Abstract
Physostigmine (Phy) and pyridostigmine (Pyr) are tertiary and quaternary car-bamates, respectively. They reversibly inhibit acetylcholinesterase. These carbamates have been found to be good prophylactic agents for organophosphorus (OP) intoxication in various animal species. In most of the cases the effectiveness of the carbamates has been established against parenterally administered OP compounds. In the present study the effectiveness of a symptom-free dose (a dose that failed to produce any obvious effects) of Phy and Pyr at varous pretreatment intervals against sarin aerosols in rats is examined.
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© 1995 Springer Science+Business Media New York
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Vijayaraghavan, R., Husain, K., Kumar, P., Pandey, K.S., Das Gupta, S. (1995). Protective Efficacy of Physostigmine and Pyridostigmine at Various Pretreatment Times against Inhaled Sarin in Rats. In: Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P. (eds) Enzymes of the Cholinesterase Family. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1051-6_85
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DOI: https://doi.org/10.1007/978-1-4899-1051-6_85
Publisher Name: Springer, Boston, MA
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Online ISBN: 978-1-4899-1051-6
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