Acetylcholinesterase at Neuromuscular Junctions

Density, Catalytic Turnover, and Molecular Forms with Modeling and Physiological Implications
  • L. Anglister
  • J. R. Stiles
  • B. Haesaert
  • J. Eichler
  • M. M. Salpeter

Abstract

Acetylcholinesterase (AChE) which is concentrated at vertebrate neuromuscular junctions between the presynaptic release sites and the postsynaptic receptors (AChR), hydrolyzes acetylcholine (ACh) and thereby assists in termination of neuromuscular transmission. Knowledge of junctional AChE and AChR concentrations is crucial for understanding transmission at this synapse. However, although AChR density has been measured in endplates of several species, and shows little variability (Fertuck and Salpeter, 1976; Matthews-Bellinger and Salpeter, 1978; Land et al., 1980), AChE density has been determined only in mouse endplates (Rogers et al., 1969; Salpeter et al., 1972, 1978).

Keywords

Hydrolysis Sucrose Acetylcholine Crest Oxime 

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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • L. Anglister
    • 1
  • J. R. Stiles
    • 2
  • B. Haesaert
    • 1
  • J. Eichler
    • 1
  • M. M. Salpeter
    • 2
  1. 1.Department of Anatomy and EmbryologyHebrew University—Hadassah Medical SchoolJerusalemIsrael
  2. 2.Section of Neurobiology and Behavior Division of Biological SciencesCornell UniversityIthacaUSA

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