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General Principles of Biological Intervention Following Trauma

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Traumatic Stress

Part of the book series: Springer Series on Stress and Coping ((SSSO))

Abstract

This chapter presents our view of state of the art biological principles for the evaluation and treatment of traumatic stress disorders. The lion’s share of the biological literature on traumatic stress deals with patients suffering from chronic posttraumatic stress disorder (PTSD) (APA, 1987, 1994). There are a range of mental health problems that may follow traumatic events, and it is not clear that each problem shares the same biological characteristics. Therefore, these recommendations may not be generalizable to all patients dealing with the aftermath of a traumatic event.

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References

  • American Psychiatric Association. (1987). Diagnostic and statistical manual of mental disorders (3rd ed., revised). Washington, DC: Author.

    Google Scholar 

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders ( 4th ed. ). Washington, DC: Author.

    Google Scholar 

  • Beasley, C. M., Masica, D. N., Heiligenstein, J. H., Wheadon, D. E., and Zerbe, R. L. (1993). Possible monoamine oxidase inhibitor—serotonin uptake inhibitor interactions: Fluoxetine clinical data and preclinical findings. journal of Clinical Psychopharmacology, 13, 312–320.

    Article  PubMed  Google Scholar 

  • Blake, D. D., Weathers, F. W., Nagy, L. M., Kaloupek, D. G., Klauminzer, G., Charney, D. S., and Keane, T. M. (1990). A clinician rating scale for assessing current and lifetime PTSD: The CAPS-1. The Behavior Therapist, 9, 187–188.

    Google Scholar 

  • Blanchard, E. B., Gerardi, R. J., Kolb, L. C., and Barlow, D. H. (1986). The utility of the Anxiety Disorders Interview Schedule (ADIS) in the diagnosis of post-traumatic stress disorder (PTSD) in Vietnam veterans. Behaviour Research and Therapy, 24, 577–580.

    Article  PubMed  Google Scholar 

  • Blanchard, E. B., Kolb, L. C., Gerardi, R. J., Ryan, P., and Pallmeyer, T. P. (1986). Cardiac response to relevant stimuli as an adjunctive tool for diagnosing post-traumatic stress disorder in Vietnam veterans. Behavior Therapy, 17, 592–606.

    Article  Google Scholar 

  • Brophy, M. H. (1991). Cyproheptadine for combat nightmares in post-traumatic stress disorder and dream anxiety disorder. Military Medicine, 156, 100–101.

    PubMed  Google Scholar 

  • Burgess, A. W., and Holmstrom, L. L. (1979). Adaptive strategies and recovery from rape. American Journal of Psychiatry, 136, 1278–1282.

    PubMed  Google Scholar 

  • Carroll, B. J., Feinberg, M., Greden, J. F., Tarika, J., Albala, A. A., Haskett, R. F., James, N. M., Kronfol, Z., Lohr, N., Steiner, M., de Vigne, J. P., and Young, E. (1981). A specific laboratory test for the diagnosis of melancholia. Archives of General Psychiatry, 38, 15–22.

    Article  PubMed  Google Scholar 

  • Da Costa, J. M. (1871). On irritable heart: A clinical study of a form of functional cardiac disorder and its consequences. American Journal of Medical Science, 61, 17–52.

    Google Scholar 

  • Davidson, J. R. T., Kudler, H. S., Saunders, W. B., Erickson, L., Smith, R. D., Stein, R. M., Lipper, S., Hammett, E. B., Mahorney, S. L., and Cavenar, J. O. (1993). Predicting response to amitriptyline in post-traumatic stress disorder. American Journal of Psychiatry, 150, 1024–1029.

    PubMed  Google Scholar 

  • Davidson, J. R. T., Roth, S., and Newman, E. (1991). Treatment of post-traumatic stress disorder with fluoxetine. Journal of Traumatic Stress, 4, 419–423.

    Article  Google Scholar 

  • Davidson, J. R. T., Smith, R. D., and Kudler, H. S. (1989). Familial psychiatric illness in chronic Post-traumatic Stress Disorder. Comprehensive Psychiatry, 30, 1–7.

    Article  Google Scholar 

  • Derogatis, L. R. (1983). The SCL-90-R: Administration, scoring and procedures manual II. Baltimore: Clinical Psychometric Research.

    Google Scholar 

  • Dingemanse, J. (1993). An update of recent moclobemide interaction data. International Clinical Psychopharmacology, 7, 167–180.

    Article  PubMed  Google Scholar 

  • Dista Products Company (1993). Fluoxetine (Prozac) package insert. Indianapolis: Dista Division of Eli Lilly and Company.

    Google Scholar 

  • Elphick, M. (1989). Clinical issues in the use of carbamazepine in psychiatry: A review. Psychological Medicine, 19, 591–604.

    Article  PubMed  Google Scholar 

  • Erichsen, J. E. (1882). On concussion of the spine: Nervous shock and other obscure injuries of the nervous system in their clinical and medico-legal aspects. London: Longmans, Green and Company.

    Google Scholar 

  • Famularo, R., Kinscherff, R., and Fenton, T. (1988). Propranolol treatment for childhood post-traumatic stress disorder, acute type. American Journal of Diseases of Children, 142, 1244–1247.

    PubMed  Google Scholar 

  • Feighner, J. P., Boyer, W. F., Tyler, D. L., and Neborsky, R. J. (1990). Adverse consequences of fluoxetine-MAOI combination therapy. Journal of Clinical Psychiatry, 51, 222–225.

    PubMed  Google Scholar 

  • Friedman, M. J. (1988). Towards rational pharmacotherapy for post-traumatic stress disorder: An interim report. American Journal of Psychiatry, 145, 281–285.

    PubMed  Google Scholar 

  • Friedman, M. J., Southwick, S. M., and Charney, D. S. (1993). Pharmacotherapy for recently evacuated military casualties. Military Medicine, 158, 493–497.

    PubMed  Google Scholar 

  • Freud, S. (1955a). Beyond the pleasure principle. In J. Strachey (Ed.), Standard edition 18 (pp. 164 ). London: Hogarth Press. Original work published 1920.

    Google Scholar 

  • Freud, S. (1955b). Memorandum on the electrical treatment of war neurotics. In J. Strachey (Ed.), Standard edition (pp. 211–215 ). London: Hogarth Press. Original work published 1920.

    Google Scholar 

  • Gillette, G. M., and Robertson, K. R. (1989). TSH response to TRH in depressed women as related to severity of childhood incestuous abuse. Presented at the 142nd annual meeting of the American Psychiatric Association, San Francisco.

    Google Scholar 

  • Gold, M. S., Pottash, A. C., Sweeny, D. R., and Kleber, H. D. (1980). Opiate withdrawal using clonidine: A safe, effective, and rapid nonopiate treatment. Journal of the American Medical Association, 243, 343–346.

    Article  PubMed  Google Scholar 

  • Grinker, R. R., and Spiegel, J. P. (1945). Men under stress. New York: McGraw-Hill.

    Book  Google Scholar 

  • Gunderson, J. G., and Sabo, A. N. (1993). The phenomenological and conceptual interface between borderline personality disorder and PTSD. American Journal of Psychiatry, 150, 19–27.

    PubMed  Google Scholar 

  • Hamilton, M. (1959). The assessment of anxiety states by rating. British Journal of Medical Psychology, 32, 50–55.

    Article  PubMed  Google Scholar 

  • Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery and Psychiatry, 23, 56–62.

    Article  Google Scholar 

  • Harsch, H. H. (1986). Cyproheptadine for recurrent nightmares. American Journal of Psychiatry, 143, 1491–1492.

    PubMed  Google Scholar 

  • Herman, J. L. (1992). Trauma and recovery. New York: Basic Books.

    Google Scholar 

  • Horowitz, M. J., Wilner, N., and Alvarez, W. (1979). Impact of event scale: A measure of subjective distress. Psychosomatic Medicine, 41, 207–218.

    Google Scholar 

  • Jelinek, J. M., and Williams, T. (1987). Post-traumatic stress disorder and substance abuse: Treatment problems, strategies and recommendations. In T. Williams (Ed.), Post-traumatic stress disorders: A handbook for clinicians (pp. 103–117 ). Cincinnati: Disabled American Veterans.

    Google Scholar 

  • Kardiner, A. (1941). The traumatic neuroses of war. New York: Paul Hoeber.

    Book  Google Scholar 

  • Keane, T. M., Caddell, J. M., and Taylor, K. T. (1988). Mississippi scale for combat-related post-traumatic stress disorder: Three studies in reliability and validity. Journal of Consulting and Clinical Psychology, 56, 85–90.

    Article  PubMed  Google Scholar 

  • Keck, P. E., McElroy, S. L., and Friedman, L. M. (1992). Valproate and carbamazepine in the treatment of panic and post-traumatic stress disorders, withdrawal states, and behavioral dyscontrol syndromes. Journal of Clinical Psychopharmacology, 12 (supplement), 36S - 41S.

    Article  PubMed  Google Scholar 

  • Kilpatrick, D. G., Veronen, L. J., and Resick, P. A. (1979). The aftermath of rape: Recent empirical findings. American Journal of Orthopsychiatry, 49, 658–669.

    Article  PubMed  Google Scholar 

  • Kinzie, J. D., and Leung, P. K. (1989). Clonidine in Cambodian patients with posttraumatic stress disorder. Journal of Nervous and Mental Disease, 177, 546–550.

    Article  PubMed  Google Scholar 

  • Kolb, L. C. (1987). A neuropsychological hypothesis explaining post-traumatic stress disorders. American Journal of Psychiatry, 144, 989–995.

    PubMed  Google Scholar 

  • Kolb, L. C., Burns, B. C., and Griffiths, S. (1984). Propranolol and clonidine in the treatment of post-traumatic stress disorders. In B. A. van der Kolk (Ed.), Posttraumatic stress disorder: Psychological and biological sequelae (pp. 97–107 ). Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Kosten, T. R., Frank, J. B., Dan, E., and Giller, E. L. (1990). Treating post-traumatic stress disorder with phenelzine or imipramine. In E. L. Giller (Ed.), Biological assessment and treatment of post-traumatic stress disorder (pp. 185–202 ). Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Kudler, H. S. (1993). Borderline personality disorder and PTSD [letter]. American Journal of Psychiatry, 150, 1906–1907.

    PubMed  Google Scholar 

  • Kudler, H. S., Davidson, J. R. T., Meador, K., Lipper, S., and Ely, T. (1987). The DST and post-traumatic stress disorder. American Journal of Psychiatry, 144, 1068–1071.

    PubMed  Google Scholar 

  • Kudler, H. S., Davidson, J. R. T., Stein, R. M., and Erickson, L. (1989). Measuring results of treatment of PTSD [letter]. American Journal of Psychiatry, 146, 1645–1646.

    PubMed  Google Scholar 

  • Lipper, S., Davidson, J. R. T., Grady, T., Edinger, J. D., Hammett, E. B., Mahorney, S. L., and Cavenar, J. O. (1986). Preliminary study of carbamazepine in post-traumatic stress disorder. Psychosomatics, 27, 849–854.

    Article  PubMed  Google Scholar 

  • Lydiard, B., Roy-Byrne, P., and Ballenger, J. C. (1988). Recent advances in the psychopharmacological treatment of anxiety disorders. Hospital and Community Psychiatry, 39, 1157–1165.

    PubMed  Google Scholar 

  • Marmar, C. R., Foy, D., Kagan, B., and Pynoos, R. S. (1993). An integrated approach for treating post-traumatic stress. Review of Psychiatry, 12, 239–272.

    Google Scholar 

  • Mason, J. W., Giller, E. L., Kosten, T. R., and Harkness, L. (1988). Elevation of urinary norepinephrine/cortisol ration in post-traumatic stress disorder. Journal of Nervous and Mental Disease, 176, 498–502.

    Article  PubMed  Google Scholar 

  • Metz, A., and Shader, R. I. (1990). Adverse interactions encountered when using trazodone to treat insomnia associated with fluoxetine. International Clinical Psychopharmacology, 5, 191–194.

    Article  PubMed  Google Scholar 

  • Mitchell, S. W. (1877). Fat and blood and how to make them. Philadelphia: J. B. Lippincott and Co.

    Google Scholar 

  • Mott, F. W. (1919). War neuroses and shell shock. London: Oxford Medical Publications.

    Google Scholar 

  • Nagy, L. M., Morgan, C. A., Southwick, S. M., and Charney, D. S. (1993). Open prospective trial of fluoxetine for post-traumatic stress disorder. Journal of Clinical Psychopharmacology, 13, 107–113.

    Article  PubMed  Google Scholar 

  • Nemeroff, C. B. (1991). Augmentation regimens for depression. Journal of Clinical Psychiatry, 52, (Supplement), 21–27.

    PubMed  Google Scholar 

  • Ornitz, E. M., and Pynoos, R. S. (1989). Startle modulation in children with post-traumatic stress disorder. American Journal of Psychiatry, 146, 866–870.

    PubMed  Google Scholar 

  • Pitman, R. K. (1989). Post-traumatic stress disorder, hormones, and memory [editorial]. Biological Psychiatry, 26, 221–223.

    Article  PubMed  Google Scholar 

  • Pitman, R. K., Orr, S. P., Forgue, D. F., Altman, B., de Jong, J. B., and Herz, L. R. (1990). Psychophysiologic responses to combat imagery of Vietnam veterans with posttraumatic stress disorder versus other anxiety disorders. Journal of Abnormal Psychology, 99, 49–54.

    Article  PubMed  Google Scholar 

  • Rainey, J. M., Aleem, A., Ortiz, A., Yergani, V., Pohl, R., and Berchou, R. (1987). A laboratory procedure for the induction of flashbacks. American Journal of Psychiatry, 144, 1317–1419.

    PubMed  Google Scholar 

  • Ross, R. G., Ball, W. A., Sullivan, K. A., and Caroff, S. N. (1989). Sleep disturbance as the hallmark of post-traumatic stress disorder. American Journal of Psychiatry, 146, 697–707.

    PubMed  Google Scholar 

  • Sargant, W. W., and Slater, E. (1972). An introduction to physical methods of treatment in psychiatry. New York: Science House.

    Google Scholar 

  • Solomon, S. D., Gerrity, E. T., and Muff, A. M. (1992). Efficacy of treatments for posttraumatic stress disorder: An empirical review. Journal of theAmericanMedicalAssociation, 268, 633–638.

    Google Scholar 

  • Solomon, Z., and Benbenishty, R. (1989). The role of proximity, immediacy, and expectancy in frontline treatment of combat stress reaction among Israelis in the Lebanon war. American Journal of Psychiatry, 143, 613–617.

    Google Scholar 

  • Southwick, S. M., Krystal, J. H., Morgan, C. A., Johnson, D., Nagy, L. M., Nicolaou, A., Heninger, G. R., and Charney, D. S. (1993). Abnormal noradrenergic function in post-traumatic stress disorder. Archives of General Psychiatry, 50, 266–274.

    Article  PubMed  Google Scholar 

  • Spitzer, R. L., Williams, J. B. W., and Gibbon, M. (1987). Structured clinical interview forDSM-III-R (SCID). New York: Biometrics Research Department, New York State Psychiatric Institute.

    Google Scholar 

  • Sternbach, H. (1988). Danger of MAOI therapy after fluoxetine withdrawal. Lancet, 2, 850–851.

    Article  PubMed  Google Scholar 

  • Stokes, J. (1990). Psychopharmacotherapy in a theater of operations. Presented at Veterans Affairs/Department of Defense Joint Contingency Planning Meeting, Fort Benjamin Harrison, Indianapolis, IN, December 17–21, 1990.

    Google Scholar 

  • Turchan, S. J., Holmes, V. F., and Wasserman, C. S. (1992). Do tricyclic antidepressants have a protective effect in post-traumatic stress disorder? New York Journal of Medicine, 92, 400–402.

    Google Scholar 

  • Tyrer, P. (1983). The place of tranquilizers in the management of stress. Journal of Psychosomatic Research, 27, 385–390.

    Article  PubMed  Google Scholar 

  • Kolk, B. A. (1983). Psychopharmacological issues in post-traumatic stress disorder. Hospital and Community Psychiatry, 34, 683–691.

    PubMed  Google Scholar 

  • Kolk, B., Greenberg, M., Boyd, H., and Krystal, J. H. (1985). Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of posttraumatic stress. Biological Psychiatry, 20, 314–325.

    Article  PubMed  Google Scholar 

  • World Health Organization. (1992). The ICD-10 Classification of Mental and Behavioural Disorders: Clinical Descriptions and Diagnostic Guidelines. Geneva: Author.

    Google Scholar 

  • Yehuda, R., Southwick, S. M., Krystal, J. H., Bremner, J. D., Charney, D. S., and Mason, J. W. (1993). Enhanced suppression of cortisol following dexamethasone administration in post-traumatic stress disorder. American Journal of Psychiatry, 150, 83–86.

    PubMed  Google Scholar 

  • Yost, J. F. (1987). The psychopharmacologic management of post-traumatic stress disorder (PTSD) in Vietnam veterans and in civilian situations. In T. Williams (Ed.), Post-traumatic stress disorders: A handbook for clinicians (pp. 93–101 ). Cincinnati: Disabled American Veterans.

    Google Scholar 

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Author information

Authors and Affiliations

  1. Psychiatry Service, Durham VA Medical Center, Durham, North Carolina, 27705, USA

    Harold Kudler

  2. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina, 27705, USA

    Harold Kudler & Jonathan R. T. Davidson

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  1. Harold Kudler
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  2. Jonathan R. T. Davidson
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Editor information

Editors and Affiliations

  1. National Crime Victims Research and Treatment Center, Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, 29425, Charleston, South Carolina, USA

    John R. Freedy

  2. Applied Psychology Center, Department of Psychology, Kent State University, 44242, Kent, Ohio, USA

    Stevan E. Hobfoll

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Kudler, H., Davidson, J.R.T. (1995). General Principles of Biological Intervention Following Trauma. In: Freedy, J.R., Hobfoll, S.E. (eds) Traumatic Stress. Springer Series on Stress and Coping. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1076-9_4

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  • DOI: https://doi.org/10.1007/978-1-4899-1076-9_4

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1078-3

  • Online ISBN: 978-1-4899-1076-9

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