Abstract
The concept of liposomes as a drug carrier put forward nearly 25 years ago (Gregoriadis et al, 1971; Gregoriadis and Ryman, 1972a,b), has recently culminated in the marketing of life-saving pharmaceutical products. The story of liposomes and related impact on drug delivery and targeting has been outlined elsewhere (Gregoriadis, 1993). This chapter describes key developments, mostly in my laboratory, which, have contributed to both the unravelling of vesicle fate in vivo and its control. Such developments refer to the manipulation of liposomal structural characteristics with the purpose of ensuring quantitative retention of entrapped drugs by vesicles during their exposure to blood en route to their destination, and of obtaining vesicle clearance rates that contribute to optimal vesicle distribution to target cells and tissues.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Allison, A.C. and Gregoriadis, G., 1974. Liposomes as immunological adjuvants, Nature, 252:252.
Belchetz, P.E., Braidman, I.P., Crawley, J.C.W. and Gregoriadis, G, 1977, Treatment of Gaucher’s disease with liposome-entrapped glucocerebroside-β-glucosidase, Lancet, ii: 116.
Black, C.D.V. and Gregoriadis, G., 1974. Intracellular fate and effect of liposome-entrapped actinomycin D injected into rats, Biochem.Soc.Trans, 2:869.
Black, C.D.V. and Gregoriadis, G., 1976. Interaction of liposomes with blood plasma proteins, Biochem.Soc.Trans., 4:253.
Bonventre, P. and Gregoriadis, G., 1978. Killing of intraphagocytic Staph.aureus by dihydrostreptomycin entrapped in liposomes, Antimicrobial Agents and Chemotherapy, 13:1049.
Gregoriadis, G., 1973. Drug entrapment in liposomes, FEBS Lett., 36:292.
Gregoriadis, G., 1974, Structural requirements for the specific uptake of marcomolecules and liposomes by target tissues, in: “Enzyme Therapy in Lysosomal Storage Disease”, J.M. Tager, G.J.M. Hooghwinkel and W. Th. Daems, eds., North-Holland Publising Co., Leiden.
Gregoriadis, G., 1988, Fate of injected liposomes: Observations on entrapped solute retention, vesicle clearance and tissue distribution in vivo, in; “Liposomes as Drug Carriers: Recent Trends and Progress”, G. Gregoriadis, ed., J. Wiley and Sons Ltd, Chichester.
Gregoriadis, G., 1989. The physiology of the liposome, News in Physiological Sciences, 4:146.
Gregoriadis, G., 1993. Liposomes: A tale in drug targeting, J.Drug Targeting., 1:3.
Gregoriadis, G. and Ryman, B.E., 1972a, Fate of protein-containing liposomes injected into rats. An approach to the treatment of storage diseases, Eur.J.Biochem., 24:485.
Gregoriadis, G. and Ryman, B.E., 1972b, Lysosomal localization of β-fructofuranosidase-containing liposomes injected into rats. Some implications in the treatment of genetic disorders, Biochem.J., 129:123.
Gregoriadis, G. and Buckland, R.A., 1973. Enzyme-containing liposomes alleviate a model for storage disease, Nature, 244:170.
Gregoriadis, G. and Neerunjun, D.E., 1974. Control of the rate of hepatic uptake and catabolism of liposome-entrapped proteins injected into rats. Possible therapeutic applications, Eur.J.Biochem., 47:179.
Gregoriadis, G. and Neerunjun, D.E., 1975. Homing of liposomes to target cells, Biochem. Biophys.Res.Comm., 65:537.
Gregoriadis, G. and Davis, C., 1979. Stability of liposomes in vivo and in vitro is promoted by their cholesterol content and the presence of blood cells, Biochem.Biophys. Res.Comm., 89:1287.
Gregoriadis, G. and Senior, J., 1980. The phospholipid component of small unilamellar liposomes controls the rate of clearance of entrapped solutes from the circulation, FEBS Lett., 119:43.
Gregoriadis, G., Leathwood, P.D. and Ryman, B.E., 1971. Enzyme entrapment in liposomes, FEBS Lett., 14:95.
Gregoriadis, G., Swain, C.P., Wills, E.J. and Tavill, A.S., 1974, Drug-carrier potential of liposomes in cancer chemotherapy, Lancet, i:1313.
Gregoriadis, G., Neerunjun, D.E. and Hunt, R., 1977. Fate of a liposome-associated agent injected into normal and tumour-bearing rodents. Attempts to improve localization in tumour tissues, Life Sciences, 21:357.
Gregoriadis, G., da Silva, H. and Florence, A.T., 1990. A procedure for the efficient entrapment of drugs in dehydration-rehydration liposomes (DRV), Int.J. Pharmaceutics, 65:235.
Gregoriadis, G., McCormack, B., Wang, Z. and Lifely, R., 1993. Polysialic acids: Potential in drug delivery, FEBS Lett., 315:271.
Juliano, R.L. and Stamp, D., 1975. Effects of particle size and charge on the clearance of liposomes and liposome-encapsulated drugs, Biochem.Biophys.Res.Comm., 63:651.
Kirby, C., Clarke, J. and Gregoriadis, G., 1980, Effect of the cholesterol content of small unilamellar liposomes on their stability in vivo and in vitro, Biochem.J. 186:591.
Klibanov, A.L., Maruyama, K., Torchillin, V.P. and Huang, L., 1990, Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes, FEBS Lett., 268:235.
Krupp, L., Chobanian, A.V. and Brecher, J.P., 1976. The in-vivo transformation of phospholipid vesicles to a particle resembling HDL in the rat, Biochem.Biophys. Res.Comm., 72:1251.
Large, P. and Gregoriadis, G., 1983, Phospholipid composition of small unilamellar liposomes containing melphalan influences drug action in mice bearing PC6 tumours Biochem.Pharmacol., 32:1315.
Loughrey, H.C., Bally, M.B., Reinish, L.W. and Cullis, P.R., 1990. The binding of phosphatidylglycerol liposomes to rat platelets is mediated by complement, Thromb.Haemost., 64:172.
Moghimi, S.M. and Patel, H.M., 1993, Techniques to study the opsonic effect of serum on uptake of liposomes by phagocytic cells from various organs of the RES, in: “Liposome Technology”, 2nd Edition, G. Gregoriadis, ed., CRC Press, Boca Raton.
Papahadjopoulos, D., Cowden, M. and Kimelberg, H., 1973. Role of cholesterol in membranes. Effect of phospholipid-protein interactions, membrane permeability and enzyme activity, Biochim.Biophys.Acta, 310:8.
Papahadjopoulos, D., Allen, T., Gabizon, A., Mayhew, E., Matthay, K., Huang, K., Lee, S.K., Woodle, M.C., Lasic, D.D., Redemann, C. and Martin, F.J., 1991. Sterically stabilized liposomes: improvements in pharmacokinetics, tissue disposition and anti-tumour therapeutic efficacy, Proc.Natl.Acad.Sci.USA, 88:11460.
Richards, R.L., Gewurz, H., Seigel, J. and Alving, C.R., 1979. Interaction of C-reactive protein and complement with liposomes, J.Immunol., 112:1185.
Rossi, J.D. and Wallace, B.A., 1983. Binding of fibronectin to phospholipid vesicles, J.Biol.Chem., 258:3327.
Saba, T.M., 1970. Physiology and physiopathology of the reticulo-endothelial system, Arch.Intern.Med., 126:1031.
Segal, A.W., Wills, E.J., Richmond, J.E., Slavin, G., Black C.D.V. and Gregoriadis, G., 1974. Morphological observations on the cellular and subcellular destination of intravenously administered liposomes, Brit.J.Exp.Pathol., 55:320.
Senior, J.H., Delgado, C., Fisher, D., Tilcock C. and Gregoriadis, G., 1991, Influence of surface hydrophilicity of liposomes on their interaction with plasma proteins and clearance from the circulation: Studies with polyethylene glycol-coated vesicles Biochim.Biophys.Acta, 1062:77.
Scherphof, G., Roerdink, G., Waite, M. and Parks, J., 1978. Disintegration of phosphatidylcholine liposomes in plasma an a result of interaction with high-density lipoproteins, Biochim.Biophys.Acta, 542:296.
Tan, L. and Gregoriadis, G., 1989, The effect of positive surface charge of liposomes on their clearance from blood and its relation to vesicle lipid composition Biochem.Soc.Trans., 17:690.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1994 Springer Science+Business Media New York
About this chapter
Cite this chapter
Gregoriadis, G. (1994). Liposomes In Vivo: Control of Behaviour. In: Gregoriadis, G., McCormack, B., Poste, G. (eds) Targeting of Drugs 4. NATO ASI Series, vol 273. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1207-7_9
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1207-7_9
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1209-1
Online ISBN: 978-1-4899-1207-7
eBook Packages: Springer Book Archive