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HLA-DR, DQ System and IDDM in Japanese

  • Nobuo Matsuura
  • Juan M. R. Aparicio
  • Akemi Wakisaka
Part of the NATO ASI Series book series (NSSA, volume 270)

Abstract

The genetic factors involved in the development of insulin-dependent diabetes mellitus (IDDM) have been found to be associated with genes in the major histocompatibility complex (MHC) located on chromosome 6. DQ antigens appear to be the most relevant for the development of IDDM: HLA-DQw2 and DQw3 in Caucasians1,2 and HLA-DQw4 and DQw9 in Japanese.3 Moreover, position 57 of the DQβ chain and position 52 of the DQα chain were found to be associated with IDDM susceptibility in Caucasians. Homozygosity for non-aspartic acid (non-Asp-57) was observed in 90% of the IDDM patients and none were homozygous for aspartic acid (Asp-57).2,5

Keywords

Restriction Fragment Length Polymorphism Antigen Binding Site DRB1 Gene Allele Specific Oligonucleotide 57th Residue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Nobuo Matsuura
    • 1
    • 2
  • Juan M. R. Aparicio
    • 3
  • Akemi Wakisaka
    • 3
  1. 1.Pediatric ClinicTonan General HospitalSapporoJapan
  2. 2.Diabetes CenterTokyo Women’s Medical CollegeTokyoJapan
  3. 3.Department of PathologyHokkaido University School of MedicineSapporoJapan

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