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Mechanisms of Lymphocyte Activation and Immune Regulation V pp 131–141Cite as

Involvement of Nonreceptor Protein Tyrosine Kinases in Multichain Immune Recognition Receptor Signal Transduction

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 365))

Abstract

The nonreceptor protein tyrosine kinases (PTKs) represent cellular enzymes grouped together based upon their lack of defined extracellular sequences. The currently identified nonreceptor PTKs can be divided into nine different enzyme groups based upon predicted structural features. With the exception of the Focal Adhesion Kinase (Fak) and the Activated Cdc42Hs-associated Kinase (Ack) which are the only known members of these two individual PTK groups, the remaining PTKs appear to be members of distinct PTK families. They range in size from about 50 kDa for the C-src Kinase (Csk) family to approximately 150 kDa for the Abl kinase family. All of these PTKs are likely to be involved in one or more signaling pathways that modulate growth, differentiation, and mature cell function.

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Author information

Authors and Affiliations

  1. Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey, 08543, USA

    Anne L. Burkhardt, Sandra J. Saouaf, Sandeep Mahajan & Joseph B. Bolen

Authors
  1. Anne L. Burkhardt
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  2. Sandra J. Saouaf
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  3. Sandeep Mahajan
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  4. Joseph B. Bolen
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Editor information

Editors and Affiliations

  1. Department of Medicine, University of California, Irvine, CA, 92717-4069, USA

    Sudhir Gupta

  2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892-0001, USA

    William E. Paul

  3. Department of Microbiology and Immunology, University of California, San Francisco, CA, 94143-0552, USA

    Anthony DeFranco

  4. Department of Immunology, University of Washington, Seattle, WA, 98915, USA

    Roger M. Perlmutter

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© 1994 Springer Science+Business Media New York

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Burkhardt, A.L., Saouaf, S.J., Mahajan, S., Bolen, J.B. (1994). Involvement of Nonreceptor Protein Tyrosine Kinases in Multichain Immune Recognition Receptor Signal Transduction. In: Gupta, S., Paul, W.E., DeFranco, A., Perlmutter, R.M. (eds) Mechanisms of Lymphocyte Activation and Immune Regulation V. Advances in Experimental Medicine and Biology, vol 365. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0987-9_14

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  • DOI: https://doi.org/10.1007/978-1-4899-0987-9_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4899-0989-3

  • Online ISBN: 978-1-4899-0987-9

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