The Analysis of Muscle Relaxants by Mass Spectrometric Methods

  • Diane Rindgen
  • Paul Vouros
Part of the Modern Analytical Chemistry book series (MOAC)


The introduction of curare in 1942 (1) generated a great interest in the chemistry and pharmacology of a class of compounds known as neuromuscular blocking agents. Curare, a generic term for several South American arrow poisons, has enjoyed a long and romantic history (2). It has been used for many years by the Indians living in the regions surrounding the Amazon and Orinoco Rivers for killing wild animals for food. Only tribal witch doctors possessed the knowledge of the preparation of curare. Following the discovery of the American continent, early explorers became interested in this compound and brought samples of the native preparations to Europe for evaluation.


Muscle Relaxant Chemical Ionization Fast Atom Bombardment Neuromuscular Blocking Agent Pancuronium Bromide 
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Copyright information

© Springer Science+Business Media New York 1992

Authors and Affiliations

  • Diane Rindgen
    • 1
  • Paul Vouros
    • 1
  1. 1.Department of Chemistry and The Barnett Institute of Chemical Analysis and Materials ScienceNortheastern UniversityBostonUSA

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