HLA-DR, DQ System and IDDM in Japanese
The genetic factors involved in the development of insulin-dependent diabetes mellitus (IDDM) have been found to be associated with genes in the major histocompatibility complex (MHC) located on chromosome 6. DQ antigens appear to be the most relevant for the development of IDDM: HLA-DQw2 and DQw3 in Caucasians1,2 and HLA-DQw4 and DQw9 in Japanese.3 Moreover, position 57 of the DQβ chain and position 52 of the DQα chain were found to be associated with IDDM susceptibility in Caucasians. Homozygosity for non-aspartic acid (non-Asp-57) was observed in 90% of the IDDM patients and none were homozygous for aspartic acid (Asp-57).2,5
KeywordsRestriction Fragment Length Polymorphism Antigen Binding Site DRB1 Gene Allele Specific Oligonucleotide 57th Residue
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