Abstract
The Drug Delivery Research Group at the University of Nottingham has for a number of years been interested in the development of a wide variety of systems for site specific drug delivery to include micro and nanospheres, polymers and prodrugs. This paper will focus especially on the use of colloidal carriers such as nanospheres, emulsions and liposomes to achieve site specific delivery of drugs to sites in the body such as the lungs, liver, spleen, the general circulation, the lymphatics, the bone marrow and the joint cavities after parenteral administration. Microspheres administered by non-parenteral routes of administration will further have the ability of targeting to the lungs, the nasal cavity and the gastrointestinal tract. The use of the gastrointestinal tract is of special importance for vaccine delivery and for the exploitation of bioadhesive particles to modify gastrointestinal transit.
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References
Alving, C.R., 1983. Delivery of liposome-encapsulated drugs to macrophages, Pharm. Ther., 22:407.
van Berkel, T.J.C., Kruijt, J.K., Harkes, L., Nagelkerke, J.F., Spanjer, H. and Kempen, H.-J. M., 1993, Receptor-dependent targeting.
Boddy, A.V. and Aarons, L.J., 1991. Application of a linear recirculation model to drug targeting, J.Pharmacokinet.Biopharm., 19:355.
Brindley, A., Davies, M.C., Lynn, R.A.P, Davis, S.S., Hearn, J. and Watts, J.F., 1992. The surface characterization of model charged and sterically stabilized polymer colloids by SSIMS and X.P.S., Polymer Reports, 33:1112.
Brindley, A., Davis, S.S., Davies, M.C. and Watts, J.F., Polystyrene colloids with surface grafted poly(ethylene oxide) as model systems for site specific drug delivery. Part 1: Preparation and surface chemical characterisation using SIMS and XPS, J.Colloid Interf.Sci., in press.
Davis, S.S. and Ilium, L., 1986, Colloidal delivery systems: opportunities and challenges, in: “Site-specific drug delivery”, E. Tomlinson and S.S. Davis, eds., John Wiley & Sons, Chichester.
Davis, S.S., Ilium, L., Moghimi, S.M., Davies, M.C., Porter, C.J.H., Muir, I.S., Brindley, A., Christy, N.M., Norman, M.E., Williams, P. and Dunn, S., 1993. Microspheres for targeting drugs to specific body sites, J.Control.Rel., 24:157.
Davis, S.S., 1993, Oral delivery of peptides and proteins, in: “Perspectives in Medicinal Chemistry”, B. Testa, E. Kyburz, W. Fuher and R. Giger, eds., VCH, Weinheim.
Dunn, S.E., Brindley, A., Davis, S.S., Davies, M.C. and Ilium, L., Polystyrene-poly(ethylene glycol) (PS-PEG 2000) particles as model systems for site specific drug delivery. Part 2. The effect of PEG surface density on the in vivo cell interaction and in vivo biodistribution, Pharm.Res., in press.
Harper, G.R., Davis, M.C., Davis, S.S., Tadros, Th.F., Taylor, D.C., Irving, M.P. and Waters, J.A., 1991. Steric stabilization of microspheres with grafted polyethylene oxide reduces phagocytosis by rat Kupffer cells in vitro, Biomaterials, 12:695.
Ilium, L. and Davis, S.S., 1987. Targeting of colloidal particles to the bone marrow, Life Sci., 40:1553.
Ilium, L., Wright, J. and Davis, S.S., 1989. Targeting of microspheres to sites of inflammation, Int.J.Pharm., 52:221.
Ilium, L., Davis, S.S., Muller, R.H., Mak, E. and West, P., 1987. The organ distribution and circulation time of intravenously injected colloidal carriers sterically stabilized with a block co-polymer-poloxamine 908, Life Sci., 40:367.
Ilium, L., Davis, S.S., 1984. The organ uptake of intravenously administered colloidal particles can be altered using a non-ionic surfactant (Poloxamer 338), FEBS Lett., 167:79.
Jeon, S.I., Lee, J.H., Andrade, J.D. and de Gennes, P.G., 1991. Protein-surface interactions in the presence of polyenthylene oxide, J.Colloid Interf.Sci., 142:149.
Jenkins, P.G., Howard, K.A., Blackhall, N.W., Thomas, N.W., Davis, S.S. and O’Hagan, D.T., 1994. Microparticulate absorption from the rat intestine, J.Control.Rel., 29:339.
Klibanov, A.L., Maruyama, K., Torchillin, V.P. and Huang, L., 1990. Amphipathic polyenthyleneglycols effectively prolong the circulation time of liposomes, FEBS Lett., 268:235.
Leonard, E.F. and Vroman, L., 1991. Is the Vroman effect of importance in the interaction of blood with artificial materials?, J.Biomater.Sci.Polym.Ed., 3:95.
Mizushima, Y., Hamano, T. and Yokoyama, K., 1982. Use of a lipid emulsion as a novel carrier for corticosteroids, J.Pharm.Pharmacol., 34:49.
Moghimi, S.M. and Patel, H.M., 1992. Opsonophagocytosis of liposomes by peritoneal macrophages and bone marrow reticuloendothelial cells, Biochim.Biophys.Acta, 1135:269.
Moghimi, S.M., Hawley, A.E., Christy, N.M., Gray, T., Ilium, L. and Davis, S.S., 1994. Surface engineered nanospheres with enhanced drainage into lymphatics and uptake by macrophages of the regional lymph nodes, FEBS Lett., 344:25.
Moghimi, S.M., Muir, I.S., Ilium, L., Davis, S.S. and Kolb-Bachofen, V., 1993. Coating particles with a block co-polymer (poloxamer 908) suppresses opsonisation but permits the activity of dysopsonins in the serum, Biochim.Biophys.Acta, 1179:157.
Moghimi, S.M., Porter, C.J.H., Muir, I.S., Ilium, L. and Davis, S.S., 1991. Non-phagocytic uptake of intravenously injected microspheres in rat spleen: Influence of particle size and hydrophilic coating, Biochem.Biophys.Res.Commun., 177:861.
Moghimi, S.M. and Patel, H.M., 1989. Differential properties of organ-specific serum opsonins for liver and spleen macrophages, Biochim.Biophys.Acta, 984:379.
Muir, I.S., Moghimi, S.M., Ilium, L., Davis, S.S. and Davies, M.C., 1991. The effect of block copolymer on the uptake of model polystyrene microspheres by Kupffer cells — in vitro and in vivo studies, Biochem.Soc.Trans., 19:3295.
Norman, M.E., Williams, P. and Ilium, L., 1992. Human serum albumin as a probe for surface conditioning (opsonization) of block copolymer-coated microspheres, Biomaterials, 13:841.
Norman, M.E., Williams, P. and Ilium, L., 1993. The adsorption of plasma and serum proteins to block copolymer coated microspheres, Biomaterials, 14:193.
O’Hagan, D.T., 1990. Intestinal translocation of particulates — implications for drug and antigen delivery, Adv.Drug Deliv., 5:265.
Porter, C.J.H., Moghimi, S.M., Ilium, L. and Davis, S.S., 1992. The polyoxyethylene/ polyoxypropylene block co-polymer poloxamer-407 selectively redirects intravenously injected microspheres to sinusoidal endothelial cells of rabbit bone marrow, FEBS Lett., 305:62.
Posnansky, M.J. and Juliano, R.L., 1984. Biological approaches to the controlled delivery of drugs; a critical review, Pharmacol.Rev., 36:277.
Stolnik, S., Davies, M.C., Ilium, L., Davis, S.S., Boustra, M. and Vert, M., 1993, The preparation of sub 200 nm biodegradable colloidal carriers from poly(β-malic acid-co-benzyl malate) copolymers and their surface modification with Poloxamer and Poloxamine surfactants, J.Control.Rel., in press.
Tomlinson, E. and Davis, S.S., 1986, “Site Specific Drug Delivery”, eds., Wiley, Chichester.
Toth, C.A. and Thomas, P., 1992. Liver endocytosis and Kupffer cells, Hepatology, 16:255.
Vanchieri, C., 1993. Opportunities opening up for Gene Therapy, J.Nat.Cancer Inst., 85:90.
Yitols, S.G., Masquelier, M. and Peterson, C.O., 1985. Selective uptake of a toxic lipophilic anthracycline derivative by the low-density lipoprotein receptor pathway in cultured fibroblasts, J.Med.Chem., 28:451.
Weinstein, J.N. and Leserman, L.D., 1984. Liposomes as drug carriers in cancer chemotherapy, Pharmacol.Ther., 24:207.
Wisse, E. and De Leeuw, A.M., 1984, Structural elements determining transport and exchange processes in the liver, in: “Microspheres and Drug Therapy, Pharmaceutical, Immunological and Medical Aspects”, S.S. Davis, L. Ilium, J.G. McVie and E. Tomlinson, eds., Elsevier, Amsterdam.
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Davis, S.S., Illum, L. (1994). Particulate Systems for Site Specific Drug Delivery. In: Gregoriadis, G., McCormack, B., Poste, G. (eds) Targeting of Drugs 4. NATO ASI Series, vol 273. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1207-7_17
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DOI: https://doi.org/10.1007/978-1-4899-1207-7_17
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