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Activation of Peritoneal Macrophages by Acetylcholinesterase is Independent of Catalytic Activity

  • A. Klegeris
  • T. C. Budd
  • S. A. Greenfield

Abstract

To date the non-cholinergic effects of acetylcholinesterase (AChE) in the central nervous system have been associated with its action on neuronal cells. Two distinct modes of non-classical activity of AChE have been suggested: first, that AChE is a neuromodulatory agent modifying neuronal activity (Greenfield, 1991); secondly, that AChE is playing the role of a cell adhesion molecule during the development and differentiation of the central nervous system (Layer et al., 1993). Although these hypotheses imply involvement of different cellular mechanisms, a common assumption for both is an interaction between AChE and the neuronal cell membrane in a fashion that is currently unknown.

Keywords

AChE Activation Distinct Mode Sugar Binding Brain Macrophage Neuronal Cell Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Greenfield, S.A. (1991) Cell Mol. Neurobiol. 11:55–77.PubMedCrossRefGoogle Scholar
  2. Klegeris, A., Budd, T.C., & Greenfield, S.A. (1994) Cell. Mol. Neurobiol. 14:89–98.PubMedCrossRefGoogle Scholar
  3. Layer, P.G., Weikert, T., & Alber, R. (1993) Cell Tissue Res. 273:219–226.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • A. Klegeris
    • 1
  • T. C. Budd
    • 1
  • S. A. Greenfield
    • 1
  1. 1.University Department of PharmacologyOxfordEngland, UK

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