Quantitative Aspects of Receptor Aggregation
The critical role aggregation plays in antibody-mediated activation of cellular responses is now familiar to immunologists. The experimental evidence that led to that understanding has been recounted on several occasions1,2 and the interpretation of the data has stood up well to the newer findings particularly as they relate to cell receptors. It is likewise well known that aggregation is also a widely used mechanism by systems outside those central to the immune response3. In this brief review we wish to focus on what progress has been made in extending our knowledge about some quantitative aspects of the aggregation mechanism.
KeywordsMast Cell Human Growth Hormone Antigen Receptor Receptor Aggregation FceRI Receptor
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