Feto-Maternal Thyroid Hormone Relationships in Iodine Deficiency: An Experimental Approach

  • Gabriella Morreale de Escobar
  • María Jesús Obregón
  • Rosa Calvo
  • Francisco Escobar del Rey
Chapter
Part of the NATO ASI Series book series (NSSA, volume 241)

Abstract

The multiple mechanisms which permit compensatory adaptation of the thyroid gland to severe and chronic iodine deficiency (ID) are known since many years. As a result there is a shift in the synthesis of T4 in favour of T3 and a preferential secretion of T3 over T4, so that with very little iodine normal circulating T3 is maintained despite very low T4. Overt clinical hypothyroidism is not apparent and is attributed to the normal serum T3. Here we will summarize information regarding extrathyroidal responses to ID in the rat, with special attention to the fetus and newborn and its brain during early development, as studied in our laboratory.

Keywords

Iodine Hypothyroidism Azole Perchlorate Thyroxine 

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Copyright information

© Springer Science+Business Media New York 1993

Authors and Affiliations

  • Gabriella Morreale de Escobar
    • 1
  • María Jesús Obregón
    • 1
  • Rosa Calvo
    • 1
  • Francisco Escobar del Rey
    • 1
  1. 1.Unidad de Endocrinología MolecularInstituto de Investigaciones Biomédicas & Facultad de Medicina, CSIC & UAMMadridSpain

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