Abstract
Valproic acid (VPA), the structure of which is shown as Figure 1, was first synthesised by Burton in 1862 [1], but its pharmacological importance remained undiscovered until 1963, when Meunier [2] showed, almost by accident, that VPA has anti-convulsant activity, with a broad spectrum of anti-epileptic activity. The mechanism of action of VPA is not fully understood, but it is thought to be related in some way to altered levels of gamma aminobutyric acid (GABA), which is an inhibitory neurotransmitter in the brain [3].
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Dale, A.D., Turner, S.E. (1994). A Note on the Analysis of Valproic Acid in Human Plasma Using an Automated Sample Preparation Device (ASTED). In: Stevenson, D., Wilson, I.D. (eds) Sample Preparation for Biomedical and Environmental Analysis. Chromatographic Society Symposium Series. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1328-9_13
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DOI: https://doi.org/10.1007/978-1-4899-1328-9_13
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