Abstract
Acetylcholinesterase (AChE) which is concentrated at vertebrate neuromuscular junctions between the presynaptic release sites and the postsynaptic receptors (AChR), hydrolyzes acetylcholine (ACh) and thereby assists in termination of neuromuscular transmission. Knowledge of junctional AChE and AChR concentrations is crucial for understanding transmission at this synapse. However, although AChR density has been measured in endplates of several species, and shows little variability (Fertuck and Salpeter, 1976; Matthews-Bellinger and Salpeter, 1978; Land et al., 1980), AChE density has been determined only in mouse endplates (Rogers et al., 1969; Salpeter et al., 1972, 1978).
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Anglister, L., Stiles, J.R., Haesaert, B., Eichler, J., Salpeter, M.M. (1995). Acetylcholinesterase at Neuromuscular Junctions. In: Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P. (eds) Enzymes of the Cholinesterase Family. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1051-6_55
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