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New Concepts of a Blood—Brain Barrier pp 147–157Cite as

Autacoids as Mediators of Vasogenic Brain Oedema

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Abstract

Under several pathological conditions such as trauma, incomplete ischemia, reperfusion after complete ischemia, tumor, and allergic or inflammatory diseases an opening of the blood-brain barrier (BBB) may occur. The extravasation inducing vasogenic oedema is obviously induced by the release of several autacoids as will be discussed in an updated review of items published previously.1–3 The mainly discussed mediators are histamine, bradykinin, arachidonic acid, free radicals, leukotrienes, and serotonin. Five criteria will be discussed for some favoured mediator candidates: 1) the effect on BBB permeability, 2) the vasomotor action which may affect driving force for transmural bulk flow, 3) the influence on oedema formation, 4) the actual concentration of the mediator in the tissue or in the interstitial space under pathological conditions and 5) the therapeutic results after treatment with specific inhibitors or antagonists.

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Author information

Authors and Affiliations

  1. Department of Physiology, Univ. Munich, Germany

    M. Wahl, L. Schilling, A. Unterberg & A. Baethmann

  2. Department of Neurosurgery, Free Univ. Berlin, Germany

    A. Unterberg

  3. Institute of Surgical Research, Univ. Munich, Germany

    A. Baethmann

Authors
  1. M. Wahl
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  2. L. Schilling
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  3. A. Unterberg
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  4. A. Baethmann
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Editor information

Editors and Affiliations

  1. Institute of Ophthalmology, University College London, London, England

    John Greenwood

  2. King’s College, University of London, London, England

    David J. Begley

  3. United Medical and Dental Schools, St. Thomas’ Hospital, London, England

    Malcolm B. Segal

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© 1995 Springer Science+Business Media New York

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Wahl, M., Schilling, L., Unterberg, A., Baethmann, A. (1995). Autacoids as Mediators of Vasogenic Brain Oedema. In: Greenwood, J., Begley, D.J., Segal, M.B. (eds) New Concepts of a Blood—Brain Barrier. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1054-7_15

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  • DOI: https://doi.org/10.1007/978-1-4899-1054-7_15

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-1056-1

  • Online ISBN: 978-1-4899-1054-7

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