The Dependency of Influx Across the Blood-Brain Barrier on Blood Flow and the Apparent Flow-Independence of Glucose Influx During Stress
The major functions of the blood circulating through microvascular beds are to: 1) delivery nutrients, blood-borne messengers, and immunoactive materials to the surrounding cells and 2) remove locally produced metabolites, hormones, toxic substances, and heat from the tissue. Useful changes in blood flow through local microvascular networks would be expected to be linked to alterations in one or more of these delivery and/or removal needs (luxury perfusion — often observed following severe ischemia or stroke — is a condition in which blood flow apparently greatly exceeds tissue need and is an example of a seemingly useless or “futile” change in blood flow).
KeywordsPermeability Catheter Convection Ischemia Albumin
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