Activation of Peritoneal Macrophages by Acetylcholinesterase is Independent of Catalytic Activity

  • A. Klegeris
  • T. C. Budd
  • S. A. Greenfield

Abstract

To date the non-cholinergic effects of acetylcholinesterase (AChE) in the central nervous system have been associated with its action on neuronal cells. Two distinct modes of non-classical activity of AChE have been suggested: first, that AChE is a neuromodulatory agent modifying neuronal activity (Greenfield, 1991); secondly, that AChE is playing the role of a cell adhesion molecule during the development and differentiation of the central nervous system (Layer et al., 1993). Although these hypotheses imply involvement of different cellular mechanisms, a common assumption for both is an interaction between AChE and the neuronal cell membrane in a fashion that is currently unknown.

Keywords

Sugar Mannose Monosaccharide Cholinesterase Acetylcholinesterase 

References

  1. Greenfield, S.A. (1991) Cell Mol. Neurobiol. 11:55–77.PubMedCrossRefGoogle Scholar
  2. Klegeris, A., Budd, T.C., & Greenfield, S.A. (1994) Cell. Mol. Neurobiol. 14:89–98.PubMedCrossRefGoogle Scholar
  3. Layer, P.G., Weikert, T., & Alber, R. (1993) Cell Tissue Res. 273:219–226.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • A. Klegeris
    • 1
  • T. C. Budd
    • 1
  • S. A. Greenfield
    • 1
  1. 1.University Department of PharmacologyOxfordEngland, UK

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