Abstract
Over the last twenty years the number of known protein structures has risen exponentially. However, there are still at least tenfold more proteins whose sequences are known but whose structures have not yet been determined. For these proteins, information about sequence/structure relationships are used to predict a probable structure. This can include residue preferences for specific secondary structure conformations or residue contact potentials. It is critically important, though, that any statistically based study, to derive such information, should use a non-degenerate dataset. That is, a set which contains a single representative from each of the protein fold families.
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Orengo, C.A., Flores, T.P., Taylor, W.R., Thornton, J.M. (1994). Protein Fold Families and Structural Motifs. In: Doniach, S. (eds) Statistical Mechanics, Protein Structure, and Protein Substrate Interactions. NATO ASI Series, vol 325. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1349-4_23
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DOI: https://doi.org/10.1007/978-1-4899-1349-4_23
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