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Psychotraumatology pp 171–194Cite as

Biological Approaches to the Diagnosis and Treatment of Post-Traumatic Stress Disorder

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Part of the book series: The Springer Series on Stress and Coping ((SSSO))

Abstract

Biological approaches to the diagnosis and treatment of PTSD are receiving increasing attention from scientists and clinicians. Research findings appear to suggest that patients with PTSD display marked abnormalities in sympathetic nervous system arousal, in hypothalamic-pituitary-adrenocortical function, in the endogenous opioid system, and in the physiology of sleep and dreaming. Such results enable. us to expand our theoretical understanding of PTSD from a purely psychological context to a bio-psycho-social model in which many different factors contribute to the pathology of PTSD.

Reprinted from Journal of Traumatic Stress, Vol. 4, No. 1.

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References

  • Akiskal, H. S. (1983). Diagnosis and classification of affective disorders: New insights from clinical and laboratory approaches. Psychiatr. Dev., 2, 123–160.

    Google Scholar 

  • Archibald, H. C. & Tuddenham, R. D. (1965). Persistent stress reaction after combat: A 20 year follow-up. Arch. Gen. Psychiat., 12, 475–481.

    Article  PubMed  CAS  Google Scholar 

  • Atri, P. B., and Gilliam, J. H. (1990). Letter. Am. J. Psychiat., 146, 128.

    Google Scholar 

  • Beard, G. M. (1869). Neurasthenia or nervous exhaustion. Bost. Med. Surg. J., 3, 3–217.

    Google Scholar 

  • Blake, D. J. (1986). Treatment of acute post-traumatic stress disorder with tricyclic antidepressants. South. Med. J., 79, 201–204.

    Article  PubMed  CAS  Google Scholar 

  • Benedikt, R. A., and Kolb, L. C. (1986). Preliminary findings on chronic pain and post-traumatic stress disorder. Am. J. Psychiat., 143, 908–910.

    PubMed  CAS  Google Scholar 

  • Blanchard, E. G., Kolb, L. C., Pallmeyer, B. A., and Gerardi, R. J. (1982). A psychophysiological study of post-traumatic stress disorder in Vietnam veterans. Psychiat. Quart., 54, 220–229.

    Article  PubMed  CAS  Google Scholar 

  • Boehnlein, J. K., Kinzie, J. D., Ben, R., et al. (1985). One-year follow-up study of post-traumatic stress disorder among survivors of Cambodian concentration camps. Am. J. Psychiat, 142, 956–959.

    PubMed  CAS  Google Scholar 

  • Branchey, L., Davis, W. & Lieber, C. S. (1984). Alcoholism in Vietnam and Korea veterans: A long term follow-up. Alcoholism: Clin. Exp. Res., 8, 572–757.

    Article  CAS  Google Scholar 

  • Brende, J. O. (1982). Electrodermal responses in post-traumatic syndromes. Nerv. Ment. Dis., 170, 352–361.

    Article  CAS  Google Scholar 

  • Burstein, A. (1982). Treatment of post-traumatic stress disorder with imipramine. Psychosomatics, 25, 681–687.

    Article  Google Scholar 

  • Carroll, B. J., Feinberg, M., Greden, J. F., et al. (1981). A specific laboratory test for the diagnosis of melancholia. Arch. Gen. Psychiat., 38, 15–22.

    Article  PubMed  CAS  Google Scholar 

  • Charney, D. S., Woods, S. W., Goodman, W. K., and Heninger, G. K. (1987). Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbineinduced panic attacks. Am. J. Psychiat., 144, 1030–1036.

    PubMed  CAS  Google Scholar 

  • Ciccone, P. E., Mazarek, A., Weisbrot, M., et al. (1990). Letter. Am. J. Psychiat., 146, 812.

    Google Scholar 

  • Cohen, M. E., White, P. D., and Johnson, R. E. (1948). Neurocirculatory asthenia, anxiety neurosis or the effort syndrome. Arch. Int. Med., 81, 260–281.

    Article  CAS  Google Scholar 

  • Cohen, M. E., and White, P. D. (1950). Life situations, emotions and neurocirculatory asthenia (anxiety neurosis, neurasthenia, effort syndrome). Res. Publ. Assoc. Res. Nerv. Ment. Dis., 29, 832–864.

    Google Scholar 

  • DaCosta, J. M. (1871). On irritable heart: A clinical study of a form of functional cardiac disorder and its consequences. Am. J. Med. Sci., 61, 17–52.

    Google Scholar 

  • Davidson, J., Lipper, S., Kilts, C. D., et al. (1985). Platelet MAO activity in posttraumatic stress disorder. Am. J. Psychiat., 142, 1341–1343.

    PubMed  CAS  Google Scholar 

  • Davidson, J., Walker, J. I., and Kilts, C. (1987). A pilot study of phenelzine in the treatment of post-traumatic stress disorder. Brit. J. Psychiat., 150, 252–255.

    Article  PubMed  CAS  Google Scholar 

  • Davidson, J., Kudler, H., Smith, R., et al. ( 1988, May). Amitriptyline treatment of PTSD. Presented at 141st annual meeting of the American Psychiatric Association, Montreal.

    Google Scholar 

  • Dobbs, D., and Wilson, W. P. (1961). Observations on persistence of war neurosis. Dis. Nerv. Sys., 21, 40–46.

    Google Scholar 

  • Dube, S., Jones, D. A., and Bell, J. (1986). Interface of panic and depression: Clinical and sleep EEG correlates. Psychiat. Res., 119, 119–133.

    Article  Google Scholar 

  • Embry, C. K., and Callahan, B. (1988). Effective pharmacotherapy for post-traumatic stress disorder. VA Pract., 5, 57–66.

    Google Scholar 

  • Falcon, S., Ryan, C., Chamberlain, K., and Curtis, G. (1985). Tricyclics: Possible treatment for posttraumatic stress disorder. J. Clin. Psychiat., 46, 385–389.

    CAS  Google Scholar 

  • Famularo, R., Kinscherff, R., and Fenton, T. (1988). Propranolol treatment for childhood posttraumatic stress disorder, acute type: A pilot study. Am. J. Dis. Child., 142, 1244–1247.

    PubMed  CAS  Google Scholar 

  • Feighner, J. P., Aden, G. C., Fabre, L. F., Rickels, K., and Smith, W. T. (1983). Comparison of alprazolam, imipramine and placebo in the treatment of depression./ Am. Med. Assoc., 249, 3057–3064.

    Article  CAS  Google Scholar 

  • Frank, J. B., Kosten, T. R., Dan, E., et al. ( 1988, May). Imipramine and phenelzine treatment of PTSD. Presented at 141st annual meeting of the Am. Psychiat. Assoc., Montreal.

    Google Scholar 

  • Friedman, M. J. (1981). Post-Vietnam syndrome: recognition and management. Psychosomatics, 22, 931–943.

    PubMed  CAS  Google Scholar 

  • Friedman, M. J. (1988). Towards rational pharmacotherapy for post-traumatic stress disorder. Am. J. Psychiat., 145, 281–285.

    PubMed  CAS  Google Scholar 

  • Fryer, M. R., Uy, J., Martinez, J., et al. (1987). CO2 challenge of patients with panic disorder. Am. J. Psychiat., 144, 1080–1082.

    Google Scholar 

  • Gillespie, R. D. (1942). Psychological effects of war on citizen and soldier. New York: Norton.

    Google Scholar 

  • Greenberg, R., Pearlman, C. A., and Gampel, D. (1972). War neuroses and the adaptive function of REM sleep. Brit. J. Med. Psychol., 45, 27–33.

    Article  PubMed  CAS  Google Scholar 

  • Greenstein, R. A., Kitchner, I., and Olsen, K. (1986). Post-traumatic stress disorder, partial complex seizures, and alcoholism. Am. J. Psychiat., 142, 1203.

    Google Scholar 

  • Halbreich, U., Olympia, J., Glogowski, J., et al. (1988). The importance of past psychological trauma and pathophysiologic process as determinants of current biologic abnormalities. Arch. Gen. Psychiat., 45, 293–294.

    Article  PubMed  CAS  Google Scholar 

  • Hartshorne, H. (1863). On heart disease in the army. Am. J. Med. Sci., 47, 89–92.

    Google Scholar 

  • Hauri, P. J., Friedman, M. J., and Ravaris, C. L. (1989). Sleep in patients with spontaneous panic attacks. Sleep, 12, 323–337.

    PubMed  CAS  Google Scholar 

  • Higgitt, A. C., Lader, M. H., and Fonagy, P. (1985). Clinical management of benzodiazepine dependence. Brit. Med. J., 291, 688–690.

    Article  CAS  Google Scholar 

  • Hogben, G. L., and Cornfield, R. B. (1981). Treatment of traumatic war neurosis with phenelzine. Arch. Gen. Psychiat., 38, 440–445.

    Article  PubMed  CAS  Google Scholar 

  • Kardiner, A. (1941). The traumatic neuroses of war. Psychosomatic Medicine Monographs, 11–111.

    Google Scholar 

  • Kardiner, A., and Speigel, H. (1947). The traumatic neuroses of war. New York: Hoeber.

    Google Scholar 

  • Kauffman, C. D., Reist, C., Djenderedjian, A., et al. (1987). Biological markers of affective disorders and posttraumatic stress disorder. A pilot study with desipramine. J. Clin. Psychiat., 48, 366–367.

    CAS  Google Scholar 

  • Keane, T. M., Zimering, R. T., and Caddell, J. M. (1985). A behavioral formulation of post-traumatic stress disorder in Vietnam veterans. Behay. Ther., 8, 9–12.

    Google Scholar 

  • Keane, T. M., Gerardi, R. J., Lyons, J. A., et al. (1988). The interrelationship of substance abuse and posttraumatic stress disorder: Epidemiological and clinical considerations. Rec. Dev. Alcohol., 6, 27–48.

    Article  CAS  Google Scholar 

  • Kitchner, L., and Greenstein, R. (1985). Low dose lithium carbonate in the treatment of posttraumatic stress disorder: Brief communication. Milit. Med., 150, 378–381.

    CAS  Google Scholar 

  • Kolb, L. C. (1985). The place of narcosynthesis in the treatment of chronic and delayed stress reactions of war. In Sonnenberg, S. M., Blank, A. S., and Talbott, J. A. (eds.), The trauma of war stress and recovery in Vietnam veterans, (pp. 211–226 ). Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Kolb, L. C. (1987). A neuropsychological hypothesis explaining post-traumatic stress disorders. Am. J. Psychiat., 144, 989–995.

    PubMed  CAS  Google Scholar 

  • Kolb, L. C., Burris, B. C., Griffiths, S. (1984). Propranolol and clonidine in the treatment of the chronic posttraumatic stress disorders of war. In B. A. van der Kolk, (Ed.), Post-traumatic stress disorder: Psychological and biological sequelae. Washington, DC: American Psychiatric Press.

    Google Scholar 

  • Kosten, T. R., and Krystal, J. (1988). Biological mechanisms in post-traumatic stress disorder: Relevance for substance abuse. Rec. Dev. Alcohol, 6, 49–68.

    Article  CAS  Google Scholar 

  • Kosten, T. R., Mason, J. W., Giller, E. L., et al. (1987). Sustained urinary norepinephrine elevation in post-traumatic stress disorder. Psychoneuroendocrinology, 12, 13–30.

    Article  PubMed  CAS  Google Scholar 

  • Kosten, T. R., Giller, E. L., and Mason, J. W. ( 1988, May). Psychoendocrine assessment of PTSD. Presented at 141st annual meeting, American Psychiatric Association, Montreal.

    Google Scholar 

  • Kramer, M. (1979). Dream disturbance. Psychiat. Ann., 9, 50–60.

    Google Scholar 

  • Kramer, M., and Kinney, L. (1985). Is sleep a marker of vulnerability to delayed posttraumatic stress disorder? Sleep Res., 14, 181.

    Google Scholar 

  • Kramer, M., and Kinney, L. (1988). Sleep patterns in trauma victims with disturbed dreaming. Psychiat. J. Univ. Ottawa, 13, 12–16.

    CAS  Google Scholar 

  • Kramer, M., Kinney, L., and Scharf, M. (1982). Sleep in delayed stress victims. Sleep Res., 11, 113.

    Google Scholar 

  • Kudler, H., Davidson, J., and Meador, K. (1987). The DST and post-traumatic stress disorder. Am. J. Psychiat., 144, 1068–1071.

    PubMed  CAS  Google Scholar 

  • Kupfer, D. J., and Thase, M. E. (1983). The use of the sleep laboratory in the diagnosis of affective disorders. Psychiat. Clin. North Am., 6, 3–25.

    CAS  Google Scholar 

  • Lavie, P., Hefez, A., Halperin, G., et al., (1979). Long-term effects of traumatic war-related events on sleep. Am. J. Psychiat., 136, 175–178.

    PubMed  CAS  Google Scholar 

  • Lerer, B., Ebstein, R., Shestatsky, M., et al. (1987). Cyclic AMP signal transduction in post-traumatic stress disorder. Am. J. Psychiat., 144, 1324–1327.

    PubMed  CAS  Google Scholar 

  • Lerer, B., Bleich, A., and Kotler, M. (1987). Post-traumatic stress disorder in Israeli combat veterans: Effect of phenelzine treatment. Arch. Gen. Psychiat., 44, 976–981.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, T. (1917). Reports upon soldiers returned as cases of disordered action of the heart (DAH) or valvular disease of the heart (VDH). London: His Majesty’s Stationery Office.

    Google Scholar 

  • Lipper, S., Davidson, J. R. T., Grady, T. A., et al. (1986). Preliminary study of carbamazepine in posttraumatic stress disorder. Psychosomatics, 27, 849–854.

    Article  PubMed  CAS  Google Scholar 

  • Malloy, P. F., Fairbank, J. A., and Keane, T. M. (1983). Validation of a multimethod assessment of post-traumatic stress disorders in Vietnam veterans. J. Consult. Clin. Psychol., 51, 488–494.

    Article  PubMed  CAS  Google Scholar 

  • Marshall, J. R. (1975). The treatment of night terrors associated with the post-traumatic syndrome. Am. J. Psychiat., 132, 293–295.

    PubMed  CAS  Google Scholar 

  • Mason, J. W., Giller, E. L., Kosten, T. R., et al. (1985). Elevation of urinary norepinephrinelcortisol ratio in post-traumatic stress disorder, Paper presented at “New Research Program and Abstracts,” 138th annual meeting of the American Psychiatric Association, Washington, DC.

    Google Scholar 

  • Mason, J. W., Giller, E. I., Kosten, T. R., Ostroff, R., and Harkness, L. (1986). Urinary free-cortisol in post-traumatic stress disorder. J. Nerv. Ment. Dis., 174, 145–149.

    Article  PubMed  CAS  Google Scholar 

  • McNamara, J. O., Bonhaus, D. W., Shin, C., Crain, B. J., Gellman, R. L., and Giacchino, J. L. (1985). The kindling model of epilepsy: A critical review. CRC Grit. Rev. Clin. Neurobiol., 1, 341–391.

    CAS  Google Scholar 

  • Mellman, T. A., and Davis, G. C. (1985). Combat-related flashbacks in post-traumatic stress disorder: Phenomenology and similarity to panic attacks. J. Clin. Psychiat., 46, 379382.

    Google Scholar 

  • Milanes, F. S., Mack, C. N., and Dennison, J. (1984). Phenelzine treatment of post-Vietnam stress syndrome. VA Practit., 40–49.

    Google Scholar 

  • Morita, K., Okamoto, M., Seki, K., and Wada, J. A. (1985). Suppression of amygdala-kindled seizures in cats by enhanced GABAergic transmission in the substantia innominata. Exp. Neurol., 89, 225–236.

    Article  PubMed  CAS  Google Scholar 

  • Mueser, K. T., and Butler, R. W. (1987). Auditory hallucinations in combat-related chronic post-traumatic stress disorder. Am. J. Psychiat., 144, 299–302.

    PubMed  CAS  Google Scholar 

  • Noyes, R., Clancy, J., Coryell, W. H., Crowe, R. R., Chaudhry, D. R., and Domingo, D. V. (1985). A withdrawal syndrome after abrupt discontinuation of alprazolam. Am. J. Psychiat., 142, 114–116.

    PubMed  Google Scholar 

  • Perry, B. D., Giller, E. L., and Southwick, S. M. (1987). Altered platelet alpha 2 adrenergic binding sites in post-traumatic stress disorder. Am. J. Psychiat., 144,1511–1512.

    Google Scholar 

  • Mueser, K. T., and Butler, R. W. (1987). Auditory hallucinations in combat-related chronic post-traumatic stress disorder. Am. J. Psychiat., 144, 299–302.

    PubMed  CAS  Google Scholar 

  • Perry, B. D., Southwick, S. M., and Giller, E. L. ( 1988, May). Adrenergic receptor regulation in PTSD. Paper presented at 141st annual meeting of the American Psychiatric Association, Montreal.

    Google Scholar 

  • Perry, S. W., Cella, D. F., Falkenberg, J., et al. (1987). Pain perception in burn patients with stress disorders. J. Pain Sympt. Manag., 2, 29–33.

    Article  CAS  Google Scholar 

  • Pitman, R. K., Orr, S. P., Forgue, D. F., et al. (1987). Psychophysiologic assessment of post-traumatic stress disorder imagery in Vietnam combat veterans. Arch. Gen. Psychiat., 44, 970–975.

    Article  PubMed  CAS  Google Scholar 

  • Pitman, R. K., van der Kolk, B., Orr, S. P., et al. (1990). Naloxone-reversible analgesic response to combat-related stimuli in post-traumatic stress disorder. Arch. Gen. Psychiat., 47, 541–544.

    Article  PubMed  CAS  Google Scholar 

  • Pitts, F. N., Jr., and McClure, J. N., Jr. (1967). Lactate metabolism in anxiety neurosis. N. Eng. J. Med., 277, 1329–1336.

    Article  Google Scholar 

  • Post, R. M., and Kopanda, R. T. (1976). Cocaine, kindling and psychosis. Am. J Psychiat., 133, 627–634.

    CAS  Google Scholar 

  • Price, L. H., Charney, I. D. S., Rubin, A. L., and Heninger, G. R. (1986). Alpha-2 adrenergic receptor function in depression: The cortisol response to yohimbine. Arch. Gen. Psychiat., 43, 849–858.

    Article  PubMed  CAS  Google Scholar 

  • Rainey, J. M., Aleem, A., Ortiz, A., et al. (1987). A laboratory procedure for the induction of flashbacks. Am. J. Psychiat., 144, 1317–1319.

    PubMed  Google Scholar 

  • Rapaport, M. H. (1987). Chronic pain and post-traumatic stress disorder. Am. J. Psychiat., 144, 120.

    PubMed  CAS  Google Scholar 

  • Ravaris, C. L., Friedman, M. J., and Hauri, P. ( 1986, May). A controlled study of alprazolam and propranolol in panic disorder and agoraphobic patients. Paper presented at 139th annual meeting, American Psychiatric Association, Washington, DC.

    Google Scholar 

  • Ross, R. J., Ball, W., and Morrison, A. (1990). Letter. Am. J. Psychiat., 147, 374.

    Google Scholar 

  • Ross, R. J., Ball, W. A., Sullivan, K. A. & Caroff, S. N. (1989). Sleep disturbance as the hallmark of post-traumatic stress disorder. Am. J. Psychiat, 146, 697–707.

    PubMed  CAS  Google Scholar 

  • Sapol, E., and Roffman, R. A. (1969). Marijuana in Vietnam. Journal of the American Pharmaceutical Association, NS9, 615–630.

    Google Scholar 

  • Schlossberg, A., and Benjamin, M. (1978). Sleep patterns in three acute combat fatigue cases. J. Clin. Psychiat., 39, 546–549.

    Google Scholar 

  • Shalev, A. Y., Bleich, A. & Ursano, R. J. (1990). Posttraumatic stress disorder: somatic comorbidity and effort tolerance. Psychosomatics, 31, 197–203.

    Article  PubMed  CAS  Google Scholar 

  • Sheehan, D. V. (1982). Current perspectives in the treatment of panic and phobic disorders. Drug Ther., 7, 179–193.

    Google Scholar 

  • Shen, W. W., and Park, S. (1983). The use of monoamine oxidase inhibitors in the treatment of traumatic war neurosis: Case report. Milit. Med., 148, 430–431.

    CAS  Google Scholar 

  • Solomon, Z., and Mikulincer, M. (1987). Combat stress reaction, post-traumatic stress disorder and somatic complaints among Israeli soldiers. J. Psychosom. Res., 31, 131–137.

    Article  PubMed  CAS  Google Scholar 

  • Stewart, J. R., and Bartucci, R. J. (1986). Post-traumatic stress disorder and partial complex seizures. Am. J. Psychiat., 143, 113–114.

    PubMed  CAS  Google Scholar 

  • Stone, A. (1988). Letter. Am. J. Psychiat., 145, 1485.

    Google Scholar 

  • Suzman, M. M. (1971). The use of beta-adrenergic blockade with propranolol in anxiety syndrome. Postgrad. Med. J., 47, 104–108.

    Google Scholar 

  • Tanna, V. T., Penningroth, R. P., and Woolson, R. F. (1977). Propranolol in the treatment of anxiety neurosis. Comp. Psychiat., 18, 319–326.

    Article  CAS  Google Scholar 

  • Tietz, E. I., Gomaz, F., and Berman, R. F. (1985). Amygdala kindled seizure stage is related to altered benzodiazepine binding site density. Life Sci., 36, 183–190.

    Article  PubMed  CAS  Google Scholar 

  • Tyrer, P. J., and Lader, M. H. (1974). Response to propranolol and diazepam in somatic anxiety. Brit. Med. J., 2, 14–16.

    Article  PubMed  CAS  Google Scholar 

  • Uhde, T. W., Stein, M. B., and Post, R. M. (1988). Lack of efficacy of carbamazepine in the treatment of panic disorder. Am. J. Psychiat., 145, 1104–1109.

    PubMed  CAS  Google Scholar 

  • van der Kolk, B. A. (1983). Psychopharmacological issues in post-traumatic stress disorder. Hosp. Commun. Psychiat., 34, 683–691.

    Google Scholar 

  • van der Kolk, B. A. (1987). The drug treatment of post-traumatic stress disorder. Affect. Dis., 13, 203–213.

    Article  Google Scholar 

  • van der Kolk, B. A., Blitz, R., Burr, W., Sherry, S., and Hartmann, E. (1984). Nightmares and trauma: A comparison of nightmares after combat with lifelong nightmares in veterans. Am. J. Psychiat., 141, 187–190.

    PubMed  Google Scholar 

  • van der Kolk, B. A., Greenberg, M., Boyd, H., and Krystal, J. (1985). Inescapable shock, neurotransmitters, and addiction to trauma: Toward a psychobiology of post-traumatic stress. Biol. Psychiat., 20, 314–325.

    Article  PubMed  Google Scholar 

  • Van Kammen, W., Christiansen, C., Van Kammen, D., et al. (1987). Sleep and the POW experience: 40 years later. Sleep Res., 16, 291.

    Google Scholar 

  • Walker, J. I. (1982). Chemotherapy of traumatic war stress. Milit. Med., 147, 1029–1033.

    CAS  Google Scholar 

  • Wedding, D. (1987). Substance abuse in the Vietnam veteran. AAOHNJ., 35, 74–76.

    CAS  Google Scholar 

  • Wolf, M. E., Alavi, A., and Mosnaim, A. D. (1988). Post-traumatic stress disorder in Vietnam veterans clinical and EEG findings; possible therapeutic effects of carbamazepine. Biol. Psychiat., 23, 642–644.

    Article  PubMed  CAS  Google Scholar 

  • Wood, P. (1941). DaCosta’s syndrome or effort syndrome. Brit. Med. J., 1, 767, 805–845.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Veterans Affairs Medical and Regional Office Center, National Center for PTSD, White River Junction, Vermont, 05009, USA

    Matthew J. Friedman

  2. Dartmouth College Medical School, Hanover, New Hampshire, 03756, USA

    Matthew J. Friedman

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Editors and Affiliations

  1. International Critical Incident Stress Foundation, 21242, Ellicott City, Maryland, USA

    George S. Everly Jr.

  2. Union Memorial Hospital, 21218, Baltimore, Maryland, USA

    George S. Everly Jr.

  3. Department of Psychology, Loyola College, 21210, Baltimore, Maryland, USA

    George S. Everly Jr.

  4. Division of Psychology and Behavioral Medicine, Union Memorial Hospital, 21218, Baltimore, Maryland, USA

    Jeffrey M. Lating

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Friedman, M.J. (1994). Biological Approaches to the Diagnosis and Treatment of Post-Traumatic Stress Disorder. In: Everly, G.S., Lating, J.M. (eds) Psychotraumatology. The Springer Series on Stress and Coping. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-1034-9_11

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