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Adrenocortical and Gonadal Steroids in Behavioral Cardiovascular Medicine

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Handbook of Research Methods in Cardiovascular Behavioral Medicine

Abstract

The purpose of this chapter is to provide guidelines for the evaluation of steroid hormone secretion as they relate to cardiovascular function. As aldosterone is covered elsewhere in a discussion of renin—angiotensin—aldosterone secretion (see Atlas, this volume), this chapter will focus on glucocorticoid and gonadal steroids. Parameters relevant to cardiovascular function are emphasized rather than classical endocrinologic methods for assessing adequacy of hormone secretion. This involves somewhat different strategies, as changes in hormone secretion rather than absolute hormone levels are of considerable importance, particularly in understanding the role of behavioral variables in cardiovascular disease.

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References

  • Abplanalp, J. M., Livingston, L., Rose, R., & Sanwisch, D. (1977). Cortisol and growth hormone responses to psychological stress during the menstrual cycle. Psychosomatic Medicine, 39, 158–177.

    PubMed  CAS  Google Scholar 

  • Abraham, G. E. (Ed.). (1974). Radioimmunoassay of steroids in biological fluids. Acta Endocrinologica Supplementum, 183.

    Google Scholar 

  • Adams, M. R., Kaplan, J. R., Clarkson, T. B., & Koritnik, D. R. (1984). Ovariectomy, social status and atherosclerosis in cynomolgus monkeys. Arteriosclerosis, 5, 192–200.

    Google Scholar 

  • Bjorkerud, S. (1974). Effect of adrenocortical hormones on the integrity of rat aortic endothelium. In Shettler, G., & Weizler, A. (Eds.), Atherosclerosis III (pp. 245–249). Berlin: Springer.

    Google Scholar 

  • Bondy, P. K., & Rosenberg, L. (1980). Metabolic control and disease (8th ed.). Philadelphia: Saunders.

    Google Scholar 

  • Chearskul, S., Rincon-Rodriguez, I., Sofi, S. B., Donaldson, A., & Jeffcoate, L. (1982). Simple, direct assays for the measurement of estradiol and progesterone in saliva, In Radioimmunoassay and related procedures in medicine (pp. 265–274). Vienna: IAEA.

    Google Scholar 

  • Christiansen, K., Knussmann, R., & Couwenbergs, C. (1985). Sex hormones and stress in the human male. Hormones and Behavior, 19, 426–440.

    Article  PubMed  CAS  Google Scholar 

  • Collins, A., Eneroth, P., & Landgren, B. M. (1985). Psychoneuroendocrine stress responses and mood as related to the menstrual cycle. Psychosomatic Medicine, 47, 512–527.

    PubMed  CAS  Google Scholar 

  • Estep, H. L., Island, D. P., Neu, R. L., & Liddle, G. W. (1968). Pituitary adrenal dynamics during surgical states. Journal of Clinical Endocrinology and Metabolism, 23, 419–425.

    Article  Google Scholar 

  • Ferguson, D. B. (1984). Physiological considerations in the use of salivary steroid estimation for clinical investigations. Frontiers of Oral Physiology, 5, 1–20.

    CAS  Google Scholar 

  • Frankenhaeuser, M. (1982). The sympathetic and pituitaryadrenal response to challenge: Comparison between the sexes. In T. Dembroski, T. H. Schmidt, & G. Blumchen (Eds.), Biobehavioral basis of coronary heart disease (pp. 91–106). Basel: Karger.

    Google Scholar 

  • Frederikson, M., Sundin, O., & Frankenhaeuser, M. (1985). Cortisol excretion during the defense reaction in humans. Psychosomatic Medicine, 47, 313–319.

    Google Scholar 

  • Friedman, M., George, S., Byers, S. O., & Rosenman, R. H. (1960). Excretion of catecholamines, 17-ketosteroids, 17-hydroxycorticoids and 5-hydroxyindole in men exhibiting a particular behavior pattern (A) associated with high incidence of clinical coronary artery disease. Journal of Clinical Investigation, 39, 758–764.

    Article  PubMed  CAS  Google Scholar 

  • Gray, G. D., Smith, E. R., Damassa, D. A., Ehrenkranz, J. R. L. & Davidson, J. M. (1978). Neuroendocrine mechanisms mediating the suppression of circulating testosterone levels associated with chronic stress in male rats. Neuroendocrinology, 25, 247–256.

    Article  PubMed  CAS  Google Scholar 

  • Griffin, J. E., & Wilson, J. D. (1980). The testis. In P. K. Bondy & L. E. Rosenberg (Eds.), Metabolic control and disease (pp. 1535–1620). Philadelphia: Saunders.

    Google Scholar 

  • Hartley, H. L., Mason, J. W., Hogan, R. P., Jones, L. G., Kotchen, T. A., Moughey, E. H., Wherry, F. E., Pennington, L. L., & Ricketts, P. T. (1972). Multiple hormonal responses to graded exercise in relation of physical training. Journal of Applied Physiology, 33, 602–606.

    PubMed  CAS  Google Scholar 

  • Hastrup, J. L., & Light, K. C. (1984). Sex differences in cardiovascular stress responses: Modulation as a function of menstrual cycle phases. Journal of Psychosomatic Research, 28, 475–483.

    Article  PubMed  CAS  Google Scholar 

  • Hazzard, W. R. (1984). The sex differential in longevity. In R. A. Andres & E. L. Bierman (Eds.), Principles of geriatric medicine (pp. 72–81). New York: McGraw-Hill.

    Google Scholar 

  • Hazzard, W. R. (1985). Atherogenesis: Why women live longer. Geriatrics, 40, 42–54.

    PubMed  CAS  Google Scholar 

  • Hellhammer, D. H., Hubert, W., & Schurmeyer, H. T. (1985). Changes in saliva testosterone after psychological stimulation in men. Psychoneuroendocrinology, 10, 77–81.

    Article  PubMed  CAS  Google Scholar 

  • Henry, J. P., Stephens, P. M., & Santisteban, G. A. (1975). A model of psychosocial hypertension showing reversibility and progression of cardiovascular complications. Circulation Research, 36, 156–164.

    Article  PubMed  CAS  Google Scholar 

  • Henry, J. P., Kross, M. E., Stephens, P. M., & Watson, F. M. C. (1976). Evidence that differing psychosocial stimuli lead to adrenal cortical stimulation by autonomic or endocrine pathways. In E. Usdin (Ed.), Catecholamines and stress (pp. 457–468). New York: Raven Press.

    Google Scholar 

  • Jeffcoate, S. L. (1975). Methods of hormone analysis. New York: Wiley.

    Google Scholar 

  • Kaplan, J. R., Manuck, S. B., Clarkson, T. B., Lusso, T. B., & Taub, D. M. (1982). Social status environment in atherosclerosis in cynomolgus monkeys. Arteriosclerosis, 2, 359–367.

    Article  PubMed  CAS  Google Scholar 

  • Kaplan, J. R., Adams, M. R., Clarkson, T. B., & Koritnik, D. R. (1984). Psychosocial influences on female protection among cynomolgus macaques. Atherosclerosis, 53, 283–295.

    Article  PubMed  CAS  Google Scholar 

  • Kawakami, M., Kubo, K., Uemura, T., Nagase, M., & Hayashi, R. (1981). Involvement of ovarian innervation in steroid secretion. Endocrinology, 109, 136–145.

    Article  PubMed  CAS  Google Scholar 

  • Klaibern, E. L., Broverman, D. M., Haffajee, C. I., Hochman, J. S., Sacks, G. M., & Dalen, J. E. (1982). Serum estradiol levels in men with acute myocardial infarction. American Journal of Medicine, 73, 872–881.

    Article  Google Scholar 

  • Knopp, R. H., Waiden, C. E., & Wahl, P. W. (1981). Oral contraceptive and postmenopausal estrogen effects on lipoprotein triglyceride and cholesterol in an adult female population: Relationships to estrogen and progestin potency. Journal of Clinical Endocrinology and Metabolism, 53, 1123–1132.

    Article  PubMed  CAS  Google Scholar 

  • Kreuz, M. A. J., Rose, R. M., & Jennings, J. R. (1972). Suppression of plasma testosterone levels and pyschological stress, Archives of General Psychology, 26, 479–482.

    Article  CAS  Google Scholar 

  • Landon, J., Smith, D. S., Perry, L. A., & Al-Ansari, A. A. K. (1984). The assay of salivary cortisol. In G. F. Read, D. Read-Fahmy, R. F. Walker, & K. Griffiths (Eds.), Immunoassays of steroids in saliva (pp. 301–307). London: Alpha Omega Publishing.

    Google Scholar 

  • Leshner, A. I. (1980). The interaction of experience and neuroendocrine factors in determining behavioral adaptations to aggression. Progress in Brain Research, 53, 427–438.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, J. G., & Elder, P. A. (1985). An enzyme-linked immunosorbent assay (ELISA) for plasma cortisol. Journal of Steroid Biochemistry, 22, 673–676.

    Article  PubMed  CAS  Google Scholar 

  • Luisi, M., Bernini, G. P., Del Genovese, A., Birindelli, R., Barletta, D., Gasperi, M., & Franchi, F. (1980). Radioimmunoassay for free testosterone in human saliva. Journal of Steroid Biochemistry, 12, 513–516.

    Article  PubMed  CAS  Google Scholar 

  • Luria, M. H., Johnson, M. W., Pego, R., Seuc, C. A., Manubens, S. J., Wieland, M. R., & Wieland, R. G. (1982). Relationship between sex hormones, myocardial infarction and occlusive coronary disease. Archives of Internal Medicine, 142, 42–44.

    Article  PubMed  CAS  Google Scholar 

  • Mason, J. W., Kenion, C. C., Collins, D. R., Mougey, E. H., Jones, J. A., Driver, G. C., Brady, J. V., & Beer, B. (1968). Urinary testosterone response to 72-hr avoidance session in the monkey. Psychosomatic Medicine, 30, 721–732.

    PubMed  Google Scholar 

  • Mason, J. W., Hartley, L. H., Kotchen, T. A., Moughey, E. H., Ricketts, P. T., & Jones, L. G. (1973). Plasma cortisol and norepinephrine responses in anticipation of muscular exercise. Psychosomatic Medicine, 35, 406–414.

    PubMed  CAS  Google Scholar 

  • Murphy, B. E. P. (1968). Clinical evaluation of urinary cortisol determinations by competitive protein binding. Journal of Endocrinology and Met. 28, 343–348.

    Article  CAS  Google Scholar 

  • Murphy, B. E. P., Engelberg, W., & Patter, C. J. (1963). Simple method for determination of plasma corticoids. Journal of Clinical Endocrinology and Metabolism, 23, 293–300.

    Article  PubMed  CAS  Google Scholar 

  • Nakashima, A., Koshiyama, K., Uozimi, T., Monden, Y., Hamanaka, Y., Kurachi, K., Aono, T., Mizutani, X., & Matsumoto, K. (1975). Effects of general anaesthesia and severity of surgical stress on serum LH and testosterone in males. Acta Endocrinologica, 78, 258–269.

    PubMed  CAS  Google Scholar 

  • Nieschlag, E., & Wickins, E. J. (1978). The role of testosterone in the evaluation of testicular function. In G. E. Abraham (Ed.), Radioassay systems in clinical endocrinology (pp. 169–196). New York: Dekker.

    Google Scholar 

  • Orth, D. N., Jackson, R. V., DeCherney, G. S., DeBold, C. R., Alexander, A. N., Island, D. P., Rivier, J., Rivier, C., Speiss, J., & Vale, W. (1983). Effects of ovine synthetic corticotropin releasing factor: Dose response of plasma adrenocorticotropin and cortisol. Journal of Clinical Investigation, 71, 587–595.

    Article  PubMed  CAS  Google Scholar 

  • Phillips, G. B., Castell, W. P., Abbott, R. D., & McNamara, P. M. (1983). Association of hyperestrogenemia and coronary heart disease in men in the Framingham cohort. American Journal of Medicine, 74, 863–869.

    Article  PubMed  CAS  Google Scholar 

  • Pinter, E. J., Peterfy, G., & Cleghorn, J. M. (1975). Studies in endocrine and affective functions in complex flight manoeuvres. Psychotherapy and Psychosomatics, 26, 93–100.

    Article  PubMed  CAS  Google Scholar 

  • Read-Fahmy, D., Read, G. F., & Walker, R. F. (1982). Steroids in saliva for assessing endocrine function. Endocrine Reviews, 3, 367–395.

    Article  Google Scholar 

  • Ritchie, J. C., Varroll, B. J., Olton, P. R., Shively, V., & Feinberg, M. (1985). Plasma cortisol determination for the dexamethasone suppression test. Archives of General Psychiatry, 42, 493–497.

    Article  PubMed  CAS  Google Scholar 

  • Rose, R. M., & Hurst, M. W. (1975). Plasma cortisol and growth hormone responses to intravenous catheterization. Journal of Human Stress, 1, 22–36.

    Article  PubMed  CAS  Google Scholar 

  • Rose, R. M., Gordon, T. P., & Bernstein, I. S. (1972). Plasma testosterone levels in the male rhesus monkey: Influence of sexual and social stimuli. Science, 178, 643–645.

    Article  PubMed  CAS  Google Scholar 

  • Rose, R. M., Jenkins, D., Hurst, M., Livingston, L., & Hasell, R. P. (1982). Endocrine activity in air traffic controllers at work. 1. Characterization of cortisol and growth hormone levels during the day. Psychoneuroendocrinology, 7, 101–111.

    Article  PubMed  CAS  Google Scholar 

  • Rosenfeld, S., Marmorston, J., Sobel, H., & White, A. E. (1960). Enhancement of experimental atherosclerosis by ACTH in the dog. Proceedings of the Society for Experimental Biology and Medicine, 103, 83–86.

    Article  PubMed  CAS  Google Scholar 

  • Schomig, A., Luth, B., Dietz, R., & Gross, F. (1976). Changes in vascular smooth muscle sensitivity to vasoconstrictor agents induced by corticosteroids, adrenalectomy, and differing salt intake in rats. Clinical Science and Molecular Medicine, 51, 51–63.

    Google Scholar 

  • Silber, R. H., & Porter, C. C. (1954). The determination of 17, 21-dihydroxy-20-ketosteroids in urine and plasma. Journal of Biological Chemistry, 210, 923–932.

    PubMed  CAS  Google Scholar 

  • Steger, R. W. (1982). Age dependent changes in the responsiveness of the reproductive system to pharmacologic agents. Pharmacology and Therapeutics, 17, 1–64.

    Article  PubMed  CAS  Google Scholar 

  • Streeten, D. H. P., Anderson, G. H., Dalakos, T. G., Seeley, D., Mallov, J. S., Eusebio, R., Sunderlin, F. S., Badawy, S. Z. A., & King, R. B. (1982). Normal and abnormal function of the hypothalamic-pituitary adrenocortical system in man. Endocrine Reviews, 5, 371–394.

    Article  Google Scholar 

  • Surwit, R. S., Allen, L. M., Gilgor, R. S., Schanberg, S., Kuhn, C., & Duvuc, M. (1982). Neuroendocrine response to cold in Raynaud’s syndrome. Life Sciences, 32, 995–1000.

    Article  Google Scholar 

  • Thorneycroft, I. H., Mishell, D. R., Stone, S. C., Kharma, K. M., & Nakamura, R. M. (1971). The relation of serum 17-hydroxyprogesterone and estradiol-17-beta levels during the human menstrual cycle. American Journal of Obstetrics and Gynecology, 111, 947–951.

    PubMed  CAS  Google Scholar 

  • Troxler, R. G., Sprague, E. A., Albanese, R. A., Fuchs, R., & Thompson, A. J. (1977). The association of elevated plasma cortisol and early atherosclerosis as demonstrated by coronary angiography. Atherosclerosis, 26, 151–162.

    Article  PubMed  CAS  Google Scholar 

  • Umeda, T., Hiramatsu, R., Iwaoka, T., Shimada, T. R., Miura, R., & Sato, T. (1981). Use of saliva for monitoring unbound free cortisol levels in serum. Clinica Chimica Acta, 110, 245–253.

    Article  CAS  Google Scholar 

  • Walker, R. F., Joyce, B. G., Dyas, J., & Read-Fahmy, D. (1984). Cortisol: Monitoring changes in normal adrenal activity. In G. F. Read, D. Read-Fahmy, R. F. Walker, & K. Griffiths (Eds.), Immunoassay of steroids in saliva (pp. 309–324). London: Alpha Omega Publishing.

    Google Scholar 

  • Weitzman, E. D., Fukushima, D., Nogeire, C., Roffwarg, H., Gallagher, T. F., & Hellman, L. (1971). 24 hour pattern of the episodic secretion of cortisol in normal subjects. Journal of Clinical Endocrinology and Metabolism, 33, 14–22.

    Article  PubMed  CAS  Google Scholar 

  • Williams, R. B., Lane, J. D., Kuhn, C. M., Melosh, W., White, A. D., & Schanberg, S. (1982). Type A behavior and elevated physiological and neuroendocrine responses to cognitive tasks. Science, 218, 483.

    Article  PubMed  Google Scholar 

  • Wilson, J. D., & Foster, D. W. (1980). Williams textbook of endocrinology. Philadelphia: Saunders.

    Google Scholar 

  • Yen, S. S. C., & Jaffe, R. B. (1986). Reproductive endocrinology. Philadelphia: Saunders.

    Google Scholar 

  • Zumoff, B., Fukushima, D. K., & Hellman, L. (1974). Intercomparison of four methods for measuring cortisol production. Journal of Clinical Endocrinology and Metabolism, 38, 169–180.

    Article  PubMed  CAS  Google Scholar 

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  1. Department of Pharmacology, Duke University Medical Center, Durham, North Carolina, 27710, USA

    Cynthia M. Kuhn

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  1. University of Miami, Coral Gables, Florida, USA

    Neil Schneiderman

  2. National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA

    Stephen M. Weiss  & Peter G. Kaufmann  & 

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Kuhn, C.M. (1989). Adrenocortical and Gonadal Steroids in Behavioral Cardiovascular Medicine. In: Schneiderman, N., Weiss, S.M., Kaufmann, P.G. (eds) Handbook of Research Methods in Cardiovascular Behavioral Medicine. The Springer Series in Behavioral Psychophysiology and Medicine. Springer, Boston, MA. https://doi.org/10.1007/978-1-4899-0906-0_12

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