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Oncogenic Transformation of T Cells by Herpesvirus saimiri

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DNA Tumor Viruses

Part of the book series: Infectious Agents and Pathogenesis ((IAPA))

Abstract

Herpesvirus saimiri (HVS) is a ubiquitous agent of squirrel monkeys (Saimiri sciureus); this virus can be reproducibly isolated from the peripheral blood of apparently healthy animals.(1) The most intriguing feature of HVS is its ability to induce acute T-cell lymphomas or lymphoid leukemias. These experimental malignancies develop within a few months after inoculation of the virus into New World monkeys and New Zealand white rabbits.(2–4) Most T lymphocytes transformed in vivo or in vitro by HVS are CD8 positive,(5–9) although some CD4 cell lines have been reported,(9) suggesting that HVS encodes genes responsible for the preferential and efficient immortalization of CD8 T cells.

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Medveczky, P.G. (1995). Oncogenic Transformation of T Cells by Herpesvirus saimiri . In: Barbanti-Brodano, G., Bendinelli, M., Friedman, H. (eds) DNA Tumor Viruses. Infectious Agents and Pathogenesis. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1100-1_13

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