Initial Measurements of Platinum Concentration in Head and Neck Tumors Using X-Ray Fluorescence

  • Parvaiz A. Ali
  • D. Geraint Lewis
  • Ahmed M. El-Sharkawi
  • Fahd A. Al-Sadhan
  • Colin J. Evans
  • Donald A. Hancock
  • Jack Dutton
Part of the Basic Life Sciences book series (BLSC, volume 60)

Abstract

Currently there is no noninvasive technique generally available in oncology that can discriminate adequately between tumors that are likely to respond to platinum compounds and those that are not. Recently, however, it has been shown that platinum can be measured in vivo,at concentration levels of interest, by the method of X-ray fluorescence1,2 (XRF). It follows that, because the concentration of a drug at its site of action is the principal determinant of response, the application of this method would be of value in obtaining direct pharmacodynamic information about the drug and give the prospect of optimizing the therapeutic ratio.

Keywords

Platinum Platinum Solution Paraplatin 

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References

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Parvaiz A. Ali
    • 2
  • D. Geraint Lewis
    • 3
  • Ahmed M. El-Sharkawi
    • 1
  • Fahd A. Al-Sadhan
    • 3
  • Colin J. Evans
    • 3
  • Donald A. Hancock
    • 2
  • Jack Dutton
    • 3
  1. 1.Swansea In Vivo Analysis Research Group Department of Radiotherapy and OncologySingleton HospitalSwansea, WalesUK
  2. 2.Department of Medical Physics and Clinical EngineeringSingleton HospitalSwansea, WalesUK
  3. 3.Department of PhysicsUniversity CollegeSwansea, WalesUK

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