Inactivation of the Catalytic Activities in Human Serum Butyrylcholinesterase by Metal Chelators
Human serum butyrylcholinesterase (BChE) which shows 53% of sequence identity to acetylcholinesterase (AChE) exhibits an arylacylamidase (AAA) and a peptidase activity. Earlier studies in our laboratory have shown that the peptidase activity in BChE was inhibited by metal chelators and metal ions can stimulate the peptidase activity. (Rao and Balasubramanian, 1993). In pursuance of those studies we describe now that metal chelators can inhibit not only the peptidase but also the cholinesterase and AAA activities.