Effect of Physical/Chemical Stressors on the Cholinergic System in Rat
Synaptic transmission is mediated by acetylcholine-neurotransmitter between preganglionic and post ganglionic nerve fibre in the sympathetic pathway and those sites that use this neurotransmitter are called cholinergic. The sites that use norepinephrine as neurotransmitter are called adrenergic. This presentation primarily concerns with cholinergic system. It is comprised of neurotransmitter acetylcholine, its receptors (muscarinic and nicotinic) and enzymes involved for its synthesis - choline acetyltransferase (ChAT) and degradation - acetylcholinesterase (AChE). The level of acetylcholine in the CNS is regulated by its anabolism through ChAT and catabolism through AChE. The neurotransmitters play an important role for human beings to adjust and adapt to any changes in their environment. Alterations in the central neurotransmitter system due to physical exercise and/or chemical Stressors have not received much attention. Of the few studies that have specifically examined biochemical markers of the brain cholinergic system, the two most frequently measured indices have been the biosynthetic enzyme of acetylcholine (ACh), choline acetyltransferase (ChAT), and the degradative enzyme, acetylcholinesterase (AChE).
KeywordsRespiration Immobilization Norepinephrine Choline Acetylcholine
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