Abstract
Interleukin 3 (IL-3) and granulocyte-macrophage colony stimulating factor (GM-CSF) stimulate various lineage-committed cells as well as early multipotential progenitors while interleukin 5 (IL-5) stimulates eosinophils and basophils1. These three cytokines induce similar intracellular signals and exhibit similar functions in their common target cells. Although primary amino acid sequences of IL-3, IL-5 and GM-CSF show no obvious homology, they consist of four α-helices and their gross tertiary structures are similar. Interestingly, binding of a human cytokine to its high affinity receptor is inhibited by another cytokine on their common target cells, e.g. high affinity IL-3 binding to its receptor is inhibited by GM-CSF and vice versa2.
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© 1994 Springer Science+Business Media New York
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Mui, A. et al. (1994). Function of the Common β Subunit of the GM-CSF/IL-3/IL-5 Receptors. In: Gupta, S., Paul, W.E., DeFranco, A., Perlmutter, R.M. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation V. Advances in Experimental Medicine and Biology, vol 365. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0987-9_22
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DOI: https://doi.org/10.1007/978-1-4899-0987-9_22
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