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Capillary Permeability in Central and Peripheral Nerve Tissue in Streptozotocin Diabetes in the Anaesthetised Rat

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New Concepts of a Blood—Brain Barrier

Abstract

In diabetes mellitus of long duration almost all capillary regions are severely affected by microangiopathy including peripheral nerves and the retina of the eye, yet there is little damage to brain capillaries. The experiments we report here were aimed at studying in streptozotocin treated rats potential functional changes in the capillaries of the brain after a long period in untreated diabetes. In co-operation with Professor Sue Lightman of the Institute of Ophthalmology, Moorfields Eye Hospital, University of London, we carried out a study lasting over 14 months after streptozotocin administration.

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References

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© 1995 Springer Science+Business Media New York

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Pinter, G.G., Bradbury, M.W.B. (1995). Capillary Permeability in Central and Peripheral Nerve Tissue in Streptozotocin Diabetes in the Anaesthetised Rat. In: Greenwood, J., Begley, D.J., Segal, M.B. (eds) New Concepts of a Blood—Brain Barrier. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1054-7_7

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  • DOI: https://doi.org/10.1007/978-1-4899-1054-7_7

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1056-1

  • Online ISBN: 978-1-4899-1054-7

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