Abstract
Three genes (ace-1, ace-2, and ace-3) encode acetylcholinesterases (AChEs) in the nematode Caenorhabditis elegans (review in Johnson, 1991). The three enzymes differ in their catalytic properties and are called AChE of class A, B and C respectively. Classes A and B AChEs are major components accounting for at least 95% of the total AChE activity. They are both expressed in the motor system and in particular at the cholinergic excitatory neuromuscular junctions since homozygous double null mutants ace-l-/ace-2- are uncoordinated and hypercontracted.
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References
Anselmet A., Fauquet M., Chatel J.M., Maulet Y., Massoulié J., Vallette F.M. (1994) J Neurochem 62, 2158–2165
Arpagaus M., Richier P., Berge J.B., Toutant J.P (1992) Eur J Biochem 207, 1101–1108
Arpagaus M., Fedon, Cousin X., Chatonnet A., Bergé J.B., Fournier D., Toutant J.R (1994) J Biol. Chem 269, 9957–9965
Bon S., Toutant J.R, Méflah K., Massoulié J. (1988) J Neurochem 51, 786–794
Brenner S. (1988) Nature 334, 528–530
Duval N., Massoulié J., Bon S. (1992) J Cell Biol. 118, 641–653
Fedon Y., Cousin X., Toutant J.R, Thierry-Mieg D., Arpagaus M. (1993) DNA Sequence 3, 347–355
Hall L.M.C., Spierer P. (1986) EMBO J 5, 2949–2954
Jbilo O., L’Hermite Y., Talesa V., Toutant J.R, Chatonnet A. (1994) Eur J Biochem, in press.
Johnson C.D., Duckett J.G., Culotti J.G., Herman R.K., Mennely P.M., Russell R.L. (1981) Genetics 97, 261–279
Johnson C.D. (1991) in Cholinesterases (Massoulié J et al., eds). Pp 136–140. American Chemical Society, Washington, D.C
Herman R.K., Kari C.K. (1985) Cell 40, 509–514
Massoulié J., Pezzementi L., Bon S., Krejci E., Vallette F.M. (1993) Prog Neurobiol 41, 31–91
Rachinsky T.L., Camp S., Li Y., Ekström T.J., Newton M., Taylor P. (1990) Neuron 5, 317–327
Shafferman A., Velan B., Ordentlich A., Kronman C., Grossfeld H., Leitner M., Flashner Y., Cohen S., Barak D., Ariel N. (1992) EMBO J. 11, 3561–3568.
Sussman J.L., Harel M., Frolow R., Oefner C., Goldman A., Toker L., Silman I. (1991) Science 253, 872–879
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Arpagaus, M. et al. (1995). Properties of Class a Acetylcholinesterase, the Enzyme Encoded by ACE-1 in Caenorhabditis elegans. In: Quinn, D.M., Balasubramanian, A.S., Doctor, B.P., Taylor, P. (eds) Enzymes of the Cholinesterase Family. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1051-6_2
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DOI: https://doi.org/10.1007/978-1-4899-1051-6_2
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