Abstract
Substantial data have been collected concerning the incidence of IDDM in different countries and ethnic groups, showing large geographic variability. The incidence of IDDM is highest in Finland, 42.9 new cases per 100,000 children under 15 years of age per year,1 whereas the lowest rates are in Far East countries, less than 1/100,000per year in Japan and Korea.2
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References
A. Green, E.A.M. Gale, C.C. Patterson, for the EURODIAB ACE Study Group, Incidence of childhood-onset insulin-dependent diabetes mellitus: The Eurodiab Ace study, Lancet 339:905 (1992).
M.Z. Bao, J.X. Wang, J.S. Dorman, M. Trucco, HLA-DQ beta non-Asp-57 allele and incidence of diabetes in China and the U.S.A., Lancet 2:297 (1989).
R.E. LaPorte, N. Tajima, H.K. Akerblom, Geographic differences in the risk of insulin-dependent diabetes mellitus: The importance of registries, Diabetes Care 8 (suppl.):101 (1985).
E. Schober, H. Frish, Incidence of childhood diabetes mellitus in Austria 1979–1984, Acta Paediatr Scand. 77:299 (1988).
G. Soltész, L. Madacsy, D. Bekefi, I. Danko, The Hungarian Childhood Diabetes Epidemiology Group, Rising incidence of Type I diabetes in Hungarian children (1978–1987), Diabetic Med. 7:111 (1990).
C. Levy-Marchal, L. Papoz, C. de Beaufort, Incidence of juvenile Type I (insulin-dependent) diabetes mellitus in France, Diabetologia 33:465 (1990).
Diabetes Epidemiology Research International Group, Geographic patterns of childhood insulin-dependent diabetes mellitus, Diabetes 37:1113 (1988).
L. Nystrom, G. Dahlquist, M. Rewers, S. Wall, The Swedish Childhood Diabetes study. An analysis of the temporal variation in diabetes incidence 1978–1987, Int J Epidemiol. 19:141 (1990).
Diabetes Epidemiology Research International (DERI) Study Group, The epidemiology and immunogenetics of IDDM in Italian-heritage populations, Diabetes Metab Rev. 6:63 (1990).
Diabetes Epidemiology Research International group, Secular trends in incidence of childhood IDDM in 10 countries, Diabetes 39:858 (1990).
H. Lestardet, J. Besse, Prevalence et incidence du diabete juvenile insulino-dependant en France, Diabete Metab. 3:229 (1977).
G. Roglic, Z. Metelko, M. Kadrnka-Lovrencic, M. Granic, Z. Skrabalo, Incidence of insulin-dependent diabetes mellitus — The Zagreb registry, 14th International Diabetes Federation Congress, Abstracts 1274 (1991).
Diabetes Epidemiology Research International Study Group, Childhood diabetes in Arab countries, Bull WHO 68:231 (1990).
P.A. Morel, J.S. Dorman, J.A. Todd, H.O. McDevitt, M. Trucco, Aspartic acid at position 57 of the HLA-DQ beta chain protects against Type I diabetes: A family study, Proc Natl Acad Sci. USA 85:8111 (1988).
H. Reijonen, J. Ilonen, M. Knip, A.K. Hans, HLA-DQB1 alleles and absence of Asp 57 as susceptibility factors of IDDM in Finland, Diabetes 40:1640–1644 (1991).
M. Trucco, To be or not to be Asp 57, that is the question, Diabetes Care 15:705 (1992).
M. Trucco, J.S. Dorman, Immunogenetics of insulin-dependent diabetes mellitus in humans, Critical Rev Immunol. 9:201 (1989).
M. Kocova, W.A. Rudert, E.P. Weisberg, M. Trucco, J.S. Dorman, D.J. Pettit, W.C. Knowler, HLA class II molecular genotypes in Pima Indians: Rarity of IDDM susceptibility alleles, Submitted.
J.S. Dorman, R.E. LaPorte, R.A. Stone, M. Trucco, Worldwide differences in the incidence of Type I diabetes are associated with amino acid variation at position 57 of the HLA-DQ beta chain, Proc Natl Acad Sei. USA 87:7378 (1990).
WHO DIAMOND Project Group: WHO Multinational Project for Childhood Diabetes, Diabetes Care 13:1062 (1990).
R.J. Vergona, Computer program for IDDM registries, Diabetes Care 14:70 (1990).
R. Sorrentino, U. DeGrazia, R. Buzzeti, L. Nistico, C. Iannicola, S. Costanzi, R. Tosi, An explanation for the neutral effect of DR2 on IDDM susceptibility in central Italy, Diabetes 41:904 (1992).
P.J. Bingley, E.A. Gale, Rising incidence of IDDM in Europe, Diabetes Care 12:289 (1989).
G.J. Vaandrager, G.J. Bruining, F.J. Veenhof, N.M. Drayer, Incidence of childhood diabetes in the Niderlands: A decrease from north to south over North-Western Europe? Diabetologia 27:203 (1984).
C. Carcassi, G. Trucco, M. Trucco, L.A. Contu, New HLA-DR2 extended haplotype is involved in insulin-dependent diabetes mellitus susceptibility, Hum Immunol. 31:159 (1991).
D. Zeliszewski, J.M. Tiercy, C. Boitard, X.F. Gu, M. Loche, R. Krishnamoorthy, N. Simmoney, J. Elion, J.F. Bach, B. Mach, G. Sterkers, Extensive study of DRB, DQA, and DQB gene polymorphism in 23 DR2-positive insulin-dependent diabetes mellitus patients, Hum Immunol 33:140 (1992).
M. Kocova, M. Trucco, M. Konstantinova, J.S. Dorman, A “cold-spot” of IDDM incidence in Europe, Diabetes Care 16:1236 (1993).2
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Kocova, M. et al. (1994). The Incidence of IDDM and Molecular HLA-DQB1 Typing in Macedonian Children. In: Dorman, J.S. (eds) Standardization of Epidemiologic Studies of Host Susceptibility. NATO ASI Series, vol 270. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1213-8_24
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DOI: https://doi.org/10.1007/978-1-4899-1213-8_24
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