Molecular Regulation of Blood-Brain Barrier GLUT1 Glucose Transporter
The transport of glucose from the circulation to brain intracellular space involves transport through two membranes in series: the brain capillary endothelial cell, which constitutes the blood-brain barrier (BBB) in vivo, and the brain cell membrane, comprised of neuronal or glial plasma membrane. Owing to the vastly greater surface area of brain cell membranes, relative to the BBB surface area, the rate-limiting transport step of these two membranes in series is at the BBB (Lund-Andersen, 1979). Therefore, modulation of the BBB glucose transporter activity may be an important control point in the overall regulation of cerebral glucose metabolism.
KeywordsUrea Carboxyl Electrophoresis Pyruvate Polyacrylamide
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- Dwyer, K.J., and Pardridge, W.M., 1994, Novel cis-element/trans-acting protein interaction with the 3′untranslated region of GLUT1 glucose transporter mRNA, FASEB J. 8:A374.Google Scholar
- Flier, J.S., Mueckler, M., McCall, A.L., and Lodish, H.F., Distribution of glucose transporter messenger RNA transcripts in tissues of rat and man, J. Clin. Invest. 79:657–661.Google Scholar
- Pardridge, W.M., 1991, “Peptide Drug Delivery to the Brain,” Raven Press, N.Y.Google Scholar
- Pardridge, W.M., and Boado, R.J., 1993, Molecular cloning and regulation of gene expression of blood-brain barrier glucose transporter, in: “The Blood-Brain Barrier: Cellular and Molecular Biology,” W.M. Pardridge, ed., Raven Press, N.Y.Google Scholar