Involvement of Nonreceptor Protein Tyrosine Kinases in Multichain Immune Recognition Receptor Signal Transduction
The nonreceptor protein tyrosine kinases (PTKs) represent cellular enzymes grouped together based upon their lack of defined extracellular sequences. The currently identified nonreceptor PTKs can be divided into nine different enzyme groups based upon predicted structural features. With the exception of the Focal Adhesion Kinase (Fak) and the Activated Cdc42Hs-associated Kinase (Ack) which are the only known members of these two individual PTK groups, the remaining PTKs appear to be members of distinct PTK families. They range in size from about 50 kDa for the C-src Kinase (Csk) family to approximately 150 kDa for the Abl kinase family. All of these PTKs are likely to be involved in one or more signaling pathways that modulate growth, differentiation, and mature cell function.
KeywordsFocal Adhesion Kinase Cytoplasmic Domain Cell Antigen Receptor Tyrosine Autophosphorylation Nonreceptor Protein Tyrosine Kinase
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