. (1993). Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes & Developm 7, 812–821.

    Article  CAS  Google Scholar 

  • Barbareschi, M, Pelosio, P, Caffo, O, Buttita, F, Pellegrini, S, Barbazza, R, Palma, PD, Bevilacqua, G, Marcetti, A. (1997). Cyclin-D1 gene amplification and expression in breast carcinoma: relation with clinicopathologic characteristics and with retinoblastoma gene product, p53 and p21 WAF1 immunohistochemical expression. Int J Cancer (Pred Oncol) 74, 171–174.

    Article  CAS  Google Scholar 

  • Bartek, J, Bartkova, J and Lukas, J. (1996). The retinoblastoma protein pathway and the restriction point. Curr Opin in Cell Biol 8, 805–814.

    Article  CAS  Google Scholar 

  • Bates, S, Parry, D, Bonetta, L, Vousden, K, Dickson, C and Peters, G. (1994). Absence of cyclin D/cdk complexes in cells lacking functional retinoblastoma protein. Oncogene 9, 1633–1640.

    CAS  PubMed  Google Scholar 

  • Bates, S, and Peters, G. (1995). Cyclin D1 as a cellular proto-oncogene. Cancer Biol, 6, 73–82.

    Article  CAS  Google Scholar 

  • Bellacosa, A, Almadori, G, Cavallo, S, Cadoni, G, Galli, J, Ferrandina, G, Scambia, G, Neri, G. (1996). Cyclin D1 gene amplification in human laryngeal squamous cell carcinomas: prognostic significance and clinical implications. Clin Cancer Res 2, 175–180.

    CAS  PubMed  Google Scholar 

  • Berry, M, Metzger, D, and Chambon, P (1990). Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J. 9, 2811–2818.

    CAS  PubMed  Google Scholar 

  • Boer de, CJ, Loyson, S, Kluin, PM, Kluin-Nelemans, HC, Schuuring, E, Krieken van, JHJM. (1993). Multiple breakpoints within the BCL-1 locus in B cell lymphoma: rearrangements of the cyclin D1 gene. Cancer Res 53, 4148–4152.

    PubMed  Google Scholar 

  • Bonapace, IM, Addeo, R, Altucci, L, Cicatiello, L, Bifulco, M, Laezza, C, Salzano, S, Sica, V, Bresciani, F, and Weisz, A. (1996). 17β-Estradiol overcomes a G1 block induced by HMG-CoA reductase inhibitors and fosters cell cycle progression without inducing ERK-1 and-2 MAP kinase activation. Oncogene 12, 753–763.

    CAS  PubMed  Google Scholar 

  • Bunone, G, Briand, PA, Miksicek, RJ, Picard, D. (1996). Activation of the unliganded estrogen receptor by EGF involves the MAP kinase pathway and direct phosphorylation. EMBO J. 15, 9, 2174–2183.

    CAS  PubMed  Google Scholar 

  • Catzavelos, C, Bhattacharya, N, Ung, YC, Wilson, JA, Roncari, L, Sandhu, C, et al., (1997). Decreased levels of cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer. Nature (Medicine) 3, 227–230.

    Article  CAS  Google Scholar 

  • Cobrink, D, Lee, MH, Hannon, G, Mulligan, G, Bronson, RT, Dyson, N, Harlow, E, Beach, D, Weinberg, RA, Jacks, T. (1996). Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev 10, 1633–1644.

    Article  Google Scholar 

  • DeFriend, DJ, Howell, A, Nicholson, RI, Anderson, E, Dowsett, M, Mansel, RE, Blarney, RW, Bundred, NJ, Robertson, JF, Saunders, C, et al., (1994). Investigation of a new pure anti-estrogen (ICI 182780) in women with primary breast cancer. Cancer Res. 54, 408–414.

    CAS  PubMed  Google Scholar 

  • Ewen, ME, Sluss, HK, Sherr, CJ, Matsushime, H, Kato, J, and Livingstone, DM. (1993). Functional interaction of the retinoblastoma protein with mammalian D-type cyclins. Cell 73, 487–497.

    Article  CAS  PubMed  Google Scholar 

  • Fang, F, Orend, G, Watanabe, N, Hunter, T, Ruoslahti, E. (1996). Dependence of cyclin E-CDK2 kinase activity on cell anchorage. Science, 271, 499–501.

    Article  CAS  PubMed  Google Scholar 

  • Fantl, V, Stamp, G, Andrews, A, Rosewell, I, and Dickson, C (1995). Mice lacking cyclin D1 are small and show defects in eye and mammary gland development. Genes & Development 9, 2364–2372.

    Article  CAS  Google Scholar 

  • Foekens, JA, Portengen, H, Look, MP, van Putten, WL, Thirion, B, Bontenbal, M, and Klijn, JG. (1994). Relationship of pS2 with response to tamoxifen therapy in patients with recurrent breast cancer. Br J Cancer 70, 1217–1223.

    Article  CAS  PubMed  Google Scholar 

  • Fracchiolla, NS, Pruneri, G, Pignataro, L, Carboni, N, Capaccio, P, Boletini, A, Buffa, R, Neri, A. (1997). Molecular and immunohistochemical analysis of the bel-1/cyclin D1 gene in laryngeal squamous cell carcinomas. Cancer 79, 6, 1114–1121.

    Article  CAS  PubMed  Google Scholar 

  • Gillett, CE, Fantl, V, Smith, R, Fisher, C, Bartek, J, Dickson, C, Barnes, D and Peters, G (1994). Amplification and over-expression of cyclin D1 in breast cancer detected by immunohistochemical staining. Cancer Res. 54, 1812–1817.

    CAS  PubMed  Google Scholar 

  • Gillett, C, Smith, P, Gregory, W, Richards, M, Millis, R, Peters, G, Barnes, D. (1996). Cyclin D1 and prognosis in human breast cancer. Int J Cancer (Pred Oncol) 69, 92–99.

    Article  CAS  Google Scholar 

  • Guadagno, TM, Ohtsubo, M, Roberts, JM, Assoian, RK. (1993). A link between cyclin A expression and adhesion-dependent cell cycle progression. Science 262, 1572–1575.

    Article  CAS  PubMed  Google Scholar 

  • Hall, M, and Peters, G. (1996). Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv. Cancer Res 68, 67–108.

    Article  CAS  PubMed  Google Scholar 

  • Herber, B, Truss, M, Beato, M, Müller, R. (1994). Inducible regulatory elements in the human cyclin D1 promoter. Oncogene 9, 2105–2107.

    CAS  PubMed  Google Scholar 

  • Herrera, RE, Sah, VP, Williams, BO, Makela, TP, Weinberg, RA, Jacks, T. (1996). Altered cell cycle kinetics, gene expression, and G1 restriction point regulation in Rb-deficient fibroblasts. Mol Cell Biol 16, 2402–2407.

    CAS  PubMed  Google Scholar 

  • Hinds, PW, Dowdy, SF, Eaton, EN, Arnold, A, Weinberg, RA. (1994). Function of a human cyclin gene as an oncogene. Proc Natl Acad Sci USA 91, 709–713.

    Article  CAS  PubMed  Google Scholar 

  • Hunter, T. (1997). Oncoprotein networks. Cell 88, 333–346.

    Article  CAS  PubMed  Google Scholar 

  • Ignar-Trowbridge, DM, Teng, CT, Ross KA, Parker, MG, Korach, KS, McLachlan, JA. (1993). Peptide growth factors elicit estrogen receptor-dependent transcriptional activation of an estrogen-responsibe element. Mol. Endocrinol 7, 992–998.

    Article  CAS  PubMed  Google Scholar 

  • Jordan, VC and Murphy, CS (1990). Endocrine pharmacology of anti-estrogens as antitumor agents. Endocr Rev 11, 578–610.

    Article  CAS  PubMed  Google Scholar 

  • Kato, S, Endoh, H, Masuhiro, Y, Kitamoto, T, Uchiyama, S, Sasaki, H, Masushige, S, Gotoh, Y, Nishida, E, Kawashima, H, Metzger, D, and Chambon, P. (1995). Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase. Science 270, 1491–1494.

    Article  CAS  PubMed  Google Scholar 

  • Katzenellenbogen, BS, Miller, MA, Mullick, A, and Sheen, YY (1985). Anti-estrogen action in breast cancer cells: modulation of proliferation and protein synthesis, and interaction with estrogen receptors and additional anti-estrogen binding sites. Breast Cancer Res Treat 5, 231–243.

    Article  CAS  PubMed  Google Scholar 

  • Kitagawa, M, Higashi, H, Jung, H-K, Suzuki-Takahashi, I, Ikeda, M, Tamai, K, Kato, J, Segawa, K, Yoshida, E, Nishimura, S and Tay, Y. (1996). The consensus motif for phosphorylation by cyclin Dl-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 15, 7060–7069.

    CAS  PubMed  Google Scholar 

  • Klijn, JG, Berns, EM, and Foekens, JA (1993). Prognostic factors and response to therapy in breast cancer. Cancer Surv 18, 165–198.

    CAS  PubMed  Google Scholar 

  • Lukas, J, Bartkova, J, Bartek, J. (1996). Convergence of mitogenic signalling cascades from diverse classes of receptors on the cyclin D/cdk-pRb-controlled G1 checkpoint. Mol Cell Biol 16, 6917–6925.

    CAS  PubMed  Google Scholar 

  • Masuda, M, Hirakawa, N, Nakashima, T, Kuratomi, Y, Komiyama, S. (1996). Cyclin D1 overexpression in primary hypopharyngeal carcinomas. Cancer 78, 3, 390–395.

    Article  CAS  PubMed  Google Scholar 

  • McIntosh GG, Anderson JJ, Milton I, Steward M, Parr AH, Thomas MD, Henry JA, Angus B, Lennard TW, Home CH. (1995). Determination of the prognostic value of cyclin D1 overexpression in breast cancer. Oncogene 11, 885–891.

    CAS  PubMed  Google Scholar 

  • Meredith, SD, Levine, PA, Burns, JA, Gaffey, MJ, Boyd, JC, Weiss, LM, Erickson, NL, Williams, ME. (1995). Chromosome 11q13 amplification in head and neck squamous cell carcinoma. Arch Otolaryngol Head and Neck Surg 121, 790–794.

    Article  CAS  Google Scholar 

  • Metzger, D, Berry, M, Ali, S, and Chambon, P. (1995). Effect of antagonists on DNA binding properties of the human estrogen receptor in vitro and in vivo. Mol Endocrin 9, 579–591.

    Article  CAS  Google Scholar 

  • Michalides, R, van Veelen, N, Hart, A, Loftus, B, Wientjens, E, and Balm, A. (1995). Overexpression of cyclin D1 correlates with recurrence in a group of forty-seven opearble squamous cell carcinomas of the head and neck. Cancer Res 55, 975–978.

    CAS  PubMed  Google Scholar 

  • Michalides, R, Hageman Ph, Tinteren H van, Houben L, Wientjens E, Klompmaker R, Peterse J. (1996). Aclinicopathological study on overexpression of cyclin D1 and of p53 in a series of 248 patients with operable breast cancer. Br J Cancer 73, 728–734.

    Article  CAS  PubMed  Google Scholar 

  • Michalides, R, van Veelen, N, Kristel, P, Hart, A, Loftus B, Hilgers, F, and Balm, A.(1997). Overexpression of cyclin D1 indicates a poor prognosis in squamous cell carcinoma of the head and neck. Arch Oto Head and Neck Surg, in press.

    Google Scholar 

  • Mushgrove, EA, Hamilton, JA, Lee, CS, Sweeney, KJ, Watts, CK, and Sutherland, RL (1993). Growth factor, steroid, and steroid antagonist regulation of cyclin gene expression associated with changes in T-47D human breast cancer cell cycle progression. Mol Cell Biol 13, 3577–3587.

    Google Scholar 

  • Mushgrove EA, Lee CLE, Buckley MF, Sutherland RL. (1994). Cyclin D1 induction in breast cancer cells shortens the G1 and is sufficient for cells arrested in G1 to complete the cell cycle. Proc Natl Acad Sci USA 91, 8022–8026.

    Article  Google Scholar 

  • Ohtsubo, M, Theodoras, AM, Schumacher, J, Roberts, JM, Pagano, M. (1995). Human cyclin E, a nuclear protein essential for the G1-to-S-phase transition. Mol Cell Biol 15, 2612–2624.

    CAS  PubMed  Google Scholar 

  • Ohtani, K, DeGregori, J, Nevins, JR. (1995). Regulation of the cyclin E gene by transcripton factor E2F1. Proc Natl Acad Sci USA 92, 12146–12150.

    Article  CAS  PubMed  Google Scholar 

  • Parry, D, Bates, S, Mann, DJ and Peter, G. (1995). Lack of cyclin D-Cdk complexes in Rb-negative cells correlates with high levels of p16INK4/MTS1 tumour suppressor gene product. EMBO J 14, 503–511.

    CAS  PubMed  Google Scholar 

  • Porter, PL, Malone, KE, Heagerty, PJ, Alexander, GM, Gatti, LA, Firpo, EJ, Daling, JR, Roberts, JM. (1997). Expression of cell-cycle regulator p27Kipl and cyclin E, alone and in combination, correlate with survival in young breast cancer patients. Nature Med 3, 2, 222–234.

    Article  CAS  PubMed  Google Scholar 

  • Reese, JC and Katzenellenbogen, BS (1991). Differential DNA-binding abilities of estrogen receptor occupied with two classes of anti-estrogens: studies using human estrogen receptor overexpressed in mammalian cells. Nucleic Acids Res 19, 6595–6602.

    Article  CAS  PubMed  Google Scholar 

  • Resnitzky D, Gossen M, Bujard H, Reed SI. (1994). Acceleration of the G1/S phase transition by expression of cyclins D1 and E with an inducible system. Mol Cell Biol 14, 1669–1679.

    CAS  PubMed  Google Scholar 

  • Resnitzky, D, Reed, SI. (1995). Different roles for cyclins D1 and E in regulation of the G1-to-S transition. Mol Cell Biol 15, 3463–3469.

    CAS  PubMed  Google Scholar 

  • Rimokh, R, Berger, F, Bastard, Chr, Klein, B, French, M, Archimbaud, E, Rousault, JP, Santa Lucia, B, Duret, L, Vuillaume, M, Coiffier, B, Bryon, P.-A, Magaud, J-P. (1994). Rearrangement of CCND1 (BCLI/PRADI)3’ untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias. Blood 83, 12, 3689–3696.

    CAS  PubMed  Google Scholar 

  • Rosenberg, CL, Kim, HG, Shows, TB, Kronenberg, HM, Arnold, A. (1991). Rearrangement and overexpression of D11S287E, a candidate oncogene on chromosome 11q13 in benign parathyroid tumors. Oncogene 6, 449–453.

    CAS  PubMed  Google Scholar 

  • Schulze, A, Zerfass, K, Spitkovsky, D, Middendorp, S, Berges, J, Helin, K, Jansen, Durr, P, Henglein, B. (1995). Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site. Proc Natl Acad Sci USA 92, 11264–11268.

    Article  CAS  PubMed  Google Scholar 

  • Schulze, A, Zerfass-Thome, K, Berges, J, Middendorp, S, Jansen-Durr, P, Henglein, B. (1996). Anchorage-dependent transcription of the cyclin A gene. Mol Cell Biol 16, 9, 4632–4638.

    CAS  PubMed  Google Scholar 

  • Sherr, CJ. (1995). D type cyclins. TIBS 20, 187–190.

    CAS  PubMed  Google Scholar 

  • Sherr, CJ, and Roberts, JM. (1995). Inhibitors of mammalian G1 cyclin-dependent kinases. Genes Dev 9, 1149–1163.

    Article  CAS  PubMed  Google Scholar 

  • Sherr, CJ. (1996). Cancer cell cycles. Science 274, 1672–1677.

    Article  CAS  PubMed  Google Scholar 

  • Sicinski, P, Donaher, JL, Parker, SB, Li, T, Fazeli, A, Gardner, H, Haslam, SZ, Bronson, RT, Elledge, SJ, and Weinberg, RA. (1995). Cyclin D1 provides a link between development and oncogenesis in the retina and breast. Cell 82, 621–630.

    Article  CAS  PubMed  Google Scholar 

  • Smith, CL, Conneely, OM and O’Malley, BW. (1993). Modulation of ligand-indepdent activation of the human estrogen receptor by hormone and antihormone. Proc Natl Acad Sci USA 90, 6120–6124.

    Article  CAS  PubMed  Google Scholar 

  • Sutherland, RL, Watts, CKW, Musgrove, EA. (1993). Cyclin gene expression and growth control in normal and neoplastic human breast epithelium. J Steroid Biochem Molec Biol 47, 99–106.

    Article  CAS  PubMed  Google Scholar 

  • Sweeney, KJ, Sarcevic, B, Sutherland, RL and Musgrove, EA. (1996). Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells. Oncogene 14, 1329–1340.

    Article  Google Scholar 

  • Swerdlow, SH, Yang, W-I, Zukerberg, LR, Harris, NL, Arnold, A, Williams, ME. (1995). Expression of cyclin D1 protein in centrocytic/mantle cell lymphomas with and without rearrangement of the BCL1/cyclin D1 gene. Hum Pathol 26, 9, 999–1004.

    Article  CAS  PubMed  Google Scholar 

  • Thompson, EW, Katz, D, Shima, TB, Wakeling, AE, Lippman, ME, and Dickson, RB. (1989). ICI 164-384 a pure antagonist of estrogen-stimulated MCF-7 cell proliferation and invasiveness. Cancer Res 49, 6929–6934.

    CAS  PubMed  Google Scholar 

  • Wang, TC, Cardiff, RD, Zukerberg, L, Lees, E, Arnold, A, and Schmidt, EV. (1994). Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Nature 369, 669–671.

    Article  CAS  PubMed  Google Scholar 

  • Watts, CKW, Brady, A, Sarcevic, B, DeFazio, A, Musgrove, EA, Sutherland, RL. (1995). Anti-estrogen inhibition of cell cycle progression in breast cancer cells is associated with inhibition of cyclin-dependent kinase activity and decreased retinoblastoma protein phosphorylation. Mol Endocr 9, 1804–1813.

    Article  CAS  Google Scholar 

  • Weinberg, RA. (1995). The retinoblastoma protein and cell cycle control. Cell 81, 323–330.

    Article  CAS  PubMed  Google Scholar 

  • Weinstat-Saslow, D, Merino, MJ, Manrow, RE, Lawrence, JA, Bluth, RF, Wittenbel, KD, Simpson, JF, Page, DL and Steeg, PS. (1995). Overexpression of cyclin D mRNA distinguishes invasive and in situ breast carcinomas from non-malignant lesions. Nature Med 1, 12, 1257–1260.

    Article  CAS  PubMed  Google Scholar 

  • Weisz, A and Bresciani, F. (1988). Estrogen induces expression of c-fos and c-myc protooncogenes in rat uterus. Mol Endocrinol 2, 816–824.

    Article  CAS  PubMed  Google Scholar 

  • Weisz, A and Rosales, R. (1990). Identification of an estrogen response element upstream of the human c-fos gene that binds the estrogen receptor and the AP-1 transcription factor. Nucleic Acids Res 18, 5097–5106.

    Article  CAS  PubMed  Google Scholar 

  • Won, K-A, and Reed, SI. (1996). Activation of cyclin E/Cdk2 is coupled to site-specific autophosphorylation and ubiquitin-dependent degradation of cyclin E. EMBO J 15, 16, 4182–4193.

    CAS  PubMed  Google Scholar 

  • Zhang, T, Nanney, LB, Luongo, C, Lamps, L, Heppner, KJ, DuBois, RN and Beauchamp, RD. (1997). Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (min) mice and human familial adenomatous polyposis patients. Cancer Res 57, 169–175.

    CAS  PubMed  Google Scholar 

  • Zwijsen, R, Klompmaker, R, Wientjens, E, Kristel, P, van der Burg, B, and Michalides, R. (1996). Cyclin D1 triggers autonomous growth of breast cancer cells by governing the cell cycle exit. Mol Cell Biol 16, 2554–2560.

    CAS  PubMed  Google Scholar 

  • Zwijsen, RML, Wientjens, E, Klompmaker, R, Sman, J van der, Bernards, R, Michalides, RJAM. Ligand-independent activation of ER-responsive gene transcription by cyclin Dl. (1997) Cell 88, 405–415.

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX, Amsterdam, The Netherlands

    Rob Michalides

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  1. Rob Michalides
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  1. Roswell Park Cancer Institute, Buffalo, New York, USA

    Enrico Mihich

  2. Kimmel Cancer Institute, Philadelphia, Pennsylvania, USA

    Carlo Croce

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Michalides, R. (1998). Deregulation of Cyclin D1 in Cancer. In: Mihich, E., Croce, C. (eds) The Biology of Tumors. Pezcoller Foundation Symposia, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1352-4_12

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  • DOI: https://doi.org/10.1007/978-1-4899-1352-4_12

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