Fatigue pp 323-338 | Cite as

The Significance of Motor Unit Variability in Sustaining Mechanical Output of Muscle

  • A. J. Sargeant
  • D. A. Jones
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 384)

Abstract

Neuromuscular function and fatigue have been studied using a wide variety of preparations. These range from sections of single fibers from which the cell membrane has been removed to whole muscles or groups of muscles acting about a joint in the intact animal. Each type of preparation has its merits and limitations. There is no ideal preparation; rather the question to be answered will determine the most appropriate model in each case and sometimes a combination of approaches will be needed. In particular, it is important to understand how the mechanical output of whole muscle can be sustained to meet the demands of a task and to take into account the organized variability of the constituent motor units.

Keywords

Fatigue Dioxide Covariance NADH Tetrazolium 

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References

  1. Alexander RMcN (1984). Elastic energy stores in running vertebrates. American Zoologist 24, 85–94.Google Scholar
  2. Baumann H, Jaggi M, Soland F, Howald H & Schaub MC (1987). Exercise training induces transitions of myosin isoform subunits within histochemically typed human muscle fibers. Pflügers Archiv 409, 349–360.PubMedCrossRefGoogle Scholar
  3. Beelen A & Sargeant AJ (1991). Effect of fatigue on maximal power output at different contraction velocities in humans. Journal of Applied Physiology 71, 2332–2337.PubMedGoogle Scholar
  4. Beelen A & Sargeant AJ (1993). Effect of prior exercise at different pedal frequencies on maximal power in humans. European Journal of Applied Physiology 66, 102–107.CrossRefGoogle Scholar
  5. Beelen A, Sargeant AJ, Lind A, de Haan A, Kernell D & van Mechelen W (1993). Effect of contraction velocity on the pattern of glycogen depletion in human muscle fiber types. In: Sargeant AJ, Kernell D (eds.), Neuromuscular Fatigue, pp. 93-95. Amsterdam: Royal Netherlands Academy of Arts and Sciences.Google Scholar
  6. Beelen A, Sargeant AJ & Wijkhuizen F (1994). Measurement of directional force and power during human submaximal and maximal isokinetic exercise. European Journal of Applied Physiology 69, 1–5.CrossRefGoogle Scholar
  7. Bigland-Ritchie B & Woods JJ (1976). Integrated EMG and O2 uptake during positive and negative work. Journal of Physiology (London) 260, 267–277.Google Scholar
  8. Bottinelli R, Betto R, Schiaffino S & Reggiani C (1994). Unloaded shortening velocity and myosin heavy chain and alkali light chain isoform composition in rat skeletal muscle fibers. Journal of Physiology (London) 478, 3421–349.Google Scholar
  9. Bottinelli R, Schiaffino S & Reggiani C (1991). Force-velocity relations and myosin heavy chain isoform compositions of skinned fibers from rat skeletal muscle. Journal of Physiology (London) 437, 655–667.Google Scholar
  10. Buller AJ, Eccles JC & Eccles RM (1960). Interactions between motoneurones and muscles in respect of the characteristic speeds of their responses. Journal of Physiology (London) 150, 417–439.Google Scholar
  11. Burke RE, Levine DN, Tsairis P & Zajac, FE (1973). Physiological types and histochemical profiles in motor units of the cat gastrocnemius. Journal of Physiology (London) 234, 723–748.Google Scholar
  12. Cavagna GA, Dusman B & Margaria R (1968). Positive work done by a previously stretched muscle. Journal of Applied Physiology 24, 21–32.PubMedGoogle Scholar
  13. Curtin NA (1990). Force during stretch and shortening of frog sartorius muscle: effects of intracellular acidification due to increased carbon dioxide. Journal of Muscle Research and Cell Motility 11, 251–257.PubMedCrossRefGoogle Scholar
  14. de Haan A, Jones DA & Sargeant AJ (1989). Changes in power output, velocity of shortening and relaxation rate during fatigue of rat medial gastrocnemius muscle. Pflügers Archiv 413, 422–428.PubMedCrossRefGoogle Scholar
  15. de Haan A & Koudijs JCM (1994). A linear relationship between ATP degradation and fatigue during high-intensity dynamic exercise in rat skeletal muscle. Experimental Physiology 79, 865–868.PubMedGoogle Scholar
  16. de Haan A, Lodder MAN & Sargeant AJ (1991). Influence of an active pre-stretch on fatigue of skeletal muscle. European Journal of Applied Physiology 62, 268–273.CrossRefGoogle Scholar
  17. de Ruiter CJ, de Haan A & Sargeant AJ (1995). Physiological characteristics of two extreme muscle compartments in gastrocnemius medialis of the anaesthetized rat. Acta Physiologica Scandanavica 153, 313–324.CrossRefGoogle Scholar
  18. Ennion S, Sant’Ana Pereira JA, Sargeant AJ, Young A & Goldspink G (1995). Characterisation of human skeletal muscle fibers according to the myosin heavy chains they express. Journal of Muscle Research and Cell Motility 16, 35–43PubMedCrossRefGoogle Scholar
  19. Faulkner JA & Brooks SV (1993). Fatigability of mouse muscles during constant length, shortening, and lengthening contractions: interactions between fiber types and duty cycles. In: Sargeant AJ, Kernell D (eds.) Neuromuscular Fatigue, pp. 116-123. Amsterdam: Royal Netherlands Academy of Arts and Sciences.Google Scholar
  20. Faulkner JA, Jones DA, Round JM & Edwards RHT (1980). Dynamics of energetic processes in human muscle. In: Cerretelli P, Whipp BJ (eds.), Exercise Bioenergetics and Gas Exchange, pp. 81–90. Amsterdam: Elsevier/North-Holland Biomedical Press.Google Scholar
  21. Fitts RH, Costill DL & Gardetto PR (1989). Effect of swim training on human muscle fiber function. Journal of Applied Physiology 66, 465–475.PubMedGoogle Scholar
  22. Goldspink G (1978). Energy turnover during contraction of different types of muscle. In: Asmussen E, Jørgensen K (eds.), Biomechanics VI-A, pp. 27–39. Baltimore: University Park Press.Google Scholar
  23. Gollnick PD, Piehl K & Saltin B (1974). Selective glycogen depletion pattern in human muscle fibers after exercise of varying intensity and at varying pedaling rates. Journal of Physiology (London) 241, 45–57.Google Scholar
  24. Greig CA, Sargeant AJ & Vøllestad NK (1985). Muscle force and fiber recruitment during dynamic exercise in man. Journal of Physiology (London) 371, 176P.Google Scholar
  25. Herzog W & ter Keurs HEDJ (1988). Force-length relation of in-vivo human recrus femoris muscles. Pflügers Archiv. European Journal of Physiology 411, 642–647.PubMedCrossRefGoogle Scholar
  26. Hill AV (1950). The dimensions of animals and their muscular dynamics. Proceedings Royal Institute of Great Britain 34, 450–473.Google Scholar
  27. Hill AV (1956). The design of muscles. British Medical Bulletin 12, 165–166.PubMedGoogle Scholar
  28. Ivy JL, Chi M-Y, Hintz CS, Sherman WM, Hellendall RP & Lowry OH (1987). Progressive metabolic changes in individual human muscle fibers with increasing work rates. American Journal of Physiology 252, C630–C639.PubMedGoogle Scholar
  29. Jones DA & Bigland-Ritchie B (1986). Electrical and contractile changes in muscle fatigue. In Saltin B (ed.), Biochemistry of Exercise VI, pp. 337–392. Champaign, Ill: Human Kinetics Publishers.Google Scholar
  30. Kernell D (1983). Functional properties of spinal motoneurons and gradation of muscle force. In: Desmedt JE (ed.), Motor Control Mechanisms in Health and Disease, pp. 213–226. New York: Raven Press.Google Scholar
  31. Kernell D (1986). Organization and properties of spinal motoneurones and motor units. Progress in Brain Research 64, 21–30.PubMedCrossRefGoogle Scholar
  32. Kernell D (1992). Organized variability in the neuromuscular system: a survey of task-related adaptations. Archives Italiennes de Biologie 130, 19–66.PubMedGoogle Scholar
  33. Kernell D (1994). Motor tasks and functional organization of the neuromuscular system. Plenary lecture. Proceedings for Joint Meeting of the Dutch Physiological Society and The Physiological Society, 2P.Google Scholar
  34. Kernell D, Eerbeek O & Verhey BA (1983). Motor unit categorization on basis of contractile properties: an experimental analysis of the composition of the cat’s m. peroneus longus. Experimental Brain Research 50, 211–219.Google Scholar
  35. Komi PV (1984). Physiological and biomechanical correlates of muscle function. Effects of muscle structure and stretch shortening cycle on force and speed. In: Terjung R (ed.), Exercise and Sports Science Reviews, vol. 12, pp. 18–121. Lexington: Collamore Press.Google Scholar
  36. Kugelberg E (1973). Histochemical composition, contraction speed, and fatiguability of rat soleus motor units. Journal of Neurological Sciences 20, 177–198.CrossRefGoogle Scholar
  37. Kukulka CG & Clamann HP (1981). Comparison of the recruitment and discharge properties of motor units in human biceps brachii and adductor pollicis during isometric contractions. Brain Research 219, 45–55.PubMedCrossRefGoogle Scholar
  38. Larsson L & Moss RL (1993). Maximum velocity of shortening in relation to myosin isoform composition in single fibers from human skeletal muscles. Journal of Physiology (London) 472, 595–614.Google Scholar
  39. Lodder MAN, de Haan A & Sargeant AJ (1991). Effect of shortening velocity on work output and energy cost during repeated contractions of the rat EDL muscle. European Journal of Applied Physiology 62, 430–435.CrossRefGoogle Scholar
  40. Lowey S, Waller G S & Trybus KN (1993). Skeletal muscle myosin light chains are essential for physiological speed of shortening. Nature 365, 454–456.PubMedCrossRefGoogle Scholar
  41. McComas AJ, Galea V, Einhorn RW, Hicks AL & Kuiack S (1993). The role of the Na+, K+-pump in delaying muscle fatigue. In: Sargeant AJ, Kernell D (eds.), Neuromuscular Fatigue, pp. 35-43. Amsterdam: Royal Netherlands Academy of Arts and Sciences.Google Scholar
  42. Nardone A, Romnano C & Schieppati M (1989). Selective recruitment of high-threshold human motor units during voluntary isotonic lengthening of active muscles. Journal of Physiology (London) 409, 451–471.Google Scholar
  43. Pette D & Vrbová G (1992). Adaptation of mammalian skeletal muscle fibers to chronic electrical stimulation. Reviews in Physiology, Biochemistry and Pharmacology 120, 115–202.CrossRefGoogle Scholar
  44. Pierotti DJ, Roy RR, Bodine-Fowler SC, Hodgson JA & Edgerton VR (1991). Mechanical and morphological properties of chronically inactive cat tibialis anterior motor units. Journal of Physiology (London) 444, 175–192.Google Scholar
  45. Rome LC (1992). The design of the muscular system. In: Sargeant AJ, Kernell D (eds.), Neuromuscular Fatigue, pp. 129–136. Amsterdam: Royal Netherlands Academy of Arts and SciencesGoogle Scholar
  46. Rome LC, Sosnicki AA & Goble DO (1990). Maximum velocity of shortening of three fiber types from horse soleus muscle: implications for scaling with body size. Journal of Physiology (London) 431, 173–185.Google Scholar
  47. Rutherford OM & Jones DA (1988). Contractile properties and fatiguability of the human adductor pollicis and first dorsal interosseous: a comparison of the effects of two chronic stimulation patterns. Journal of Neurological Science 85, 319–331.CrossRefGoogle Scholar
  48. Salmons S & Vrbová G (1969). The influence of activity on some contractile characteristics of mammalian fast and slow muscles. Journal of Physiology (London) 201, 535–549.Google Scholar
  49. Saltin B & Rose RJ (eds.) (1994). The racing camel (Camelus dromedarius). Physiology, metabolic functions and adaptations. Acta Physiologica Scandinavica Supplement 617, 9–18.Google Scholar
  50. Sant’Ana Pereira JA, Wessels A, Nijtmans L, Moorman AFM & Sargeant AJ (1995). New method for the accurate characterisation of single human skeletal muscle fibers demonstrates a relation between mATPase and MyHC expression in pure and hybrid fibers types. Journal of Muscle Research and Cell Motility 16, 21–34.PubMedCrossRefGoogle Scholar
  51. Sargeant AJ (1987). Effect of muscle temperature on leg extension force and short-term power output in humans. European Journal of Applied Physiology 56, 693–698.CrossRefGoogle Scholar
  52. Sargeant AJ (1988). Optimum cycle frequencies in human movement. Journal of Physiology (London) 406, 49P.Google Scholar
  53. Sargeant AJ (1994a). ‘Acute’ and ‘chronic’ plasticity of human muscle and power output. Motor Control Symposium. Proceedings of the 2nd World Congress of Biomechanics. Stichting World Biomechanics, Nijmegen, The Netherlands, Volume II, 119.Google Scholar
  54. Sargeant AJ (1994b). Human power output and muscle fatigue. International Journal of Sports Medicine 15, 116–121.PubMedCrossRefGoogle Scholar
  55. Sargeant AJ & Beelen A (1993). Human muscle fatigue in dynamic exercise. In: Sargeant AJ, Kernell D (eds.), Neuromuscular Fatigue, pp. 81–92. Amsterdam: Royal Netherlands Academy of Arts and Sciences.Google Scholar
  56. Sargeant AJ, Hoinville E & Young A (1981). Maximum leg force and power output during short-term dynamic exercise. Journal of Applied Physiology 51, 1175–1182.PubMedGoogle Scholar
  57. Schantz PG & Dhoot GK (1987). Coexistence of slow and fast isoforms of contractile and regulatory proteins in human skeletal muscle fibers induced by endurance training. Acta Physiologica Scandinavica 131, 147–154.PubMedCrossRefGoogle Scholar
  58. Thomas CK, Johansson RS & Bigland-Ritchie B (1991). Attempts to physiologically classify human thenar motor units. Journal of Neurophysiology 65, 1501–1508.PubMedGoogle Scholar
  59. Unquez GA, Bodine-Fowler SC, Roy RR, Pierotti DJ & Edgerton VR (1993). Evidence of incomplete neural control of motor properties in cat anterior tibialis after self-reinnervation. Journal of Physiology (London) 472, 103–125.Google Scholar
  60. Vøllestad NK & Blom PCS (1985). Effect of varying exercise intensity on glycogen depletion in human muscle fibers. Acta Physiologica Scandinavica 125, 395–405.PubMedCrossRefGoogle Scholar
  61. Vøllestad NK, Vaage O & Hermansen L (1984). Muscle glycogen depletion patterns in type I and subgroups of type II fibers during prolonged severe exercise in man. Acta Physiologica Scandinavica 122, 433–441.PubMedCrossRefGoogle Scholar
  62. Woledge RC, Curtin NA & Homsher E (1985). Energetic aspects of muscle contraction. Monographs of the Physiological Society No. 41. London: Academic Press.Google Scholar
  63. Zoladz J, Rademacker A & Sargeant AJ (1995). Oxygen uptake does not increase linearly with power output at high intensities in humans. Journal of Physiology (London) In press.Google Scholar

Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • A. J. Sargeant
    • 1
  • D. A. Jones
    • 2
  1. 1.Department of Muscle and Exercise Physiology, Faculty of Human Movement SciencesVrije UniversityAmsterdamThe Netherlands
  2. 2.School of Sport and Exercise SciencesThe University of BirminghamEdgbaston, BirminghamUK

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