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T Lymphocytes in Autoimmunity and Transplantation

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Immunopharmacology in Autoimmune Diseases and Transplantation

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Abstract

Approximately 80% of circulating lymphocytes are thymus-derived T cells, and these play an essential role in the regulation of humoral and cellular immune responses. The antigen recognition structure of T cells is the T-cell receptor (TCR). The majority of T cells express a TCR that consists of two disulfide-linked chains, the α and the β chain, which have two extracellular domains, one variable and the other constant, with a joining segment between. These TCRα/β-positive cells recognize antigen that is processed and expressed in the context of major histocompatibility complex (MHC) gene products on the membrane of accessory cells (Zinkernagel and Doherty, 1974). A small proportion of cells express γ and δ chains (Triebel and Hercend, 1989) instead of α and β chains. The function of the γδ TCR, and the identity of its ligand, is as yet unclear.

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Authors and Affiliations

  1. Institute of Immunology and Rheumatology, The National Hospital, N-0172, Oslo 1, Norway

    Jens Kjeldsen-Kragh, Alison Quayle & Catherine Kalvenes

  2. Oslo Sanitetsforening Rheumatism Hospital, N-0172, Oslo 1, Norway

    Øystein Førre

Authors
  1. Jens Kjeldsen-Kragh
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  2. Alison Quayle
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  3. Catherine Kalvenes
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  4. Øystein Førre
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Editor information

Editors and Affiliations

  1. Department of Clinical Pharmacology, The National Hospital, University of Oslo, N-0027, Oslo 1, Norway

    Hans Erik Rugstad

  2. Institute of Clinical Biochemistry, The National Hospital, University of Oslo, 0027, Oslo 1, Norway

    Liv Endresen

  3. Oslo Sanitetsforening Rheumatism Hospital, N-0172, Oslo 1, Norway

    Øystein Førre

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© 1992 Springer Science+Business Media New York

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Kjeldsen-Kragh, J., Quayle, A., Kalvenes, C., Førre, Ø. (1992). T Lymphocytes in Autoimmunity and Transplantation. In: Rugstad, H.E., Endresen, L., Førre, Ø. (eds) Immunopharmacology in Autoimmune Diseases and Transplantation. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1167-4_4

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  • DOI: https://doi.org/10.1007/978-1-4899-1167-4_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1169-8

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