HLA-DR, DQ System and IDDM in Japanese

  • Nobuo Matsuura
  • Juan M. R. Aparicio
  • Akemi Wakisaka
Part of the NATO ASI Series book series (NSSA, volume 270)


The genetic factors involved in the development of insulin-dependent diabetes mellitus (IDDM) have been found to be associated with genes in the major histocompatibility complex (MHC) located on chromosome 6. DQ antigens appear to be the most relevant for the development of IDDM: HLA-DQw2 and DQw3 in Caucasians1,2 and HLA-DQw4 and DQw9 in Japanese.3 Moreover, position 57 of the DQβ chain and position 52 of the DQα chain were found to be associated with IDDM susceptibility in Caucasians. Homozygosity for non-aspartic acid (non-Asp-57) was observed in 90% of the IDDM patients and none were homozygous for aspartic acid (Asp-57).2,5


Restriction Fragment Length Polymorphism Antigen Binding Site DRB1 Gene Allele Specific Oligonucleotide 57th Residue 
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  1. 1.
    H. Festenstein, J. Awad, G.A. Hitman, et al., New HLA DNA polymorphisms associated with autoimmune disease, Nature 322:64, 1986.PubMedCrossRefGoogle Scholar
  2. 2.
    J.A. Todd, J.I. Bell, H.O. McDevitt, HLA-DQ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus, Nature 329:599, 1987.PubMedCrossRefGoogle Scholar
  3. 3.
    R.J. Aparicio, A. Wakisaka, A. Takeda, et al., HLA-DQ system and insulin-dependent diabetes mellitus in Japanese: Does it contribute to the development of IDDM as it does in Caucasians?, Immunogenetics 28:240, 1988.PubMedCrossRefGoogle Scholar
  4. 4.
    I. Khalil, L. d’Auriol, M. Gobet, et al., A combination of HLA-DQß Asp-57-negative and HLA DQα Arg-52 confers susceptibility to insulin-dependent diabetes mellitus, J Clin Invest 85:1315, 1990.PubMedCrossRefGoogle Scholar
  5. 5.
    P.A. Morel, J.S. Dorman, J.A. Todd, et al., Aspartic acid at position 57 of the HLA-DQß chain protects against Type I diabetes: A family study, Proc Natl Acad Sci. USA 85:8111, 1988.PubMedCrossRefGoogle Scholar
  6. 6.
    J.A. Todd, C. Mijovic, J. Fletcher, et al., Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping, Nature 338:587, 1989.PubMedCrossRefGoogle Scholar
  7. 7.
    J.A. Todd, T. Fukui, T. Kitagawa, et al., The A3 allele of the HIA-DQA1 locus is associated with susceptibility to Type I diabetes in Japanese, Proc Natl Acad Sci. USA 87:1094, 1990.PubMedCrossRefGoogle Scholar
  8. 8.
    H.J. Brown, T. Jardetzky, M.A. Saper, et al., A hypothetical model of the foreign antigen binding site of class II histocompatibility molecules, Nature 332:854, 1988.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1994

Authors and Affiliations

  • Nobuo Matsuura
    • 1
    • 2
  • Juan M. R. Aparicio
    • 3
  • Akemi Wakisaka
    • 3
  1. 1.Pediatric ClinicTonan General HospitalSapporoJapan
  2. 2.Diabetes CenterTokyo Women’s Medical CollegeTokyoJapan
  3. 3.Department of PathologyHokkaido University School of MedicineSapporoJapan

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