Abstract
In diabetes mellitus of long duration almost all capillary regions are severely affected by microangiopathy including peripheral nerves and the retina of the eye, yet there is little damage to brain capillaries. The experiments we report here were aimed at studying in streptozotocin treated rats potential functional changes in the capillaries of the brain after a long period in untreated diabetes. In co-operation with Professor Sue Lightman of the Institute of Ophthalmology, Moorfields Eye Hospital, University of London, we carried out a study lasting over 14 months after streptozotocin administration.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
M.W.B. Bradbury, S.L. Lightman, L. Yuen and G.G. Pinter, Permeability of blood-brain and blood-nerve barriers in experimental diabetes mellitus in the anaesthetized rat, Experimental Physiology 76:887 (1991).
S. Lightman, G. Pinter, L. Yuen and M. Bradbury, Permeability changes at blood-retinal barrier in diabetes and effect of aldose reductase inhibition, Am. J. Physiol 259: (Regulatory Integrative Comp. Physiol. 28) R601 (1990).
G.G. Pinter, S.L. Lightman, P.D. Wilson, L. Yuen and M.W.B. Bradbury, Microvascular permeability in kidney, heart and skeletal muscle in experimental diabetes in the anaesthetized rat, Experimental Physiology 76:899 (1991).
G. Lundborg, Ischaemic nerve injury, Scand J. Plastic and Reconstr. Surg. Suppl. No.6 (1970).
K. R. Popper, “Conjectures and Refutations: The Growth of Scientific Knowledge,” Routledge & Kegan Paul, London (1963).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1995 Springer Science+Business Media New York
About this chapter
Cite this chapter
Pinter, G.G., Bradbury, M.W.B. (1995). Capillary Permeability in Central and Peripheral Nerve Tissue in Streptozotocin Diabetes in the Anaesthetised Rat. In: Greenwood, J., Begley, D.J., Segal, M.B. (eds) New Concepts of a Blood—Brain Barrier. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1054-7_7
Download citation
DOI: https://doi.org/10.1007/978-1-4899-1054-7_7
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4899-1056-1
Online ISBN: 978-1-4899-1054-7
eBook Packages: Springer Book Archive