Favorable Effect of Glycosaminoglycans on Cellular and Urinary Abnormalities in Idiopathic Calcium-Oxalate Nephrolithiasis
In our experience, idiopathic calcium-oxalate (CaOx) nephrolithiasis is generally associated with an increased oxalate self-exchange (SE) in red blood cells (RBC) (1). This anomaly seems to be related to an altered state of phosphorylation of the anion carrier (band-3 protein) (2). We also have evidence that some glycosaminoglycans (GAG) can inhibit band-3 phosphorylation and normalize oxalate SE (3). In view of these findings, and because of the possibility that the cellular transport defect could also be present in other cell lines, we have set up a clinical trial to check the effects of orally-administered GAG on lithogenic factors.
KeywordsCrystallization Heparin Oxalate Ghost Supersaturation
- 2.B Baggio, G Clari, G Marzaro, A Borsatti, and V Moret, IRCS Med. Sci. 14: 368 (1986).Google Scholar
- 3.B Baggio, G Clari, G Gambaro, F Marchini, E Marchi, R Mastacchi, and G Marzaro, in: “Inhibitors of Crystallization in Renal Lithiasis and their Clinical Application”, A Martelli, PF Buli, and B Marchesini, eds., Acta Medica, Roma (1987).Google Scholar